{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:01:35Z","timestamp":1787022095793,"version":"build-2736575974"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1091302"],"award-info":[{"award-number":["APP1091302"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1102905"],"award-info":[{"award-number":["APP1102905"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Movement adapts during acute pain. This is assumed to reduce nociceptive input, but the interpretation may not be straightforward. We investigated whether movement adaptation during pain reflects a purposeful search for a less painful solution. Three groups of participants performed two blocks (Baseline, Experimental) of wrist movements in the radial-ulnar direction. For the Control group (n = 10) both blocks were painfree. In two groups, painful electrical stimulation was applied at the elbow in Experimental conditions when the wrist crossed radial-ulnar neutral. Different stimulus intensities were given for specific wrist angles in a secondary direction (flexion-extension) as the wrist passed radial-ulnar neutral (\n                    <jats:italic>Pain 5\u20131 group<\/jats:italic>\n                    :painful stimulation at ~5 or ~1\/10\u2014n = 21;\n                    <jats:italic>Pain 5\u20130 group<\/jats:italic>\n                    :~5 or 0(no stimulation)\/10\u2014n = 6)). Participants were not informed about the less painful alternative and could use any strategy. We recorded the percentage of movements using the wrist flexion\/extension alignment that evoked the lower intensity noxious stimulus, movement variability, and change in wrist\/forearm alignment during pain. Participants adapted their strategy of wrist movement during pain provocation and reported less pain over time. Three adaptations of wrist movement were observed; (i) greater use of the wrist alignment with no\/less noxious input (Pain 5\u20131, n = 8\/21; Pain 5\u20130, n = 2\/6); (ii) small (n = 9\/21; n = 3\/6) or (iii) large (n = 4\/21; n = 1\/6) change of wrist\/forearm alignment to a region that was not allocated to provide an actual reduction in noxious stimulus. Pain reduction was achieved with \u201ctaking action\u201d to relieve pain and did not depend on reduced noxious stimulus.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0260715","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T13:36:19Z","timestamp":1638970579000},"page":"e0260715","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["\u201cTaking action\u201d to reduce pain\u2014Has interpretation of the motor adaptation to pain been too simplistic?"],"prefix":"10.1371","volume":"16","author":[{"given":"Michael","family":"Bergin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill","family":"Vicenzino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-9107","authenticated-orcid":true,"given":"Paul W.","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"issue":"3 Suppl","key":"pone.0260715.ref001","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1016\/j.pain.2010.10.020","article-title":"Moving differently in pain: a new theory to explain the adaptation to pain","volume":"152","author":"PW Hodges","year":"2011","journal-title":"Pain"},{"issue":"5","key":"pone.0260715.ref002","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1139\/y91-102","article-title":"The pain-adaptation model: a discussion of the relationship between chronic musculoskeletal pain and motor activity","volume":"69","author":"JP Lund","year":"1991","journal-title":"Can J Physiol Pharmacol"},{"issue":"4","key":"pone.0260715.ref003","first-page":"263","article-title":"Orofacial pain and jaw muscle activity: a new model","volume":"21","author":"GM Murray","year":"2007","journal-title":"J Orofac Pain"},{"key":"pone.0260715.ref004","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0268-0033(86)90085-9","article-title":"A critical review of the evidence for a pain-spasm-pain cycle in spinal disorders","volume":"1","author":"M. Roland","year":"1986","journal-title":"Clin Biomech"},{"issue":"1","key":"pone.0260715.ref005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(93)90183-P","article-title":"Afferent and spinal mechanisms of joint pain","volume":"55","author":"HG Schaible","year":"1993","journal-title":"Pain"},{"key":"pone.0260715.ref006","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0304-3959(95)00133-6","article-title":"Sensory-motor interactions of human experimental unilateral jaw muscle pain: a quantitative analysis","volume":"64","author":"P Svensson","year":"1995","journal-title":"Pain"},{"issue":"11","key":"pone.0260715.ref007","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1152\/jn.00911.2013","article-title":"Task dependency of motor adaptations to an acute noxious stimulation","volume":"111","author":"F Hug","year":"2014","journal-title":"J Neurophysiol"},{"issue":"6","key":"pone.0260715.ref008","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.jelekin.2013.08.014","article-title":"Effect of pain location on spatial reorganisation of muscle activity","volume":"23","author":"F Hug","year":"2013","journal-title":"J Electromyogr Kinesiol"},{"issue":"9","key":"pone.0260715.ref009","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.ejpain.2010.03.006","article-title":"Changes in motor unit recruitment strategy during pain alters force direction","volume":"14","author":"KJ Tucker","year":"2010","journal-title":"Eur J Pain"},{"issue":"2","key":"pone.0260715.ref010","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00421-013-2777-6","article-title":"Does movement variability increase or decrease when a simple wrist task is performed during acute wrist extensor muscle pain?","volume":"114","author":"MJ Bergin","year":"2014","journal-title":"Eur J Appl Physiol"},{"issue":"4","key":"pone.0260715.ref011","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00221-007-1199-2","article-title":"Changes in the degree of motor variability associated with experimental and chronic neck-shoulder pain during a standardised repetitive arm movement","volume":"185","author":"P Madeleine","year":"2008","journal-title":"Exp Brain Res"},{"issue":"2","key":"pone.0260715.ref012","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1037\/0735-7044.120.2.474","article-title":"Reduced variability of postural strategy prevents normalisation of motor changes induced by back pain\u2014a risk factor for chronic trouble?","volume":"120","author":"GL Moseley","year":"2006","journal-title":"Behav Neurosci"},{"issue":"2","key":"pone.0260715.ref013","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.brainresrev.2004.07.005","article-title":"The organization of motor responses to noxious stimuli","volume":"46","author":"RW Clarke","year":"2004","journal-title":"Brain Res Brain Res Rev"},{"issue":"3","key":"pone.0260715.ref014","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0304-3959(99)00242-0","article-title":"Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art","volume":"85","author":"JW Vlaeyen","year":"2000","journal-title":"Pain"},{"issue":"1","key":"pone.0260715.ref015","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.math.2007.09.012","article-title":"Further examination of modifying patient-preferred movement and alignment strategies in patients with low back pain during symptomatic tests","volume":"14","author":"LR Van Dillen","year":"2009","journal-title":"Man Ther"},{"issue":"3","key":"pone.0260715.ref016","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuron.2007.07.012","article-title":"The cerebral signature for pain perception and its modulation","volume":"55","author":"I Tracey","year":"2007","journal-title":"Neuron"},{"key":"pone.0260715.ref017","volume-title":"Pain: The science of suffering","author":"PD Wall","year":"2000"},{"issue":"4","key":"pone.0260715.ref018","doi-asserted-by":"crossref","first-page":"e0154524","DOI":"10.1371\/journal.pone.0154524","article-title":"Motor Adaptations to Pain during a Bilateral Plantarflexion Task: Does the Cost of Using the Non-Painful Limb Matter?","volume":"11","author":"F Hug","year":"2016","journal-title":"PLoS One"},{"issue":"2\u20133","key":"pone.0260715.ref019","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(96)03304-0","article-title":"Habituation and the interference of pain with task performance","volume":"70","author":"G Crombez","year":"1997","journal-title":"Pain"},{"key":"pone.0260715.ref020","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1152\/ajplegacy.1929.88.4.581","article-title":"The role of fiber size in the establishment of a nerve block by pressure of cocaine","volume":"88","author":"H Gasser","year":"1929","journal-title":"Am J Physiol"},{"issue":"12","key":"pone.0260715.ref021","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1016\/j.pain.2012.07.032","article-title":"Attentional bias towards pain-related information diminishes the efficacy of distraction","volume":"153","author":"DM Van Ryckeghem","year":"2012","journal-title":"Pain"},{"issue":"6695","key":"pone.0260715.ref022","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/29528","article-title":"Signal-dependent noise determines motor planning","volume":"394","author":"CM Harris","year":"1998","journal-title":"Nature"},{"issue":"5","key":"pone.0260715.ref023","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/ana.25231","article-title":"Tuning in C-nociceptors to reveal mechanisms in chronic neuropathic pain","volume":"83","author":"R Jonas","year":"2018","journal-title":"Ann Neurol"},{"issue":"1\u20132","key":"pone.0260715.ref024","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pain.2007.07.019","article-title":"The effects of intra-oral pain on motor cortex neuroplasticity associated with short-term novel tongue-protrusion training in humans","volume":"132","author":"S Boudreau","year":"2007","journal-title":"Pain"},{"issue":"10","key":"pone.0260715.ref025","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1007\/s00421-012-2343-7","article-title":"Experimental muscle pain increases normalized variability of multidirectional forces during isometric contractions","volume":"112","author":"SE Salomoni","year":"2012","journal-title":"Eur J Appl Physiol"},{"issue":"3","key":"pone.0260715.ref026","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00421-012-2461-2","article-title":"Variability of three-dimensional forces increase during experimental knee pain","volume":"113","author":"SE Salomoni","year":"2013","journal-title":"Eur J Appl Physiol"},{"issue":"10","key":"pone.0260715.ref027","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.ejpain.2011.04.006","article-title":"The effect of pain on training-induced plasticity of the corticomotor system","volume":"15","author":"D Ingham","year":"2011","journal-title":"Eur J Pain"},{"issue":"6","key":"pone.0260715.ref028","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1177\/0956797610370160","article-title":"Pain relativity in motor control","volume":"21","author":"IT Kurniawan","year":"2010","journal-title":"Psychol Sci"},{"issue":"2","key":"pone.0260715.ref029","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neulet.2010.12.040","article-title":"Adaptation to bimanual asymmetric weights in isometric force coordination","volume":"490","author":"X Hu","year":"2011","journal-title":"Neurosci Lett"},{"key":"pone.0260715.ref030","article-title":"Task dependency of motor adaptations to an acute noxious stimulation","author":"F Hug","year":"2014","journal-title":"J Neurophysiol"},{"issue":"6971","key":"pone.0260715.ref031","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nature02169","article-title":"Bayesian integration in sensorimotor learning","volume":"427","author":"KP Kording","year":"2004","journal-title":"Nature"},{"issue":"5","key":"pone.0260715.ref032","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1115\/1.1392310","article-title":"Dynamic optimization of human walking","volume":"123","author":"FC Anderson","year":"2001","journal-title":"J Biomech Eng"},{"issue":"1","key":"pone.0260715.ref033","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1115\/1.2792265","article-title":"Optimal control of non-ballistic muscular movements: a constraint-based performance criterion for rising from a chair","volume":"117","author":"MG Pandy","year":"1995","journal-title":"J Biomech Eng"},{"issue":"1819","key":"pone.0260715.ref034","article-title":"Nature of the coupling between neural drive and force-generating capacity in the human quadriceps muscle","volume":"282","author":"F Hug","year":"2015","journal-title":"Proc Biol Sci"},{"issue":"Pt 15","key":"pone.0260715.ref035","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1242\/jeb.205.15.2175","article-title":"Energy-saving mechanisms in muscle: the minimization strategy","volume":"205","author":"KE Conley","year":"2002","journal-title":"J Exp Biol"},{"issue":"11","key":"pone.0260715.ref036","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/nn963","article-title":"Optimal feedback control as a theory of motor coordination","volume":"5","author":"E Todorov","year":"2002","journal-title":"Nat Neurosci"},{"issue":"3 Suppl","key":"pone.0260715.ref037","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central sensitization: implications for the diagnosis and treatment of pain","volume":"152","author":"CJ Woolf","year":"2011","journal-title":"Pain"},{"issue":"8","key":"pone.0260715.ref038","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.tics.2008.05.005","article-title":"Neurocognitive aspects of pain perception","volume":"12","author":"K Wiech","year":"2008","journal-title":"Trends Cogn Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0260715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T13:37:24Z","timestamp":1638970644000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0260715"}},"subtitle":[],"editor":[{"given":"YunJu","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,8]]},"references-count":38,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0260715","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,8]]}}}