{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T08:09:41Z","timestamp":1771574981397,"version":"3.50.1"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea","award":["NRF-2020R1F1A1074898"],"award-info":[{"award-number":["NRF-2020R1F1A1074898"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To analyze choroidal structure using subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) in Macular Telangiectasia (MacTel) type 2.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Medical records of 43 eyes with MacTel type 2 and 30 sex and age-matched healthy eyes were retrospectively reviewed. Their SFCT and CVI were measured using the SS-OCT scan passing through the central fovea and image binarization. The difference in baseline SFCT and CVI from each group and their yearly changes up to second year of follow up were analyzed. The baseline characteristics of the groups were also compared.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The baseline characteristics, including CVI and SFCT, of the MacTel group and the control group were not significantly different, except for BCVA. The mean CVI of MacTel group were 64.59 \u00b1 2.92%, 63.76 \u00b1 2.67%, and 62.97 \u00b1 2.74% (<jats:italic>p<\/jats:italic> &lt; 0.001) whereas that of control group were 63.33 \u00b1 2.45%, 63.04 \u00b1 2.46%, and 63.43 \u00b1 2.25% (<jats:italic>p<\/jats:italic> = 0.636) at baseline, 1 and 2 years, respectively. The mean SFCT of MacTel group were 324.65 \u00b1 89.65\u03bcm, 326.14 \u00b1 93.11\u03bcm, and 322.65 \u00b1 91.77\u03bcm (<jats:italic>p<\/jats:italic> = 0.436), whereas that of control group were 304.30 \u00b1 51.86 \u03bcm, 300.86 \u00b1 52.64\u03bcm, and 298.55 \u00b1 53.71\u03bcm (<jats:italic>p<\/jats:italic> = 0.275) at baseline, 1 and 2 years, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>CVI decreases at a faster rate in MacTel type 2 in comparison with healthy subjects. This may suggest possible choroidal involvement in the progression of MacTel type 2.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0262112","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T17:50:00Z","timestamp":1649353800000},"page":"e0262112","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Choroidal vascularity index change in macular telangiectasia type 2"],"prefix":"10.1371","volume":"17","author":[{"given":"Heejeong","family":"Chun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae 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