{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:14:39Z","timestamp":1784542479490,"version":"3.55.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU-M104019"],"award-info":[{"award-number":["KMU-M104019"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUH109-M924"],"award-info":[{"award-number":["KMUH109-M924"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>This study compared the recurrence risk of single versus dual adjuvant radiotherapy (RT) and hormonal therapy (HT) following breast-conserving surgery (BCS) in patients with hormone receptor-positive ductal carcinoma in situ (DCIS).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This retrospective cohort study used the Taiwan Cancer Registry database linking to the Taiwan National Health Insurance data from 2011 to 2016. We compared the recurrence risk between BCS-based regimens in Cox regressions and presented as adjusted hazard ratio (HR) and 95% confidence interval (95%CI).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The 1,836 study cohort with a low-to-intermediate risk of recurrence was grouped into BCS alone (6.1%), BCS+RT (6.2%), BCS+HT (23.4%) and BCS+HT+RT (64.3%) according to the initial treatments. During the follow-up (median: 3.3 years), the highest 5-year recurrence-free survival rate was in BCS+RT (94.1%) group and followed by BCS+HT+RT (92.8%), BCS+HT (87.4%) and BCS alone (84.9%). Of the single adjuvant therapies, RT was more effective than HT. Both BCS+HT (HR: 1.52, 95%CI: 0.99\u20132.35) and BCS+RT (HR: 1.10, 95%CI: 0.50\u20132.41) did not significantly increase recurrence risk comparing against the BCS+HT+RT group.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Single adjuvant demonstrated a similar subsequent recurrence risk with dual adjuvant. This study supports the proposition to de-escalate adjuvant treatments in patients with low-to-intermediate risk of DCIS recurrence.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0262934","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T18:33:06Z","timestamp":1643394786000},"page":"e0262934","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigating the effectiveness of adjuvant therapy for patients with hormone receptor-positive ductal carcinoma in situ"],"prefix":"10.1371","volume":"17","author":[{"given":"Chi-Jui","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Yin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Chia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1565-2936","authenticated-orcid":true,"given":"Kun-Pin","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"issue":"8","key":"pone.0262934.ref001","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1023\/A:1008900220924","article-title":"Mammography and breast cancer detection by race and Hispanic ethnicity: results from a national program (United States)","volume":"11","author":"DS May","year":"2000","journal-title":"Cancer Causes Control"},{"issue":"20","key":"pone.0262934.ref002","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1001\/jama.1993.03510200050031","article-title":"Positive predictive value of screening mammography by age and family history of breast cancer","volume":"270","author":"K Kerlikowske","year":"1993","journal-title":"JAMA"},{"issue":"20","key":"pone.0262934.ref003","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1093\/jnci\/94.20.1546","article-title":"Detection of ductal carcinoma in situ in women undergoing screening mammography","volume":"94","author":"VL Ernster","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"pone.0262934.ref004","unstructured":"National Comprehensive Cancer Network. 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