{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:54:01Z","timestamp":1787169241687,"version":"build-2736575974"},"reference-count":123,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Anadolu University Scientific Research Project Commission","award":["1704S097"],"award-info":[{"award-number":["1704S097"]}]},{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"crossref","award":["117S826"],"award-info":[{"award-number":["117S826"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    <jats:italic>Chlamydia pneumoniae (Cpn)<\/jats:italic>\n                    is a gram-negative intracellular pathogen that causes a variety of pulmonary diseases, and there is growing evidence that it may play a role in Alzheimer\u2019s disease (AD) pathogenesis. Cpn can interact functionally with host histones, altering the host\u2019s epigenetic regulatory system by introducing bacterial products into the host tissue and inducing a persistent inflammatory response. Because Cpn is difficult to propagate, isolate, and detect, a modified LPS-like neuroinflammation model was established using lyophilized cell free supernatant (CFS) obtained from infected cell cultures, and the effects of CFS were compared to LPS. The neuroprotective effects of Trichostatin A (TSA), givinostat, and RG108, which are effective on epigenetic mechanisms, and the antibiotic rifampin, were studied in this newly introduced model and in the presence of amyloid beta (A\u03b2) 1\u201342. The neuroprotective effects of the drugs, as well as the effects of CFS and LPS, were evaluated in A\u03b2-induced neurotoxicity using a real-time cell analysis system, total ROS, and apoptotic impact. TSA, RG108, givinostat, and rifampin all demonstrated neuroprotective effects in both this novel model and A\u03b2-induced neurotoxicity. The findings are expected to provide early evidence on neuroprotective actions against Cpn-induced neuroinflammation and A\u03b2-induced neurotoxicity, which could represent a new treatment option for AD, for which there are currently few treatment options.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0260633","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T16:09:08Z","timestamp":1638288548000},"page":"e0260633","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neuroprotective effects of some epigenetic modifying drugs\u2019 on Chlamydia pneumoniae-induced neuroinflammation: A novel 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