{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:47:12Z","timestamp":1776206832039,"version":"3.50.1"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020621","name":"Seoul St. Mary's Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020621","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Whether herpes zoster infection (HZI) affects laryngitis incidence remains unknown.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>The purpose of this population-based retrospective study was to analyze the relationship between laryngitis and HZI using data from the Korean Health Insurance Review and Assessment Service\u2014National Sample Cohort.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This study analyzed 1,197,093 medical claim codes from 2018. Patients with HZI (ICD-10: B02) were retrospectively identified. Laryngeal diseases were defined by ICD-10 codes for five subgroups: 1) malignant disease, 2) benign disease, 3) vocal cord palsy, 4) inflammatory disease, and 5) reflux disease.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>Among the Korean population older than 20 years, 12,809 experienced HZI. Subjects with HZI were more likely to be older (mean age: 51.54 years vs. 48.06 years, <jats:italic>p<\/jats:italic> &lt;0.0001). The proportion of subjects with laryngeal disease was higher in those with HZI than in those without HZI (55.55% vs. 41.37%, <jats:italic>p<\/jats:italic> &lt;0.0001). Laryngeal disease was significantly associated with HZI in multiple regression analysis (odds ratio (OR) = 1.77, 95% confidence interval: 1.71\u20131.84) after adjusting for age, sex, hypertension, diabetes, dyslipidemia, ischemic heart disease, cerebral stroke, and depression. Among laryngeal disease subgroups, inflammatory disease (OR = 1.05; 95% CI: 1.01\u20131.09) and reflux (OR = 1.20; 95% CI: 1.15\u20131.25) were associated with HZI.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>HZI is independently associated with laryngitis. Results of this study have implications for etiological investigations and prevention strategies for laryngitis.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0261366","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T18:26:14Z","timestamp":1639160774000},"page":"e0261366","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["The risk of laryngitis with herpes zoster infection: A nested case-control study using data from the Korean National Sample Cohort"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-0974","authenticated-orcid":true,"given":"Young-Hoon","family":"Joo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Ook","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-4676","authenticated-orcid":true,"given":"Young Joon","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hoon","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-3250","authenticated-orcid":true,"given":"Kyoung Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"pone.0261366.ref001","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0892-1997(02)00131-5","article-title":"Laryngeal herpes: a case report","volume":"16","author":"JA Pinto","year":"2002","journal-title":"J Voice"},{"key":"pone.0261366.ref002","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1016\/j.vaccine.2019.07.086","article-title":"The changing epidemiology of herpes zoster over a decade in South Korea, 2006\u20132015","volume":"37","author":"JK Choi","year":"2019","journal-title":"Vaccine"},{"key":"pone.0261366.ref003","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.otc.2007.11.012","article-title":"Laryngitis\u2014diagnosis and management","volume":"41","author":"OE Tulunay","year":"2008","journal-title":"Otolaryngol Clin North 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