{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:12:26Z","timestamp":1788541946727,"version":"build-2803163510"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Perinatal asphyxia continues to be a significant clinical concern around the world as the consequences can be devastating. World Health Organization data indicates perinatal asphyxia is encountered amongst 6\u201310 newborns per 1000 live full-term birth, and the figures are higher for low and middle-income countries. Nevertheless, studies on the prevalence of asphyxia and the extent of the problem in poorly resourced southern Ethiopian regions are limited. This study aimed to determine the magnitude of perinatal asphyxia and its associated factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A retrospective cross-sectional study design was used from March to April 2020. Data was collected from charts of neonates who were admitted to NICU from January 2016 to December 31, 2019.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Result<\/jats:title>\n<jats:p>The review of 311 neonates\u2019 medical records revealed that 41.2% of the neonates experienced perinatal asphyxia. Preeclampsia during pregnancy (AOR = 6.2, 95%CI:3.1\u201312.3), antepartum hemorrhage (AOR = 4.5, 95%CI:2.3\u20138.6), gestational diabetes mellitus (AOR = 4.2, 95%CI:1.9\u20139.2), premature rupture of membrane (AOR = 2.5, 95%CI:1.33\u20134.7) fetal distress (AOR = 3,95%CI:1.3\u20137.0) and meconium-stained amniotic fluid (AOR = 7.7, 95%CI: 3.1\u201319.3) were the associated factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Substantial percentages of neonates encounter perinatal asphyxia, causing significant morbidity and mortality. Focus on early identification and timely treatment of perinatal asphyxia in hospitals should, therefore, be given priority.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0262619","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T18:48:49Z","timestamp":1642099729000},"page":"e0262619","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Perinatal asphyxia and associated factors among neonates admitted to a specialized public hospital in South Central Ethiopia: A retrospective cross-sectional study"],"prefix":"10.1371","volume":"17","author":[{"given":"Seifu Awgchew","family":"Mamo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girum Sebsibie","family":"Teshome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tewodros","family":"Tesfaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-4169","authenticated-orcid":true,"given":"Abel Tibebu","family":"Goshu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"pone.0262619.ref001","unstructured":"WHO. MCEE-WHO methods and data sources for child causes of death 2000\u20132016. Geneva, Switzerland 2018."},{"key":"pone.0262619.ref002","first-page":"37","volume-title":"Towards a global action plan for healthy lives and well-being for all","author":"WHO","year":"2018"},{"issue":"6","key":"pone.0262619.ref003","doi-asserted-by":"crossref","first-page":"e710","DOI":"10.1016\/S2214-109X(19)30163-9","article-title":"National, regional, and global levels and trends in neonatal mortality between 1990 and 2017, with scenario-based projections to 2030: a systematic analysis","volume":"7","author":"L Hug","year":"2019","journal-title":"The Lancet Global Health"},{"issue":"1","key":"pone.0262619.ref004","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2471\/BLT.14.139790","article-title":"Neonatal cause-of-death estimates for the early and late neonatal periods for 194 countries: 2000\u20132013","volume":"93","author":"S Oza","year":"2015","journal-title":"Bull World Health Organ"},{"issue":"3","key":"pone.0262619.ref005","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.clp.2016.04.004","article-title":"Stillbirths: The Hidden Birth Asphyxia\u2014US and Global Perspectives","volume":"43","author":"RL Goldenberg","year":"2016","journal-title":"Clin Perinatol"},{"key":"pone.0262619.ref006","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12884-015-0472-9","article-title":"Causes of perinatal mortality and associated maternal complications in a South African province: challenges in predicting poor outcomes","volume":"15","author":"ER Allanson","year":"2015","journal-title":"BMC pregnancy and childbirth"},{"issue":"1","key":"pone.0262619.ref007","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12887-017-0876-y","article-title":"Prevalence, severity and early outcomes of hypoxic ischemic encephalopathy among newborns at a tertiary hospital, in northern Tanzania","volume":"17","author":"IN Simiyu","year":"2017","journal-title":"BMC pediatrics"},{"issue":"1","key":"pone.0262619.ref008","doi-asserted-by":"crossref","DOI":"10.5334\/aogh.2541","article-title":"Newborn Mortality in Sub-Saharan Africa: Why is Perinatal Asphyxia Still a Major Cause?","volume":"85","author":"F Usman","year":"2019","journal-title":"Annals of global health"},{"issue":"4","key":"pone.0262619.ref009","doi-asserted-by":"crossref","first-page":"e03793","DOI":"10.1016\/j.heliyon.2020.e03793","article-title":"Prevalence of perinatal asphyxia in East and Central Africa: systematic review and meta-analysis","volume":"6","author":"Y Workineh","year":"2020","journal-title":"Heliyon"},{"issue":"9","key":"pone.0262619.ref010","doi-asserted-by":"crossref","first-page":"e0203763","DOI":"10.1371\/journal.pone.0203763","article-title":"Determinants of birth asphyxia among live birth newborns in University of Gondar referral hospital, northwest Ethiopia: A case-control study","volume":"13","author":"L Wosenu","year":"2018","journal-title":"PloS one"},{"issue":"1","key":"pone.0262619.ref011","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1186\/s13104-018-3611-3","article-title":"Risk factors of birth asphyxia among newborns in public hospitals of Central Zone, Tigray, Ethiopia 2018","volume":"11","author":"H Tasew","year":"2018","journal-title":"BMC research notes"},{"issue":"12","key":"pone.0262619.ref012","doi-asserted-by":"crossref","first-page":"e0226891","DOI":"10.1371\/journal.pone.0226891","article-title":"Birth asphyxia and its associated factors among newborns in public hospital, northeast Amhara, Ethiopia","volume":"14","author":"A Woday","year":"2019","journal-title":"PloS one"},{"key":"pone.0262619.ref013","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13052-014-0094-2","article-title":"\"Risk factors of birth asphyxia\"","volume":"40","author":"HM Aslam","year":"2014","journal-title":"Ital J Pediatr"},{"issue":"1","key":"pone.0262619.ref014","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12884-018-1667-7","article-title":"Prevalence of hypertensive disorders of pregnancy in Ethiopia: a systemic review and meta-analysis","volume":"18","author":"AK Berhe","year":"2018","journal-title":"BMC pregnancy and childbirth"},{"issue":"14","key":"pone.0262619.ref015","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2147\/JMDH.S269744","article-title":"Risk Factors of Antepartum Hemorrhage Among Mothers Who Gave Birth at Suhul General Hospital, 2016: A Case-Control Study","volume":"2021","author":"B Dibaba","year":"2021","journal-title":"J Multidiscip Healthc"},{"key":"pone.0262619.ref016","volume-title":"The role of the clinical pathological dialogue in problem solving","author":"R PA Antonucci","year":"2014"},{"issue":"4","key":"pone.0262619.ref017","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1467-7687.2006.00499.x","article-title":"Mishkin M Brain and cognitive-behavioural development after asphyxia at term birth","volume":"9","author":"WJ Haan M","year":"2006","journal-title":"Dev Sci"},{"issue":"5","key":"pone.0262619.ref018","doi-asserted-by":"crossref","first-page":"e0232406","DOI":"10.1371\/journal.pone.0232406","article-title":"The pattern of neonatal admissions and mortality at a regional and district hospital in the Upper West Region of Ghana; a cross sectional study","volume":"15","author":"EMA Tette","year":"2020","journal-title":"PloS one"},{"issue":"2","key":"pone.0262619.ref019","first-page":"102","article-title":"Pattern of perinatal mortality in babies delivered at the university of ilorin teaching hospital, ilorin, Nigeria","volume":"31","author":"BM Suleiman","year":"2012","journal-title":"West African journal of medicine"},{"key":"pone.0262619.ref020","first-page":"10","volume-title":"National Strategy for Newborn and Child Survival in Ethiopia","author":"Maternal and Child Health Directorate FMoH","year":"2015"},{"issue":"1","key":"pone.0262619.ref021","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13643-019-1012-x","article-title":"Neonatal mortality in Ethiopia: a protocol for systematic review and meta-analysis","volume":"8","author":"T Tekelab","year":"2019","journal-title":"Systematic Reviews"},{"key":"pone.0262619.ref022","first-page":"11","volume-title":"Ethiopia Mini Demographic and Health Survey","author":"Ethiopian Public Health Institute (EPHI) [Ethiopia] and ICF","year":"2019"},{"key":"pone.0262619.ref023","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1155\/2018\/5351010","article-title":"Prevalence and Associated Factors of Perinatal Asphyxia among Neonates in General Hospitals of Tigray, Ethiopia, 2018","volume":"2018","author":"G Gebreheat","year":"2018","journal-title":"BioMed research international"},{"key":"pone.0262619.ref024","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/PHMT.S196265","article-title":"Prevalence and associated factors of perinatal asphyxia among newborns in Dilla University referral hospital, Southern Ethiopia- 2017","volume":"10","author":"A Alemu","year":"2019","journal-title":"Pediatric Health Med Ther"},{"key":"pone.0262619.ref025","first-page":"100","volume-title":"National Reproductive Health Strategy","author":"FDRE Ministry of Health","year":"2016"},{"key":"pone.0262619.ref026","unstructured":"Silte Zone Health department: 2019\/20 Fiscal Year Annual performance report of Silte Zone health Bureau. SNNPR In.; November, 2021."},{"key":"pone.0262619.ref027","first-page":"137","volume-title":"Neonatal Intensive Care Unit (NICU) Training","author":"Federal Ministry of Health","year":"2014"},{"issue":"4","key":"pone.0262619.ref028","doi-asserted-by":"crossref","DOI":"10.4172\/2090-7214.1000279","article-title":"Prevalence of Birth Asphyxia and Associated Factors among Neonates Delivered in Dilchora Referral Hospital, in Dire Dawa, Eastern Ethiopia","volume":"14","author":"NA Ibrahim","year":"2017","journal-title":"Clinics in Mother and Child Health"},{"issue":"8","key":"pone.0262619.ref029","first-page":"63","article-title":"Incidence, Severity and Early Outcome of Hypoxicischemic Encephalopathy among Newborns Born in a Rural Tertiary Care Centre in Southern India","volume":"5","author":"R VC Selvakumar","year":"2017","journal-title":"International Journal of Scientific Study"},{"issue":"1","key":"pone.0262619.ref030","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/00016340903418751","article-title":"Risk factors for asphyxia associated with substandard care during labor","volume":"89","author":"S Berglund","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"pone.0262619.ref031","first-page":"1","article-title":"Hospital-related, maternal, and fetal risk factors for neonatal asphyxia and moderate or severe hypoxic-ischemic encephalopathy: a retrospective cohort study","author":"S Wood","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"pone.0262619.ref032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1179556517746646","article-title":"Incidence and Predictors of Mortality Among Newborns With Perinatal Asphyxia: A 4-Year Prospective Study of Newborns Delivered in Health Care Facilities in Enugu, South-East Nigeria","volume":"11","author":"U Ekwochi","year":"2017","journal-title":"Clin Med Insights Pediatr"},{"issue":"1","key":"pone.0262619.ref033","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3329\/kyamcj.v8i1.33873","article-title":"Prevalence of Perinatal Asphyxia with Evaluation of Associated Risk Factors in a Rural Tertiary Level Hospital","volume":"8","author":"HS Solayman M","year":"2017","journal-title":"KYAMC Journal"},{"issue":"6","key":"pone.0262619.ref034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15406\/ogij.2017.07.00267","article-title":"Birth Asphyxia among Term Neonates at Korle-Bu Teaching Hospital (KBTH) in Accra","volume":"7","author":"A. Samba","year":"2017","journal-title":"Obstetrics & Gynecology International Journal"},{"issue":"1","key":"pone.0262619.ref035","first-page":"1","article-title":"Proportion and factors associated with low fifth minute Apgar score among singleton newborn babies in Gondar University referral hospital; North West Ethiopia","volume":"17","author":"TW Gudayu","year":"2017","journal-title":"African"},{"issue":"1","key":"pone.0262619.ref036","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1186\/s12884-019-2696-6","article-title":"Prevalence and contributing factors of birth asphyxia among the neonates delivered at Nigist Eleni Mohammed memorial teaching hospital, Southern Ethiopia: a cross-sectional study","volume":"19","author":"RA Abdo","year":"2019","journal-title":"BMC pregnancy and childbirth"},{"issue":"1","key":"pone.0262619.ref037","first-page":"29","article-title":"Prevalence and Risk Factors of Birth Asphyxia among Elderly Gravidarum","volume":"27","author":"A SS Nguanboonmak","year":"2019","journal-title":"Thai Jour of Obst and Gynae"},{"issue":"2","key":"pone.0262619.ref038","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/2384-5147.157421","article-title":"Prevalence and Risk Factors for Perinatal Asphyxia as Seen at a Specialist Hospital in Gusau, Nigeria","volume":"2","author":"B Ilah","year":"2015","journal-title":"Sub-Saharan African Journal of Medicine"},{"key":"pone.0262619.ref039","first-page":"1","volume-title":"Antepartum Haemorrhage Green\u2013top Guideline","author":"Royal College of Obstetricians and Gynaecologists","year":"2011"},{"issue":"3","key":"pone.0262619.ref040","first-page":"1","article-title":"Maternal and perinatal outcome of antepartum hemorrhage at three teaching hospitals in Addis Ababa, Ethiopia","volume":"12","year":"2020","journal-title":"Ethiopian Journal of Reproductive Health"},{"issue":"1","key":"pone.0262619.ref041","first-page":"1","article-title":"Maternal Risk Factors Of Premature Delivery In Dr Soetomo Hospital","volume":"47","author":"MT E Utomo","year":"2011","journal-title":"Folia Medica Indonesiana"},{"issue":"3","key":"pone.0262619.ref042","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.dsx.2019.04.005","article-title":"Barriers for detection and management of gestational diabetes mellitus in southern Ethiopia: A qualitative study","volume":"13","author":"EW Woticha","year":"2019","journal-title":"Diabetes Metab Syndr"},{"key":"pone.0262619.ref043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.midw.2020.102713","article-title":"Gestational diabetes mellitus increased the risk of adverse neonatal outcomes: A prospective cohort study in Northwest Ethiopia","volume":"87","author":"AA Muche","year":"2020","journal-title":"Midwifery"},{"issue":"5","key":"pone.0262619.ref044","first-page":"637","article-title":"Perinatal Factors Leading to Birth Asphyxia among Term Newborns in a Tertiary Care Hospital","volume":"24","author":"KA Kiyani AN","year":"2014","journal-title":"Iran J Pediatr"},{"issue":"1","key":"pone.0262619.ref045","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.apjr.2015.12.014","article-title":"Risk factors and adverse perinatal outcome associated with low birth weight in Northern Tanzania: a registry-based retrospective cohort study","volume":"5","author":"M Mitao","year":"2016","journal-title":"Asian Pacific Journal of Reproduction"},{"issue":"1","key":"pone.0262619.ref046","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2393-4-15","article-title":"\u2019Perinatal outcome in preterm premature rupture of membranes with Amniotic fluid index < 5 (AFI < 5)","volume":"4","author":"S Borna","year":"2004","journal-title":"BMC pregnancy and childbirth"},{"issue":"05","key":"pone.0262619.ref047","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4236\/jbm.2017.55003","article-title":"Associative Factors for Birth Asphyxia at Queen Elizabeth Central Hospital\u2014Malawi","volume":"05","author":"E Tewesa","year":"2017","journal-title":"Journal of Biosciences and Medicines"},{"issue":"2","key":"pone.0262619.ref048","article-title":"Meconium-stained amniotic fluid as a risk factor for perinatal asphyxia","volume":"6","author":"V, E A Mehta","year":"2019","journal-title":"International Journal of Contemporary Pediatrics"},{"key":"pone.0262619.ref049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/4367248","article-title":"Prevalence and Associated Factors of Perinatal Asphyxia in Neonates Admitted to Ayder Comprehensive Specialized Hospital, Northern Ethiopia: A Cross-Sectional Study","volume":"2020","author":"GT Gebregziabher","year":"2020","journal-title":"Int J Pediatr"},{"issue":"17","key":"pone.0262619.ref050","first-page":"1","article-title":"Knowledge and utilization of partograph among obstetric care givers in public health institutions of Addis Ababa, Ethiopia","volume":"13","author":"BD Engida 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