{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:31:22Z","timestamp":1785267082364,"version":"3.55.0"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2019JJ50710"],"award-info":[{"award-number":["2019JJ50710"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"crossref","award":["2017YFD0500506"],"award-info":[{"award-number":["2017YFD0500506"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chinese Academy of Agricultural Science","award":["ASTIP-IBFC"],"award-info":[{"award-number":["ASTIP-IBFC"]}]},{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture and Rural Affairs","doi-asserted-by":"crossref","award":["CARS-42"],"award-info":[{"award-number":["CARS-42"]}],"id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Magnolol is a bioactive polyphenolic compound commonly found in<jats:italic>Magnolia officinalis<\/jats:italic>. The aim of this study is to clarify the contribution of the magnolol additive on the growth performance of<jats:italic>Linwu<\/jats:italic>ducklings aging from 7 to 28 d, comparing to the effects of antibiotic additive (colistin sulphate). A total of 325, 7-d-old ducklings were assigned to 5 groups. Each group had 5 cages with 13 ducklings in each cage. The ducklings in different groups were fed with diets supplemented with 0, 100, 200 and 300 mg\/kg magnolol additive (MA) (Control, MA100, MA200 and MA300) and 30 mg\/kg colistin sulphate (CS30) for 3 weeks, respectively. Parameters regarding to the growth performance, intestinal mucosal morphology, serum biochemical indices, antioxidant and peroxide biomarkers and the expression levels of antioxidant-related genes were evaluated by one way ANOVA analysis. The results showed that 30 mg\/kg colistin sulphate, 200 and 300 mg\/kg magnolol additive improved the average final weight (<jats:italic>P<\/jats:italic>= 0.045), average daily body weight gain (<jats:italic>P<\/jats:italic>= 0.038) and feed\/gain ratios (<jats:italic>P<\/jats:italic>= 0.001) compared to the control group. 200 and 300 mg\/kg magnolol additive significantly increased the villus height\/crypt depth ratio of ileum, compared to the control and CS30 groups (<jats:italic>P<\/jats:italic>= 0.001). Increased serum level of glucose (<jats:italic>P<\/jats:italic>= 0.011) and total protein (<jats:italic>P<\/jats:italic>= 0.006) were found in MA200 or MA300 group. In addition, comparing to the control and CS30 groups, MA200 or MA300 significantly increased the levels of superoxide dismutase (<jats:italic>P<\/jats:italic>= 0.038), glutathione peroxidase (<jats:italic>P<\/jats:italic>= 0.048) and reduced glutathione (<jats:italic>P<\/jats:italic>= 0.039) in serum. Moreover, the serum and hepatic levels of 8-hydroxy-2\u2019-deoxyguanosine (<jats:italic>P<\/jats:italic>= 0.043 and 0.007, respectively) were lower in all MA groups compared to those of the control and CS30 group. The hepatic mRNA expression levels of<jats:italic>superoxide dismutase-1<\/jats:italic>,<jats:italic>catalase<\/jats:italic>and<jats:italic>nuclear factor erythroid-2-related factor 2\/erythroid-derived CNC-homology factor<\/jats:italic>were also increased significantly in MA200 and MA300 groups (<jats:italic>P<\/jats:italic>&lt; 0.05). Taken together, these data demonstrated that MA was an effective feed additive enhancing the growth performance of<jats:italic>Linwu<\/jats:italic>ducklings at 7 to 28 d by improving the antioxidant and intestinal mucosal status. It suggested that MA could be a potential ingredient to replace the colistin sulphate in diets.<\/jats:p>","DOI":"10.1371\/journal.pone.0259896","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T18:26:52Z","timestamp":1640975212000},"page":"e0259896","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Magnolol additive improves growth performance of Linwu ducklings by modulating antioxidative status"],"prefix":"10.1371","volume":"16","author":[{"given":"Qian","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6579-3633","authenticated-orcid":true,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuo","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajiao","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuzhong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"issue":"5","key":"pone.0259896.ref001","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.2527\/jas.2014-8739","article-title":"Heat stress impairs mitochondria functions and induces oxidative injury in broiler chickens","volume":"93","author":"C Huang","year":"2015","journal-title":"Journal of Animal Science"},{"issue":"4","key":"pone.0259896.ref002","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1095-6433(02)00011-9","article-title":"obligatory thermogenesis in young birds: a cautionary note","volume":"131","author":"Hohtola E. 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