{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:16:26Z","timestamp":1747196186970,"version":"3.40.5"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program through the National research Foundation of Korea","award":["NRF-2020R1I1A1A01072972"],"award-info":[{"award-number":["NRF-2020R1I1A1A01072972"]}]},{"name":"Bio and Medical Technology Development Program of the NRF","award":["NRF- 2020M3A9E8024875"],"award-info":[{"award-number":["NRF- 2020M3A9E8024875"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>Immune responses for cancer cells can be altered according to genetic variation of human leukocyte antigen (HLA). Association of HLA polymorphism with risk of various cancer types is well known. However, the association between HLA and glioblastoma (GBM) remains uncertain. We sought to evaluate the association of HLA polymorphism with risk of GBM development in Koreans.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>A case-control study was performed to identify the odds ratios (OR) of HLA class I and II genes for GBM. The control group consisted of 142 healthy Korean volunteers, and the GBM group was 80 patients with newly diagnosed GBM at our institution. HLA class I (-A, -B, and\u2013C) and class II (-DR, -DQ, and\u2013DP) genotyping was performed by high-resolution polymerase chain reaction (PCR)-sequence-based typing (PCR-SBT) methods.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>There were significantly decreased frequencies of HLA-A*26:02 (OR 0.22 CI 0.05\u20130.98), HLA-C*08:01 (OR 0.29 CI 0.10\u20130.87), and HLA-DRB1*08:03 (OR 0.32 CI 0.11\u20130.98), while there was significantly increased frequency of HLA-C*04:01 (OR 2.29 CI 1.05\u20134.97). In analysis of haplotypes, the frequency of DRB1*14:05-DQB1*05:03 was significantly decreased (OR 0.22 CI 0.05\u20130.98).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study suggests that genetic variations of HLA may affect GBM development in Koreans. Further investigations with larger sample sizes are needed to delineate any potential role of the HLA polymorphisms in the pathogenesis of GBM development.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0260618","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T18:52:24Z","timestamp":1639075944000},"page":"e0260618","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["HLA polymorphisms and risk of glioblastoma in Koreans"],"prefix":"10.1371","volume":"16","author":[{"given":"Sang-Soo","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haeyoun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3630-3364","authenticated-orcid":true,"given":"In-Cheol","family":"Baek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon A.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9827-9913","authenticated-orcid":true,"given":"Jae-Sung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai-Gyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sin-Soo","family":"Jeun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-1597","authenticated-orcid":true,"given":"Stephen","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"issue":"5","key":"pone.0260618.ref001","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"R Stupp","year":"2009","journal-title":"The lancet oncology"},{"issue":"10","key":"pone.0260618.ref002","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"R Stupp","year":"2005","journal-title":"New England journal of medicine"},{"issue":"11","key":"pone.0260618.ref003","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/neuonc\/noz123","article-title":"Risk factors for childhood and adult primary brain tumors","volume":"21","author":"QT Ostrom","year":"2019","journal-title":"Neuro-oncology"},{"issue":"7","key":"pone.0260618.ref004","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/neuonc\/nou087","article-title":"The epidemiology of glioma in adults: a \u201cstate of the science\u201d review","volume":"16","author":"QT Ostrom","year":"2014","journal-title":"Neuro-oncology"},{"issue":"4","key":"pone.0260618.ref005","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/ijc.10239","article-title":"History of allergies among adults with glioma and controls","volume":"98","author":"JL Wiemels","year":"2002","journal-title":"International journal of cancer"},{"issue":"2","key":"pone.0260618.ref006","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11060-018-2816-6","article-title":"Allergic conditions and risk of glioma and meningioma in the CERENAT case-control study","volume":"138","author":"C Pouchieu","year":"2018","journal-title":"Journal of Neuro-Oncology"},{"issue":"1","key":"pone.0260618.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-018-1027-5","article-title":"Impact of atopy on risk of glioma: a Mendelian randomisation study","volume":"16","author":"L Disney-Hogg","year":"2018","journal-title":"BMC medicine"},{"issue":"5258","key":"pone.0260618.ref008","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1126\/science.272.5258.67","article-title":"Population biology of antigen presentation by MHC class I molecules","volume":"272","author":"P Parham","year":"1996","journal-title":"Science"},{"issue":"5","key":"pone.0260618.ref009","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nri.2017.143","article-title":"HLA variation and disease","volume":"18","author":"CA Dendrou","year":"2018","journal-title":"Nature Reviews Immunology"},{"key":"pone.0260618.ref010","first-page":"597","article-title":"De O. 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