{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:49:12Z","timestamp":1784242152962,"version":"3.55.0"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["ALLRP 549529"],"award-info":[{"award-number":["ALLRP 549529"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","award":["IT27597"],"award-info":[{"award-number":["IT27597"]}],"id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","award":["IT27597"],"award-info":[{"award-number":["IT27597"]}],"id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Cannabis legalization in North America has coincided with an increase in reports of cannabis-induced toxicosis in pets, but the magnitude of this problem, as well as outcomes of these incidents remain unknown. Therefore, we examined the frequency, diagnostic criteria, clinical signs, and prognoses of cannabis toxicoses in pets in North America. We conducted an online survey between January, 2021 and April, 2021 targeting veterinarians practicing in Canada and the United States (US). Out of the 251 study participants, 191 practiced in Canada. Cannabis toxicosis was most commonly reported in dogs (n = 226 veterinarians), and the number of toxicosis cases increased significantly in Canada (p&lt;0.0001) and the US (p = 0.002) after October, 2018. Frequently reported clinical signs of cannabis toxicosis included: urinary incontinence (n = 195), disorientation (n = 182), ataxia (n = 178), lethargy (n = 150), hyperesthesia (n = 134), and bradycardia (n = 112). Edibles were most commonly suspected to be the cause of toxicosis (n = 116). The most common route of exposure was ingestion (n = 135), while the most cited reason was ingestion while unattended (n = 135). Cannabis toxicosis was mostly diagnosed using supportive clinical signs (n = 229), the most common treatment was outpatient monitoring (n = 182), and pets were most often treated as out-patients (n = 103). The legalization of cannabis use in Canada and the US is likely an important factor associated with the increased cannabis toxicosis cases in pets; however, the legal status may also increase reporting. The medicinal use of cannabis by pet-owners for pets may also contribute to a portion of the reported toxicoses. Most pets that experienced cannabis toxicosis recovered completely, suggesting that most cannabis toxicoses do not result in long-term ill effects. Even though some deaths (n = 16) were reported in association with cannabis toxicosis, the presence of confounders such as toxins, and underlying conditions cannot be ruled out, emphasizing the need for rigorous controlled laboratory studies to investigate this important issue.<\/jats:p>","DOI":"10.1371\/journal.pone.0261909","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T13:24:33Z","timestamp":1650461073000},"page":"e0261909","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence and characteristics of cannabis-induced toxicoses in pets: Results from a survey of veterinarians in North America"],"prefix":"10.1371","volume":"17","author":[{"given":"Richard Quansah","family":"Amissah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0156-4206","authenticated-orcid":true,"given":"Nadine A.","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-2275","authenticated-orcid":true,"given":"Jibran","family":"Khokhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"pone.0261909.ref001","unstructured":"United Nations Office on Drugs and Crime. Cannabis and Hallucinogens. World Drug Report: United Nations; 2019. p. 76."},{"issue":"7","key":"pone.0261909.ref002","doi-asserted-by":"crossref","first-page":"e0219430","DOI":"10.1371\/journal.pone.0219430","article-title":"A survey of veterinary student attitudes concerning whether marijuana could have therapeutic value for animals","volume":"14","author":"NA Vogt","year":"2019","journal-title":"PloS one"},{"issue":"7","key":"pone.0261909.ref003","first-page":"749","article-title":"Canadian dog owners\u2019 use and perceptions of cannabis products","volume":"60","author":"LR Kogan","year":"2019","journal-title":"Can Vet J"},{"issue":"3","key":"pone.0261909.ref004","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3390\/ani11030892","article-title":"Cannabis, Cannabidiol Oils and Tetrahydrocannabinol\u2014What Do Veterinarians Need to Know?","volume":"11","author":"N De Briyne","year":"2021","journal-title":"Animals"},{"issue":"6","key":"pone.0261909.ref005","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1476-4431.2012.00818.x","article-title":"Evaluation of trends in marijuana toxicosis in dogs living in a state with legalized medical marijuana: 125 dogs (2005\u20132010)","volume":"22","author":"SD Meola","year":"2012","journal-title":"J Vet Emerg Crit Care (San Antonio)"},{"key":"pone.0261909.ref006","unstructured":"Stillabower A. Marijuana Toxicity in Pets: Pet Poison Helpline; 2019 https:\/\/www.petpoisonhelpline.com\/pet-safety-tips\/marijuana-toxicity-pets\/."},{"key":"pone.0261909.ref007","unstructured":"American Society for the Prevention of Cruelty to Animals. Marijuana Toxicosis in Animals. 2019 https:\/\/www.aspcapro.org\/resource\/marijuana-toxicosis-animals. Accessed 9th August 2021."},{"key":"pone.0261909.ref008","unstructured":"Canadian Veterinary Medical Association. News Release: National Veterinary Association Acquires Cannabis Pet Poisoning Statistics for Canada. 2019. https:\/\/www.canadianveterinarians.net\/documents\/national-veterinary-association-acquires-cannabis-pet-poisoning-statistics-for-canada. Accessed 9th August 2021."},{"key":"pone.0261909.ref009","article-title":"Marijuana exposure in animals","volume":"437","author":"CW Donaldson","year":"2002","journal-title":"Veterinary Medicine"},{"key":"pone.0261909.ref010","unstructured":"Canadian Animal Health Institute. 2020 Canadian pet population figures released: Canadian Animal Health Institute; 2021 [updated 15th February 2021. https:\/\/cahi-icsa.ca\/news\/2020-canadian-pet-population-figures-released."},{"issue":"2","key":"pone.0261909.ref011","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1748-5827.2010.01017.x","article-title":"Cannabis intoxication in three Green iguanas (Iguana iguana)","volume":"52","author":"SJ Girling","year":"2011","journal-title":"J Small Anim Pract"},{"key":"pone.0261909.ref012","article-title":"Coma in a ferret after ingestion of cannabis","author":"R. Smith","year":"1988","journal-title":"Veterinary and human toxicology"},{"issue":"4","key":"pone.0261909.ref013","doi-asserted-by":"crossref","first-page":"e0250323","DOI":"10.1371\/journal.pone.0250323","article-title":"The impact of state cannabis legislation, county-level socioeconomic and dog-level characteristics on reported cannabis poisonings of companion dogs in the USA (2009\u20132014)","volume":"16","author":"M Howard-Azzeh","year":"2021","journal-title":"PLoS One"},{"issue":"6","key":"pone.0261909.ref014","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/2045125312457586","article-title":"Cannabis, a complex plant: different compounds and different effects on individuals","volume":"2","author":"Z Atakan","year":"2012","journal-title":"Therapeutic advances in psychopharmacology"},{"issue":"5\u20136","key":"pone.0261909.ref015","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/07352689.2016.1265360","article-title":"Medicinal uses of marijuana and 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Trouve","year":"1999"},{"issue":"3","key":"pone.0261909.ref028","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.2042-7158.1974.tb09252.x","article-title":"Role of the central autonomic nervous system in the hypotension and bradycardia induced by (-)-delta 9-trans-tetrahydrocannabinol","volume":"26","author":"RR Vollmer","year":"1974","journal-title":"J Pharm Pharmacol"},{"issue":"2","key":"pone.0261909.ref029","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0009-3084(99)00124-3","article-title":"A sensitive endocannabinoid assay. 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Pharmacol"},{"issue":"8","key":"pone.0261909.ref035","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/cbdv.200790152","article-title":"Human cannabinoid pharmacokinetics","volume":"4","author":"MA Huestis","year":"2007","journal-title":"Chem Biodivers"},{"issue":"1","key":"pone.0261909.ref036","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.ne.15.030192.002155","article-title":"The cerebellum and the adaptive coordination of movement","volume":"15","author":"WT Thach","year":"1992","journal-title":"Annual review of neuroscience"},{"issue":"5","key":"pone.0261909.ref037","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1073\/pnas.87.5.1932","article-title":"Cannabinoid receptor localization in brain","volume":"87","author":"M Herkenham","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pone.0261909.ref038","first-page":"629","article-title":"Cannabinoid CB(1) receptor agonists produce cerebellar dysfunction in mice","volume":"297","author":"S Patel","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"issue":"10","key":"pone.0261909.ref039","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/00006231-199213100-00011","article-title":"Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome","volume":"13","author":"M Ichise","year":"1992","journal-title":"Nucl Med Commun"},{"issue":"2","key":"pone.0261909.ref040","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1006\/bbrc.1996.5919","article-title":"High uptake of [2-11C]acetyl-L-carnitine into the brain: a PET study","volume":"231","author":"H Kuratsune","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0261909.ref041","first-page":"98","article-title":"Neuroscientific model of motivational process","volume":"4","author":"SI Kim","year":"2013","journal-title":"Front Psychol"},{"issue":"2","key":"pone.0261909.ref042","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0306-4522(96)00428-9","article-title":"Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain","volume":"77","author":"M Glass","year":"1997","journal-title":"Neuroscience"},{"issue":"7","key":"pone.0261909.ref043","doi-asserted-by":"crossref","first-page":"e0181064","DOI":"10.1371\/journal.pone.0181064","article-title":"Spatial distribution of cannabinoid receptor type 1 (CB1) in normal canine central and peripheral nervous system","volume":"12","author":"J Freundt-Revilla","year":"2017","journal-title":"PLoS One"},{"issue":"35","key":"pone.0261909.ref044","doi-asserted-by":"crossref","first-page":"11072","DOI":"10.1073\/pnas.1504242112","article-title":"Brain system for mental orientation in space, time, and person","volume":"112","author":"M 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