{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:28:58Z","timestamp":1788557338948,"version":"build-2803163510"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Carpal tunnel syndrome (CTS) is the most common compressive neuropathy. Patients who have unilateral symptoms are frequently found to have bilateral CTS by electrodiagnostic (EDx) study. We aimed to (a) study the prevalence and identify the predictive factors for bilateral CTS diagnosed by EDx; and (b) develop a model to predict bilateral CTS.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The retrospective clinical and EDx data of patients with CTS were collected and analyzed using the Chi-squared test and multiple logistic regression analysis. A model was fitted, and the best cutoff point determined. Calibration and discrimination performance of the model were performed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 327 patients with a mean age of 50.0 years were enrolled. Most were women (82.6%), and the most common presenting symptom was hand numbness (93.6%). The median duration of symptoms was 60 days. The prevalence of bilateral CTS was 80.7%. In the multivariate analysis, the predictive factors for bilateral CTS were the presence of bilateral symptoms (AOR 6.7 [95%CI 3.1\u201314.3]), thenar muscle weakness (AOR 3.9 [95%CI 1.3\u201311.6]), and age \u2265 45 years (AOR 2.5 [95%CI 1.3\u20134.6]). The logistic regression model was fitted, and the best cutoff point determined. The area under the receiver operating curve (AUC) was 0.76. The respective optimism-corrected C index and Somers\u2019 D was 0.762 and 0.524.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The prevalence of bilateral CTS was 80.7%. Our findings suggest bilateral CTS was predicted with adequate diagnostic accuracy by bilateral symptoms, age \u2265 45 years, and thenar muscle weakness.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0260578","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T18:36:37Z","timestamp":1640284597000},"page":"e0260578","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence and predictive factors for bilateral carpal tunnel syndrome by electrodiagnosis: A retrospective study"],"prefix":"10.1371","volume":"16","author":[{"given":"Apiradee","family":"Singjam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchana","family":"Charoentanyarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6985-9735","authenticated-orcid":true,"given":"Jittima","family":"Saengsuwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"issue":"4","key":"pone.0260578.ref001","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/mus.22208","article-title":"ELECTRODIAGNOSTIC EVALUATION OF CARPAL TUNNEL SYNDROME","volume":"44","author":"RA Werner","year":"2011","journal-title":"Muscle & Nerve"},{"key":"pone.0260578.ref002","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.pmr.2007.07.008","article-title":"Electrodiagnosis of Carpal Tunnel Syndrome","volume":"18","author":"LR Robinson","year":"2007","journal-title":"Phys Med Rehabil Clin N Am"},{"issue":"2A","key":"pone.0260578.ref003","first-page":"202","article-title":"Carpal tunnel syndrome: clinical and epidemiological study in 668 cases","volume":"57","author":"JA Kouyoumdjian","year":"1999","journal-title":"Arq Neuropsiquiatr"},{"issue":"4","key":"pone.0260578.ref004","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5350\/BTDMJB201511405","article-title":"Evaluation of 45 patients with Carpal tunnel syndrome","volume":"11","author":"M Bicer","year":"2015","journal-title":"Medical Journal of Bakirkoy"},{"issue":"8","key":"pone.0260578.ref005","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/milmed\/167.8.647","article-title":"An evaluation of provocative testing in the diagnosis of carpal tunnel syndrome","volume":"167","author":"C Walters","year":"2002","journal-title":"Mil Med"},{"issue":"5","key":"pone.0260578.ref006","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/01.PHM.0000124439.14757.99","article-title":"Clinical utility of the flick maneuver in diagnosing carpal tunnel syndrome","volume":"83","author":"PA Hansen","year":"2004","journal-title":"American Journal of Physical Medicine & Rehabilitation"},{"issue":"4","key":"pone.0260578.ref007","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jbspin.2007.09.014","article-title":"Clinical diagnosis of carpal tunnel syndrome: old tests-new concepts","volume":"75","author":"Y El Miedany","year":"2008","journal-title":"Joint Bone Spine"},{"issue":"1","key":"pone.0260578.ref008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajim.20915","article-title":"Physical examination has a low yield in screening for carpal tunnel syndrome","volume":"54","author":"AM Dale","year":"2011","journal-title":"Am J Ind Med"},{"key":"pone.0260578.ref009","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cnp.2018.02.005","article-title":"Nerve conduction studies and EMG in carpal tunnel syndrome: Do they add value?","volume":"3","author":"M Sonoo","year":"2018","journal-title":"Clin Neurophysiol Pract"},{"issue":"5","key":"pone.0260578.ref010","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0266-7681(98)80010-7","article-title":"Incidence of bilateral symptoms in carpal tunnel syndrome","volume":"23","author":"L Padua","year":"1998","journal-title":"J Hand Surg Br"},{"issue":"5","key":"pone.0260578.ref011","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1302\/0301-620X.83B5.0830655","article-title":"The carpel tunnel syndrome is a bilateral disorder","volume":"83B","author":"AE Bagatur","year":"2001","journal-title":"Journal of Bone and Joint Surgery-British Volume"},{"issue":"10","key":"pone.0260578.ref012","first-page":"1252","article-title":"Electrophysiological severity of carpal tunnel syndrome according to age in adult patients","volume":"145","author":"P Vicuna","year":"2017","journal-title":"Revista Medica De Chile"},{"issue":"2","key":"pone.0260578.ref013","doi-asserted-by":"crossref","first-page":"151","DOI":"10.13075\/ijomeh.1896.01517","article-title":"The bilaterality of idiopathic carpal tunnel syndrome among manual workers","volume":"33","author":"M. 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