{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:23:32Z","timestamp":1777508612212,"version":"3.51.4"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R24AI152598-01"],"award-info":[{"award-number":["1R24AI152598-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"US Military HIV Research Program","award":["W81XWH-11-2-0174 and W81XWH-18-2-0040"],"award-info":[{"award-number":["W81XWH-11-2-0174 and W81XWH-18-2-0040"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Washington, DC, and sub-Saharan Africa are both affected by generalized HIV epidemics. However, care for persons living with HIV (PLWH) and clinical outcomes may differ in these geographically and culturally diverse areas. We compared patient and clinical site characteristics among adult persons living with HIV (PLWH) enrolled in two longitudinal HIV cohort studies\u2014the African Cohort Study (AFRICOS) and the DC Cohort.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The DC Cohort is a clinic-based city-wide longitudinal cohort comprised of PLWH attending 15 HIV clinics in Washington, DC. Patients\u2019 socio-demographic characteristics, clinical evaluations, and laboratory data are retrospectively collected from electronic medical records and limited manual chart abstraction. AFRICOS is a prospective observational cohort of PLWH and uninfected volunteers attending 12 select HIV care and treatment facilities in Nigeria, Kenya, Uganda and Tanzania. AFRICOS study participants are a subset of clinic patients who complete protocol-specific visits every 6 months with history and physical examination, questionnaire administration, and blood\/sputum collection for ascertainment of HIV outcomes and comorbidities, and neurocognitive and functional assessments. Among participants aged \u2265 18 years, we generated descriptive statistics for demographic and clinical characteristics at enrollment and follow up and compared them using bivariable analyses.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The study sample included 2,774 AFRICOS and 8,420 DC Cohort participants who enrolled from January 2013 (AFRICOS)\/January 2011 (DC Cohort) through March 2018. AFRICOS participants were significantly more likely to be women (58.8% vs 27.1%) and younger (83.3% vs 61.1% aged &lt; 50 years old) and significantly less likely to be MSM (only 0.1% of AFRICOS population reported MSM risk factor) than DC Cohort. Similar rates of current viral suppression (about 75% of both samples), hypertension, hepatitis B coinfection and alcohol use were observed. However, AFRICOS participants had significantly higher rates of CD4&lt;200 and tuberculosis and significantly lower rates of obesity, DM, hepatitis C coinfection and syphilis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>With similar viral suppression outcomes, but many differences between our cohorts noted, the combined sample provides unique opportunities to assess and compare HIV care and treatment outcomes in the U.S. and sub-Saharan Africa. Comparing these two cohorts may inform care and treatment practices and may pave the way for future pathophysiologic analyses.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0262204","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T17:25:37Z","timestamp":1649093137000},"page":"e0262204","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical similarities and differences between two large HIV cohorts in the United States and Africa"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-3845","authenticated-orcid":true,"given":"Anne K.","family":"Monroe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina S.","family":"Polyak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda D.","family":"Castel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allahna L.","family":"Esber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan E.","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonah","family":"Maswai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Owuoth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Maganga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Bahemana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakubu","family":"Adamu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Iroezindu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Kibuuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Kiweewa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan E.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5947-265X","authenticated-orcid":true,"given":"Trevor A.","family":"Crowell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Ake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the DC Cohort Executive Committee and AFRICOS Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"pone.0262204.ref001","unstructured":"https:\/\/www.who.int\/hiv\/pub\/guidelines\/arv2013\/intro\/keyterms\/en\/"},{"key":"pone.0262204.ref002","unstructured":"Avert. HIV and AIDS in Nigeria. https:\/\/www.avert.org\/professionals\/hiv-around-world\/sub-saharan-africa\/nigeria. Accessed 1\/29\/19"},{"key":"pone.0262204.ref003","unstructured":"Avert. HIV and AIDS in East and Southern Africa Regional Overview. https:\/\/www.avert.org\/professionals\/hiv-around-world\/sub-saharan-africa\/overview. Accessed 1\/29\/19"},{"issue":"1","key":"pone.0262204.ref004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7448\/IAS.19.1.21270","article-title":"High prevalence of HIV, chlamydia and gonorrhoea among men who have sex with men and transgender women attending trusted community centres in Abuja and Lagos, Nigeria","volume":"19","author":"B Keshinro","year":"2016","journal-title":"J Int AIDS Soc"},{"key":"pone.0262204.ref005","unstructured":"Annual Epidemiology & Surveillance Report: Data Through December 2018. Washington, DC: District of Columbia Department of Health; HIV\/AIDS, Hepatitis, STD, & TB Administration, 2019. https:\/\/dchealth.dc.gov\/publication\/hahsta-annual-epidemiology-surveillance-report-2019. Accessed February 24, 2020."},{"key":"pone.0262204.ref006","unstructured":"UNAIDS. 90-90-90 An Ambitious Target to Help end the HIV epidemic."},{"key":"pone.0262204.ref007","unstructured":"90\/90\/90\/50 Plan Ending the HIV Epidemic in the District of Columbia by 2020."},{"issue":"5","key":"pone.0262204.ref008","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/cid\/ciy989","article-title":"Persistent Low-level Viremia Predicts Subsequent Virologic Failure: Is It Time to Change the Third 90?","volume":"69","author":"A Esber","year":"2019","journal-title":"Clin Infect Dis"},{"key":"pone.0262204.ref009","article-title":"PC. Noninfectious Comorbidity in the African Cohort Study (AFRICOS)","author":"J Ake","year":"2018","journal-title":"Clin Infect Dis"},{"issue":"1","key":"pone.0262204.ref010","first-page":"e23","volume":"4","author":"AD Castel","year":"2018","journal-title":"Defining Care Patterns and Outcomes Among Persons Living with HIV in Washington, DC: Linkage of Clinical Cohort and Surveillance Data"},{"issue":"3","key":"pone.0262204.ref011","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/jamia\/ocv176","article-title":"Development of a large urban longitudinal HIV clinical cohort using a web-based platform to merge electronically and manually abstracted data from disparate medical record systems: Technical challenges and innovative solutions","volume":"23","author":"AE Greenberg","year":"2016","journal-title":"J Am Med Informatics Assoc"},{"key":"pone.0262204.ref012","first-page":"1","author":"AL Esber","year":"2020","journal-title":"Decreasing time to antiretroviral therapy initiation after HIV diagnosis in a clinic-based observational cohort study in four African countries"},{"issue":"2","key":"pone.0262204.ref013","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/QAI.0000000000000589","article-title":"Brief report: Time from infection with the human immunodeficiency virus to diagnosis, United States","volume":"69","author":"HI Hall","year":"2015","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"3","key":"pone.0262204.ref014","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/09540121.2015.1096891","article-title":"Delayed entry into HIV medical care in a nationally representative sample of HIV-infected adults receiving medical care in the USA","volume":"28","author":"M Robertson","year":"2016","journal-title":"AIDS Care\u2014Psychol Socio-Medical Asp AIDS\/HIV"},{"key":"pone.0262204.ref015","unstructured":"Global Trends in CD4 Cell Count at the Start of Antiretroviral Therapy: Collaborative Study of Treatment Programs. CID."},{"key":"pone.0262204.ref016","unstructured":"CDC. Understanding the HIV Care Continuum https:\/\/www.cdc.gov\/hiv\/pdf\/library\/factsheets\/cdc-hiv-care-continuum.pdf. Accessed 1\/29\/19."},{"key":"pone.0262204.ref017","unstructured":"WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. https:\/\/www.who.int\/hiv\/pub\/arv\/summary-recommendations.pdf. Accessed 1\/29\/19."},{"key":"pone.0262204.ref018","unstructured":"Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV. https:\/\/aidsinfo.nih.gov\/guidelines\/html\/1\/adult-and-adolescent-arv\/0. Accessed 1\/29\/19."},{"issue":"10","key":"pone.0262204.ref019","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/hiv.12516","article-title":"High burden of metabolic comorbidities in a citywide cohort of HIV outpatients: evolving health care needs of people aging with HIV in Washington, DC","volume":"18","author":"ME Levy","year":"2017","journal-title":"HIV Med"},{"issue":"Suppl 1","key":"pone.0262204.ref020","first-page":"S5","article-title":"Noncommunicable diseases among HIV-infected persons in low-income and middle-income countries: a systematic review and meta-analysis","volume":"32","author":"NIH HIV\/NCD Project Disease Condition Technical Operating Group","year":"2018","journal-title":"AIDS"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0262204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T17:26:00Z","timestamp":1649093160000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0262204"}},"subtitle":[],"editor":[{"given":"John S","family":"Lambert","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,4]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0262204","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,4]]}}}