{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:49:55Z","timestamp":1790660995364,"version":"4.1.0"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    To evaluate the effects of the discontinuation of antithrombotic drugs on intraocular pressure (IOP) reduction and complications from\n                    <jats:italic>ab interno<\/jats:italic>\n                    trabeculotomy for patients with glaucoma. We performed a retrospective chart review on the data of patients treated with antithrombotic agents who have undergone\n                    <jats:italic>ab interno<\/jats:italic>\n                    trabeculotomy through Tanito microhook combined with cataract surgery at the Asahi General Hospital and the Tokyo University Hospital, with 6 months of follow-up. The patients were classified into two groups depending on whether they discontinued (AT-) or continued (AT+) antithrombotic therapy during the perioperative phase. The demographics, pre- and postoperative IOP, medication score, best-corrected visual acuity (BCVA), and postoperative complications were analyzed preoperatively and postoperatively at 1 week and 1\u20136 months. The series included 44 eyes from 44 Japanese patients. The AT- and AT+ groups included 21 eyes from 21 patients and 23 eyes from 23 patients, respectively. The decrease in IOP from the baseline at 1 week postoperative was significantly different between the two groups (p = 0.009), but there were no significant differences observed in the other visits. Hyphema and IOP spikes exceeding 30 mmHg occurred in 10% and 10% of AT- participants, and in 43% and 26% of AT+ participants, respectively. Hyphema and spikes with hyphema occurred more frequently in the AT+ than in the AT- group (p = 0.02 and p = 0.05). The number of patients who had spikes was not significantly different (p = 0.27). In trabeculotomy using the Tanito microhook\u00ae, discontinuing antithrombotic therapy had better IOP-lowering effects and less postoperative complications.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0262548","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T14:20:35Z","timestamp":1642083635000},"page":"e0262548","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effects of antithrombotic therapy in ab interno trabeculotomy with a spatula-shaped microhook"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-8532","authenticated-orcid":true,"given":"Satoru","family":"Kanda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Fujishiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Omoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Aihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"pone.0262548.ref001","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10384-020-00750-3","article-title":"Comparison of the short\u2011term effectiveness and safety profile of ab interno combined trabeculotomy using 2 types of trabecular hooks","volume":"64","author":"T Omoto","year":"2020","journal-title":"Jpn J Ophthalmol"},{"key":"pone.0262548.ref002","article-title":"Comparison of 12\u2011month surgical outcomes of ab interno trabeculotomy with phacoemulsification between spatula\u2011shaped and dual\u2011blade microhooks","author":"T Omoto","year":"2021","journal-title":"Jpn J Ophthalmol"},{"key":"pone.0262548.ref003","article-title":"Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma","author":"T Omoto","year":"2021","journal-title":"PLOS ONE"},{"key":"pone.0262548.ref004","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s10384-019-00682-7","article-title":"Twelve-month efficacy and safety of glaucoma filtration device for surgery in patients with normal-tension glaucoma","volume":"63","author":"M Aihara","year":"2019","journal-title":"Jpn J Ophthalmol"},{"issue":"6","key":"pone.0262548.ref005","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.ajo.2010.11.028","article-title":"Japanese steroid-induced Glaucoma multicenter study group. 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