{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:05:50Z","timestamp":1740146750318,"version":"3.37.3"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016R1D1A1B03931961"],"award-info":[{"award-number":["2016R1D1A1B03931961"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1C1C1002243"],"award-info":[{"award-number":["2019R1C1C1002243"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1F1A1066491"],"award-info":[{"award-number":["2020R1F1A1066491"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Despite the importance of<jats:italic>Helicobacter pylori<\/jats:italic>infection and portal hypertension (PH)-associated gastrointestinal (GI) diseases, such as esophageal varices and portal hypertensive gastropathy (PHG), the impact of<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>infection on PH-related GI complications has not yet been elucidated. This meta-analysis investigated the association between<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>infection and the risk of PH-related GI complications. An electronic search for original articles published before May 2020 was performed using PubMed, EMBASE, and the Cochrane Library. Independent reviewers conducted the article screening and data extraction. We used the generic inverse variance method for the meta-analysis, and Begg\u2019s rank correlation test and Egger\u2019s regression test to assess publication bias. A total of 1,148 cases of<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>infection and 1,231 uninfected controls were included from 13 studies.<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>infection had no significant association with esophageal varices [relative risk (RR) = 0.96, 95% confidence interval (CI) = 0.87\u20131.06 for all selected studies; RR = 0.95, 95% CI = 0.84\u20131.07 for cohort studies; odds ratio (OR) = 0.96, 95% CI = 0.60\u20131.54 for case-control studies]. Although<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>infection was significantly associated with PHG in case-control studies [OR = 1.86, 95% CI = 1.17\u20132.96], no significant differences were found in the cohort studies [RR = 0.98, 95% CI = 0.91\u20131.05] or all studies combined [RR = 1.18, 95% CI = 0.93\u20131.52]. In conclusion,<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>infection was not associated with the risk of PH-related GI complications. Clinicians should carefully treat cirrhotic patients with PH-related GI complications, regardless of<jats:italic>H<\/jats:italic>.<jats:italic>pylori<\/jats:italic>infection.<\/jats:p>","DOI":"10.1371\/journal.pone.0261448","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T19:35:30Z","timestamp":1642793730000},"page":"e0261448","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis"],"prefix":"10.1371","volume":"17","author":[{"given":"Yu Kyung","family":"Jun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong 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