{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:58:51Z","timestamp":1793195931714,"version":"4.5.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["grants TRA\/2007\/5, HPF\/2010\/17, TRA\/2007\/5\/R and DIFA-2018-013"],"award-info":[{"award-number":["grants TRA\/2007\/5, HPF\/2010\/17, TRA\/2007\/5\/R and DIFA-2018-013"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated the predictive value of subset scales and full versions of the Hamilton Rating Scale for Depression (HAMD) for therapeutic outcomes in ECT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This secondary analysis of patients with major depression (N = 136; 63% female; age = 56.7 [SD = 14.8]) from the EFFECT-Dep trial (NCT01907217) examined the predictive value of Evans-6, Toronto-7, Gibbons-8 and Maier-Philip 6 HAMD subset scales and three \u2018full\u2019 versions (HAMD-17, HAMD-21 and HAMD-24) on therapeutic outcomes. We also examined early improvement on subset scales and full versions as predictors of response and remission and explored predictive abilities of individual HAMD-24 items.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The subset scales and full scales lacked sufficient predictive ability for response and remission. Receiver operating characteristic curves identified a lack of discriminative capacity of HAMD subset scales and full versions at baseline to predict response and remission. Only the Maier-Philip-6 was significantly associated with percentage reduction in HAMD-24 scores from baseline to end of ECT course. Early improvement on most of the subset scales and full versions was a sensitive and specific predictor of response and remission. Four of the HAMD-24 items were significantly associated with response and one with remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Limited utility of the HAMD subset scales and full versions in this context highlight a need for more tailored depression rating scales for ECT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0259861","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T13:48:46Z","timestamp":1636465726000},"page":"e0259861","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6317-4428","authenticated-orcid":true,"given":"Caoimhe","family":"Fenton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-2799","authenticated-orcid":true,"given":"Declan M.","family":"McLoughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"issue":"9360","key":"pone.0259861.ref001","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0140-6736(03)12705-5","article-title":"Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis.","volume":"361","author":"UK ECT Review Group","year":"2003","journal-title":"Lancet"},{"issue":"3","key":"pone.0259861.ref002","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1017\/S0033291716002737","article-title":"Bitemporal v. high-dose right unilateral electroconvulsive therapy for depression: a systematic review and meta-analysis of randomized controlled trials.","volume":"47","author":"E Kolshus","year":"2017","journal-title":"Psychological Medicine."},{"issue":"2","key":"pone.0259861.ref003","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1192\/bjp.2017.28","article-title":"Prediction of electroconvulsive therapy response and remission in major depression: meta-analysis.","volume":"212","author":"L van Diermen","year":"2018","journal-title":"Br J Psychiatry"},{"issue":"1","key":"pone.0259861.ref004","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"M Hamilton","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"pone.0259861.ref005","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00406-011-0263-x","article-title":"Sensitivity to changes during antidepressant treatment: a comparison of unidimensional subset scales of the Inventory of Depressive Symptomatology (IDS-C) and the Hamilton Depression Rating Scale (HAMD) in patients with mild major, minor or subsyndromal depression.","volume":"262","author":"I Helmreich","year":"2012","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"6","key":"pone.0259861.ref006","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0022-3956(02)00024-9","article-title":"A critical examination of the sensitivity of unidimensional subscales derived from the Hamilton Depression Rating Scale to antidepressant drug effects","volume":"36","author":"R Entsuah","year":"2002","journal-title":"J Psychiatr Res"},{"issue":"12","key":"pone.0259861.ref007","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1176\/appi.ajp.161.12.2163","article-title":"The Hamilton Depression Rating Scale: has the gold standard become a lead weight?","volume":"161","author":"RM Bagby","year":"2004","journal-title":"Am J Psychiatry."},{"issue":"3","key":"pone.0259861.ref008","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1600-0447.1981.tb00676.x","article-title":"The Hamilton depression scale. Evaluation of objectivity using logistic models.","volume":"63","author":"P Bech","year":"1981","journal-title":"Acta Psychiatr Scand"},{"issue":"3","key":"pone.0259861.ref009","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jpsychires.2003.11.003","article-title":"An Item Response analysis of the Hamilton Depression Rating Scale using shared data from two pharmaceutical companies","volume":"38","author":"KR Evans","year":"2004","journal-title":"J Psychiatr Res"},{"issue":"11","key":"pone.0259861.ref010","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1503\/cmaj.050786","article-title":"Measuring the severity of depression and remission in primary care: validation of the HAMD-7 scale.","volume":"173","author":"RS McIntyre","year":"2005","journal-title":"Cmaj"},{"issue":"3","key":"pone.0259861.ref011","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0022-3956(93)90037-3","article-title":"Exactly what does the Hamilton Depression Rating Scale 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