{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:27:29Z","timestamp":1791829649785,"version":"4.3.4"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Baden-Wuerttemberg Ministry of Science, Research and Art"},{"DOI":"10.13039\/501100002714","name":"University of Freiburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002714","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>International guidelines propose color Doppler ultrasound (CDUS) and contrast-enhanced computed tomography (CT) as primary imaging techniques in the diagnosis of acute splanchnic vein thrombosis. However, their reliability in this context is poorly investigated. Therefore, the aim of our study was to validate CDUS and CT in the radiologic assessment of acute splanchnic vein thrombosis, using direct transjugular spleno-portography as gold standard.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>49 patients with non-malignant acute splanchnic vein thrombosis were included in a retrospective, multicenter analysis. The thrombosis\u2019 extent in five regions of the splanchnic venous system (right and left intrahepatic portal vein, main trunk of the portal vein, splenic vein, superior mesenteric vein) and the degree of thrombosis (patent, partial thrombosis, complete thrombosis) were assessed by portography, CDUS and CT in a blinded manner. Reliability of CDUS and CT with regard to portography as gold standard was analyzed by calculating Cohen\u2019s kappa.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Results of CDUS and CT were consistent with portography in 76.6% and 78.4% of examinations, respectively. Cohen\u2019s kappa demonstrated that CDUS and CT delivered almost equally reliable results with regard to the portographic gold standard (k = 0.634 [p &lt; 0.001] vs. k = 0.644 [p &lt; 0.001]). In case of findings non-consistent with portography there was no clear trend to over- or underestimation of the degree of thrombosis in both CDUS (60.0% vs. 40.0%) and CT (59.5% vs. 40.5%).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>CDUS and CT are equally reliable tools in the radiologic assessment of non-malignant acute splanchnic vein thrombosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0261499","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T18:32:53Z","timestamp":1640025173000},"page":"e0261499","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Validation of color Doppler ultrasound and computed tomography in the radiologic assessment of non-malignant acute splanchnic vein thrombosis"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3623-7857","authenticated-orcid":true,"given":"Lukas","family":"Sturm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Bettinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Klinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Krauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Patrick","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Caca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Thimme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schultheiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"pone.0261499.ref001","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1056\/NEJMra010076","article-title":"Mesenteric Venous Thrombosis","volume":"345","author":"S Kumar","year":"2001","journal-title":"N Engl J Med"},{"key":"pone.0261499.ref002","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/apt.15479","article-title":"A stepwise thrombolysis regimen in the management of acute portal vein thrombosis in patients with evidence of intestinal ischaemia","volume":"50","author":"A Benmassaoud","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"pone.0261499.ref003","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/01.RVI.0000156265.79960.86","article-title":"Transcatheter Thrombolytic Therapy for Acute Mesenteric and Portal Vein Thrombosis","volume":"16","author":"M Hollingshead","year":"2005","journal-title":"J Vasc Interv Radiol"},{"key":"pone.0261499.ref004","article-title":"A prospective, multicentre study in acute noncirrhotic, nonmalignant portal vein thrombosis: comparison of medical and interventional treatment","author":"M R\u00f6ssle","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"pone.0261499.ref005","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/hep.23397","article-title":"Degree of portal vein thrombosis","volume":"51","author":"X Qi","year":"2010","journal-title":"Hepatology"},{"key":"pone.0261499.ref006","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.jhep.2010.06.004","article-title":"Revising consensus in portal hypertension: Report of the Baveno v consensus workshop on methodology of diagnosis and therapy in portal hypertension","author":"R. 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