{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:18:49Z","timestamp":1782184729790,"version":"3.54.5"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Whether fluid overload is associated with vascular stiffness parameters in hemodialysis (HD) patients has not been fully elucidated. We hypothesized that interdialytic fluid accumulation increases vascular stiffness parameters, which improves with intradialytic ultrafiltration.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Fluid overload and vascular stiffness parameters were assessed in 39 HD patients (20 with and 19 without fluid overload) and compared to 26 healthy controls. Fluid status was assessed 15 minutes before the mid-week HD session by bio-impedance spectroscopy. Following this, ambulatory pulse wave velocity (PWV) and augmentation index (AIx) were measured for 24 hours before another mid-week HD session and then for 5 hours starting 30 minutes before and ending 30 minutes after the session.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>HD patients had significant fluid overload compared to healthy controls (2.0\u00b12.4 vs. -0.2\u00b10.6 L; P&lt;0.001) and baseline PWV was higher (10.3\u00b11.7 vs. 8.8\u00b11.4 m\/s; P&lt;0.001). There was no significant difference between PWV and AIx in fluid overloaded and non-fluid overloaded HD patients prior to, or during the HD session. AIx of non-fluid overloaded HD patients improved after the HD session (P = 0.04). Average 24-hour AIx was higher in fluid overloaded HD patients (P&lt;0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Inter- and intradialytic changes in fluid volume were only weakly related to vascular stiffness parameters in HD patients. Although there was a modest reduction in AIx in non-fluid overloaded HD patients after the dialysis session, fluid removal did not improve vascular stiffness parameters during the HD session. We speculate that the effect of fluid overload correction on vascular stiffness parameters requires long-term adjustments in the vasculature.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0262519","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T18:49:43Z","timestamp":1643914183000},"page":"e0262519","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Inter- and intradialytic fluid volume changes and vascular stiffness parameters in patients on hemodialysis"],"prefix":"10.1371","volume":"17","author":[{"given":"Aya","family":"Lafta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Ukrainetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Davison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminu","family":"Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7296-1148","authenticated-orcid":true,"given":"Branko","family":"Braam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"issue":"11","key":"pone.0262519.ref001","doi-asserted-by":"crossref","first-page":"e111000","DOI":"10.1371\/journal.pone.0111000","article-title":"Fluid Overload, Pulse Wave Velocity, and Ratio of Brachial Pre-Ejection Period to Ejection Time in Diabetic and Non-Diabetic Chronic Kidney Disease","volume":"9","author":"Y-C Tsai","year":"2014","journal-title":"PLOS ONE"},{"issue":"5","key":"pone.0262519.ref002","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/ndt\/gfn707","article-title":"The mortality risk of overhydration in haemodialysis patients","volume":"24","author":"V Wizemann","year":"2009","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"18","key":"pone.0262519.ref003","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1161\/01.CIR.99.18.2434","article-title":"Impact of aortic stiffness on survival in end-stage renal disease","volume":"99","author":"J Blacher","year":"1999","journal-title":"Circulation"},{"issue":"7","key":"pone.0262519.ref004","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.CIR.103.7.987","article-title":"Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure","volume":"103","author":"AP Guerin","year":"2001","journal-title":"Circulation"},{"issue":"5","key":"pone.0262519.ref005","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1161\/CIRCULATIONAHA.108.807362","article-title":"Fluid Retention is Associated with Cardiovascular Mortality in Chronic Hemodialysis Patients","volume":"119","author":"K Kalantar-Zadeh","year":"2009","journal-title":"Circulation"},{"issue":"6","key":"pone.0262519.ref006","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.2215\/CJN.01110307","article-title":"Long-term survival of incident hemodialysis patients who are hospitalized for congestive heart failure, pulmonary edema, or fluid overload. 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Ie","year":"2005","journal-title":"J Hum Hypertens"},{"issue":"6","key":"pone.0262519.ref028","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1046\/j.1523-1755.2000.00124.x","article-title":"Analysis of the effect of hemodialysis on peripheral and central arterial pressure waveforms","volume":"57","author":"A Covic","year":"2000","journal-title":"Kidney Int"},{"issue":"8","key":"pone.0262519.ref029","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1093\/ndt\/16.8.1663","article-title":"Acute effects of haemodialysis on endothelial function and large artery elasticity","volume":"16","author":"M Kosch","year":"2001","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association\u2014European Renal Association"},{"issue":"3","key":"pone.0262519.ref030","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/01.HYP.3.3.333","article-title":"Blood pressure response to 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