{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:13:53Z","timestamp":1770707633134,"version":"3.49.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Medicinal plants represent a great source of antimicrobial and phytochemical constituents which are increasingly used to treat microbial infections and other ailments such as tuberculosis, anemia, and trachoma. Despite the use of antibiotics, antimicrobial resistance continues to be a world issue, in as much as nutrition. This study investigated the presence of phytochemicals, proximate compositions, and antimicrobial activity of methanolic extract of <jats:italic>Carapa procera<\/jats:italic> bark. The bark of <jats:italic>Carapa procera<\/jats:italic> was collected, cleaned and air dried for 72 h. The powder obtained was treated with diethyl ether and soaked in methanol (99%) for 72 h to obtain crude extract. The extract was used to test for the presence of phytochemicals and antimicrobial activities. The raw bark was used for proximate analysis. The result showed presence of steroids, tannins and saponins, but no alkaloids present. The 100 mg\/mL extract had the highest inhibition zone on all tested organisms from 24.00 \u00b1 0.94 to 26.67 \u00b1 1.18, and 50 mg\/mL showed the least (16.67 \u00b1 1.24) on <jats:italic>Candida albicans<\/jats:italic>. <jats:italic>Staphylococcus aureus<\/jats:italic> showed the lowest minimum inhibition concentration (MIC) of 3.12 mg\/mL, whereas the Gram-negative bacteria exhibited variations in their sensitivity with <jats:italic>E<\/jats:italic>. <jats:italic>coli<\/jats:italic> having the highest MIC of 25 mg\/mL. The extract had high MIC (6.25 mg\/mL) on <jats:italic>Candida albicans<\/jats:italic> than clotrimazole (50 mg\/mL). The proximate compositions of <jats:italic>Carapa procera<\/jats:italic> were moisture (6.07 \u00b1 0.07%), ash (12.46 \u00b1 0.46%), crude protein (9.54 \u00b1 0.12%), crude fat (1.42 \u00b1 0.06%) and carbohydrate (70.50 \u00b1 0.35%). The energy value was 1413.17 kj. Thus, <jats:italic>Carapa procera<\/jats:italic> possesses both antimicrobial and nutritional potentials worth exploring and domesticating for sustainable management and conservation.<\/jats:p>","DOI":"10.1371\/journal.pone.0261755","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T18:51:26Z","timestamp":1640285486000},"page":"e0261755","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Phytochemical and proximate content of Carapa procera bark and its antimicrobial potential against selected pathogens"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3318-3926","authenticated-orcid":true,"given":"Derrick Ansah","family":"Owusu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-106X","authenticated-orcid":true,"given":"Alfred Elikem Kwami","family":"Afedzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-5990","authenticated-orcid":true,"given":"Lydia","family":"Quansah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"pone.0261755.ref001","first-page":"14","article-title":"A review on medicinal plants and herbs of Uttrakhand (India): its traditional, ethanomedicinal and antimicrobial potential","author":"Singh A Navneet","year":"2016","journal-title":"Nature and Science"},{"key":"pone.0261755.ref002","first-page":"168","article-title":"Phytochemistry of Medicinal Plants","volume":"1","author":"M Saxena","year":"2013","journal-title":"J Pharm Phytochem"},{"key":"pone.0261755.ref003","volume-title":"Review on Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations. 2014","author":"J. 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