{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:59:16Z","timestamp":1788829156788,"version":"build-2803163510"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Backgrounds and aims<\/jats:title>\n<jats:p>Inflammatory bowel disease (IBD) patients often experience disease flare-ups during international air travel. We aimed to identify risk factors associated with IBD flare-up during international air travel.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Patients with scheduled international air travel were enrolled in the study from the Seoul National University Bundang Hospital IBD clinic. Flight information and clinical data were collected via questionnaires and personal interviews, and risk factors associated with IBD flares were determined.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Between May 2018 and February 2020, 94 patients were prospectively enrolled in the study (mean age, 33.0 years; males, 53.2%; mean disease duration, 56.7 months), including 56 (59.6%) with ulcerative colitis and 38 (40.4%) with Crohn\u2019s disease. Of the 94 patients enrolled, 15 (16.0%) experienced an IBD flare-up and 79 (84.0%) remained in remission throughout travel. Logistic regression analysis revealed that high fecal calprotectin levels before travel (odds ratio [OR]: 1.001, 95% confidence interval [CI]: 1.000\u20131.001, <jats:italic>p<\/jats:italic> = 0.016), the presence of a comorbidity (OR: 6.334, 95% CI: 1.129\u201335.526, <jats:italic>p<\/jats:italic> = 0.036), and history of emergency room visit (OR: 5.283, 95% CI: 1.085\u201325.724, <jats:italic>p<\/jats:italic> = 0.039) were positively associated with disease flare-up. The previous and current use of immunomodulators and biologics, time of flight, altitude, number countries visited, travel duration, objective of visit, and previous medical consultations were not associated with disease flare-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Elevated fecal calprotectin levels, history of emergency room visits, and the presence of a comorbidity predicted IBD flare-up during international air travel.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0262571","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T18:51:57Z","timestamp":1642791117000},"page":"e0262571","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical factors to predict flare-up in patients with inflammatory bowel disease during international air travel: A prospective study"],"prefix":"10.1371","volume":"17","author":[{"given":"Jihye","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2657-0349","authenticated-orcid":true,"given":"Hyuk","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Min","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"issue":"10114","key":"pone.0262571.ref001","first-page":"2769","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"SC Ng","year":"2018","journal-title":"Lancet"},{"issue":"10080","key":"pone.0262571.ref002","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis.","volume":"389","author":"R Ungaro","year":"2017","journal-title":"Lancet"},{"issue":"10080","key":"pone.0262571.ref003","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s disease.","volume":"389","author":"J Torres","year":"2017","journal-title":"Lancet"},{"issue":"4","key":"pone.0262571.ref004","doi-asserted-by":"crossref","first-page":"379","DOI":"10.5217\/ir.2019.09148","article-title":"Fibrostenotic strictures in Crohn\u2019s disease.","volume":"18","author":"JH Yoo","year":"2020","journal-title":"Intest Res."},{"issue":"5","key":"pone.0262571.ref005","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrgastro.2016.208","article-title":"Current and emerging therapeutic targets for IBD.","volume":"14","author":"MF Neurath","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"pone.0262571.ref006","doi-asserted-by":"crossref","first-page":"347","DOI":"10.5217\/ir.2020.00032","article-title":"Clinical management for small bowel of Crohn\u2019s disease in the treat-to-target era: now is the time to optimize treatment based on the dominant lesion","volume":"18","author":"K. 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