{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:29:16Z","timestamp":1792297756290,"version":"4.4.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan","award":["BR10965164"],"award-info":[{"award-number":["BR10965164"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>First reported case of Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in Kazakhstan was identified in March 2020. Many specialized tertiary hospitals in Kazakhstan including National Research Cardiac Surgery Center (NRCSC) were re-organized to accept coronavirus disease 2019 (COVID-19) infected patients during summer months of 2020. Although many studies from worldwide reported their experience in treating patients with COVID-19, there are limited data available from the Central Asia countries. The aim of this study is to identify predictors of mortality associated with COVID-19 in NRCSC tertiary hospital in Nur-Sultan, Kazakhstan.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This is a retrospective cohort study of patients admitted to the NRCSC between June 1<jats:sup>st<\/jats:sup>\u2013August 31<jats:sup>st<\/jats:sup> 2020 with COVID-19. Demographic, clinical and laboratory data were collected from electronic records. In-hospital mortality was assessed as an outcome. Patients were followed-up until in-hospital death or discharge from the hospital. Descriptive statistics and factors associated with mortality were assessed using univariate and multivariate logistic regression models.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Two hundred thirty\u2014nine admissions were recorded during the follow-up period. Mean age was 57 years and 61% were males. Median duration of stay at the hospital was 8 days and 34 (14%) patients died during the hospitalization. Non-survivors were more likely to be admitted later from the disease onset, with higher fever, lower oxygen saturation and increased respiratory rate compared to survivors. Leukocytosis, lymphopenia, anemia, elevated liver and kidney function tests, hypoproteinemia, elevated inflammatory markers (C-reactive protein (CRP), ferritin, and lactate dehydrogenase (LDH)) and coagulation tests (fibrinogen, D-dimer, international normalized ratio (INR), and activated partial thromboplastin time (aPTT)) at admission were associated with mortality. Age (OR 1.2, CI:1.01\u20131.43), respiratory rate (OR 1.38, CI: 1.07\u20131.77), and CRP (OR 1.39, CI: 1.04\u20131.87) were determined to be independent predictors of mortality.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study describes 14% mortality rate from COVID-19 in the tertiary hospital. Many abnormal clinical and laboratory variables at admission were associated with poor outcome. Age, respiratory rate and CRP were found to be independent predictors of mortality. Our finding would help healthcare providers to predict the risk factors associated with high risk of mortality. Further investigations involving large cohorts should be provided to support our findings.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0261272","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T18:24:32Z","timestamp":1640197472000},"page":"e0261272","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mortality predictors of hospitalized patients with COVID-19: Retrospective cohort study from Nur-Sultan, Kazakhstan"],"prefix":"10.1371","volume":"16","author":[{"given":"Yuriy","family":"Pya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makhabbat","family":"Bekbossynova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abduzhappar","family":"Gaipov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur","family":"Lesbekov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur","family":"Kapyshev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidyn","family":"Kuanyshbek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainur","family":"Tauekelova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Litvinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-3837","authenticated-orcid":true,"given":"Aliya","family":"Sailybayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Vakhrushev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sarria-Santamera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"pone.0261272.ref001","unstructured":"Coronavirus Disease (COVID-19)\u2014events as they happen [Internet]. Who.int. 2021 [cited 12 February 2021]. https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/events-as-they-happen."},{"key":"pone.0261272.ref002","doi-asserted-by":"crossref","first-page":"100096","DOI":"10.1016\/j.lanepe.2021.100096","article-title":"Epidemiology, clinical characteristics, and virologic features of COVID-19 patients in Kazakhstan: A nation-wide retrospective cohort study","volume":"4","author":"S Yegorov","year":"2021","journal-title":"The Lancet Regional Health\u2014Europe"},{"issue":"7","key":"pone.0261272.ref003","doi-asserted-by":"crossref","first-page":"e281","DOI":"10.1016\/S2666-5247(20)30177-4","article-title":"COVID-19 response in central Asia","volume":"1","author":"V. Balakrishnan","year":"2020","journal-title":"The Lancet Microbe"},{"issue":"1","key":"pone.0261272.ref004","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-77698-4","article-title":"Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients","volume":"10","author":"M Bellan","year":"2020","journal-title":"Scientific Reports"},{"issue":"6","key":"pone.0261272.ref005","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/10408363.2020.1770685","article-title":"Biomarkers associated with COVID-19 disease progression","volume":"57","author":"G Ponti","year":"2020","journal-title":"Critical Reviews in Clinical Laboratory Sciences"},{"issue":"7","key":"pone.0261272.ref006","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1111\/anae.15072","article-title":"Hospital surge capacity in a tertiary emergency referral centre during the COVID -19 outbreak in Italy","volume":"75","author":"L Carenzo","year":"2020","journal-title":"Anaesthesia"},{"issue":"6","key":"pone.0261272.ref007","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s12630-020-01620-9","article-title":"Preparing for a COVID-19 pandemic: a review of operating room outbreak response measures in a large tertiary hospital in Singapore","volume":"67","author":"J Wong","year":"2020","journal-title":"Canadian Journal of Anesthesia\/Journal canadien d\u2019anesth\u00e9sie"},{"issue":"5","key":"pone.0261272.ref008","first-page":"271","article-title":"Clinical Characterization of 162 COVID-19 patients in Israel: Preliminary Report from a Large Tertiary Center","volume":"22","author":"E Itelman","year":"2020","journal-title":"The Israel Medical Association journal"},{"issue":"9","key":"pone.0261272.ref009","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/jmv.26035","article-title":"Increase in COVID-19 cases and case-fatality and case-recovery rates in Europe: A cross-temporal meta-analysis","volume":"92","author":"E. Karadag","year":"2020","journal-title":"Journal of Medical Virology"},{"key":"pone.0261272.ref010","unstructured":"\u201cInternational guidelines for certification and classification (coding) of covid-19 as cause of death\u201d [Internet]. WHO.int. 2020. https:\/\/www.who.int\/classifications\/icd\/Guidelines_Cause_of_Death_COVID-19.pdf."},{"issue":"6","key":"pone.0261272.ref011","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/jth.14859","article-title":"D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19","volume":"18","author":"L Zhang","year":"2020","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"pone.0261272.ref012","unstructured":"Coronavirus infection COVID-19 in adults [Internet]. Rcrz.kz. 2021 [cited 12 February 2021]. http:\/\/www.rcrz.kz\/index.php\/ru\/2017-03-12-10-51-13\/klinicheskie-protokoly."},{"issue":"1","key":"pone.0261272.ref013","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/kisup.2011.32","article-title":"Section 2: AKI Definition","volume":"2","year":"2012","journal-title":"Kidney International Supplements"},{"issue":"11","key":"pone.0261272.ref014","doi-asserted-by":"crossref","first-page":"e0241742","DOI":"10.1371\/journal.pone.0241742","article-title":"Predictors of in-hospital COVID-19 mortality: A comprehensive systematic review and meta-analysis exploring differences by age, sex and health conditions","volume":"15","author":"A Mesas","year":"2020","journal-title":"PLOS ONE"},{"issue":"1","key":"pone.0261272.ref015","doi-asserted-by":"crossref","first-page":"6317","DOI":"10.1038\/s41467-020-19741-6","article-title":"Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU 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New York City","volume":"21","author":"S Chilimuri","year":"2020","journal-title":"Western Journal of Emergency Medicine"},{"issue":"7","key":"pone.0261272.ref019","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1515\/cclm-2020-0369","article-title":"Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis","volume":"58","author":"B Henry","year":"2020","journal-title":"Clinical Chemistry and Laboratory Medicine (CCLM)"},{"issue":"1","key":"pone.0261272.ref020","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/16078454.2020.1833435","article-title":"Hematologic predictors of mortality in hospitalized patients with COVID-19: a comparative study","volume":"25","author":"S Mousavi","year":"2020","journal-title":"Hematology"},{"issue":"1","key":"pone.0261272.ref021","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s13054-020-03098-9","article-title":"Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China","volume":"24","author":"J Xu","year":"2020","journal-title":"Critical Care"},{"issue":"15","key":"pone.0261272.ref022","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/cid\/ciaa248","article-title":"Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China","volume":"71","author":"C Qin","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"7","key":"pone.0261272.ref023","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1515\/cclm-2020-0369","article-title":"Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 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