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Women in the Bogalusa Heart Study (n = 1401) had been linked to birth certificates for birthweight and gestational data, which were examined relative to childhood (ages 4\u201316) cardiometabolic indicators, indicated by mean levels overall and total risk factor burden as estimated by area under the curve (AUC) computed from longitudinal quadratic random-effects growth models. Women reported the birthweight and gestational age of each of their own pregnancies, and delivery medical records were linked to interview data where possible. Path analyses were conducted to examine the relationships among a woman\u2019s own birth outcomes, childhood and preconception adult cardiovascular health, and birth outcomes. Mean blood pressure (systolic blood pressure (SBP) adjusted relative risk (aRR) per 1-SD increase, 1.27, 95% CI 1.04\u20131.57) and low-density lipoprotein (aRR 1.21, 95% CI 1.02\u20131.44) in childhood predicted preterm birth (PTB), while mean SBP (aRR 1.33, 95% CI 1.02\u20131.74) predicted term low birthweight. The AUC data suggested an association between blood pressure and PTB (aRR for SBP top 10%, 1.86, 95% CI 1.08\u20133.21). Pre-pregnancy total cholesterol was negatively associated with gestational age. In path analyses, positive associations were found for each step between own birthweight, childhood BMI, pre-pregnancy BMI, and child\u2019s birthweight. Childhood levels of some, though not all, cardiovascular risk factors may predict adverse birth outcomes (preterm birth and reduced fetal growth).<\/jats:p>","DOI":"10.1371\/journal.pone.0260703","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T18:29:37Z","timestamp":1643221777000},"page":"e0260703","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lifetime cardiovascular risk factors and maternal and offspring birth outcomes: Bogalusa Babies"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-0922","authenticated-orcid":true,"given":"Emily W.","family":"Harville","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maeve E.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia A.","family":"Bazzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"issue":"10","key":"pone.0260703.ref001","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1097\/HJH.0b013e32833cd31f","article-title":"Amplification of the association between birthweight and blood pressure with age: the Bogalusa Heart Study","volume":"28","author":"W Chen","year":"2010","journal-title":"J Hypertens"},{"key":"pone.0260703.ref002","first-page":"176","article-title":"Low birth weight is associated with higher blood pressure variability from childhood to young adulthood: the Bogalusa Heart Study","volume":"7","author":"W Chen","year":"2012","journal-title":"Am J Epidemiol"},{"issue":"9","key":"pone.0260703.ref003","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/jech.2008.084475","article-title":"The association of birth weight with arterial stiffness at mid-adulthood: the Bogalusa Heart Study","volume":"63","author":"F Mzayek","year":"2009","journal-title":"J Epidemiol Community Health"},{"issue":"6","key":"pone.0260703.ref004","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1089\/met.2012.0031","article-title":"Is the metabolic syndrome a \"small baby\" syndrome?: the bogalusa heart study","volume":"10","author":"EW Harville","year":"2012","journal-title":"Metab Syndr Relat Disord"},{"issue":"6","key":"pone.0260703.ref005","doi-asserted-by":"crossref","first-page":"610 e1","DOI":"10.1016\/j.ajog.2007.04.024","article-title":"Early pregnancy lipid concentrations and spontaneous preterm birth","volume":"197","author":"JM Catov","year":"2007","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"pone.0260703.ref006","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/aje\/kwm273","article-title":"Inflammation and dyslipidemia related to risk of spontaneous preterm birth","volume":"166","author":"JM Catov","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"7","key":"pone.0260703.ref007","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/aje\/kwp211","article-title":"Metabolic syndrome in early pregnancy and risk of preterm birth","volume":"170","author":"L Chatzi","year":"2009","journal-title":"Am J Epidemiol"},{"issue":"6","key":"pone.0260703.ref008","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/jp.2017.22","article-title":"Maternal serum markers of lipid metabolism in relation to neonatal anthropometry","volume":"37","author":"NS Boghossian","year":"2017","journal-title":"J Perinatol"},{"issue":"4","key":"pone.0260703.ref009","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ajog.2007.07.015","article-title":"A population study of the contribution of medical comorbidity to the risk of prematurity in blacks","volume":"197","author":"DB Ehrenthal","year":"2007","journal-title":"Am J Obstet Gynecol"},{"issue":"Suppl D","key":"pone.0260703.ref010","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1016\/j.clinthera.2007.12.015","article-title":"Achieving better outcomes in pregnancies complicated by type 1 and type 2 diabetes mellitus","volume":"29","author":"B. 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