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Other conservative treatments such as neural management techniques may also contribute to sciatica recovery, but currently, the effects have not been robustly assessed. Thus, the aim of this study is to compare the effects of adding neural management to advice to stay active versus advice to stay active alone in improving pain intensity and functional limitation. Secondarily, to compare the effects of the experimental intervention in the sciatic neurodynamic, pain modulation, and psychosocial factors. A parallel-group, controlled, examiner-blinded superiority clinical trial randomised at a 1:1 allocation will be conducted in 210 participants with chronic sciatica. Patients will be recruited from outpatient physiotherapy clinics and community advertisements. The experimental group will receive neural mobilisation techniques and soft tissue mobilisation techniques for 30 minutes per session, 10 weekly sessions, plus advice to stay active on their activities of daily living, information on physical activity, imaging tests, and sciatica for 5 biweekly sessions lasting 25\u201330 minutes. The control group will receive advice to stay active only. The re-evaluation will be performed out after 5 weeks, 10 weeks, and 26 weeks after randomisation and primary endpoints will be pain intensity and functional limitation at 10 weeks. Secondary outcomes will include neuropathic symptoms, sciatic neurodynamic, pain modulation, and psychosocial factors. Adverse events and patient satisfaction will be assessed. Ethical approval has been granted from an Institutional Human Research Ethics Committee.<\/jats:p>\n<jats:p><jats:bold>Trial registration<\/jats:bold>: Trial was prospectively registered in the Brazilian Registry of Clinical Trials (number: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/ensaiosclinicos.gov.br\/rg\/RBR-3db643c\" xlink:type=\"simple\">RBR-3db643c<\/jats:ext-link>).<\/jats:p>","DOI":"10.1371\/journal.pone.0263152","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T18:29:46Z","timestamp":1643999386000},"page":"e0263152","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neural management plus advice to stay active on clinical measures and sciatic neurodynamic for patients with chronic sciatica: Study protocol for a controlled randomised clinical trial"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-7111","authenticated-orcid":true,"given":"Leticia Amaral","family":"Corr\u00eaa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9522-8523","authenticated-orcid":true,"given":"Juliana Valentim","family":"Bittencourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Alice","family":"Mainenti Pagnez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Mathieson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Tirotti","family":"Saragiotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Felicio","family":"Telles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ney","family":"Meziat-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro Alberto","family":"Calazans Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"issue":"10159","key":"pone.0263152.ref001","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 Diseases and Injuries for 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"SL James","year":"2018","journal-title":"Lancet"},{"key":"pone.0263152.ref002","article-title":"Distribution and prevalence of musculoskeletal pain co-occurring with persistent low back pain: a systematic review.","author":"CK \u00d8ver\u00e5s","year":"2021","journal-title":"BMC Musculoskelet Disord"},{"issue":"11","key":"pone.0263152.ref003","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/AJP.0000000000000879","article-title":"Prevalence, Characteristics, and Clinical Course of Neuropathic Pain in Primary Care Patients Consulting with Low Back-related Leg Pain.","volume":"36","author":"SA Harrisson","year":"2020","journal-title":"Clin J Pain"},{"issue":"13","key":"pone.0263152.ref004","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1056\/NEJMra1410151","article-title":"Sciatica","volume":"372","author":"AH Ropper","year":"2015","journal-title":"N Engl J Med"},{"issue":"11","key":"pone.0263152.ref005","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/BRS.0b013e31823a426f","article-title":"Does radiating spinal pain determine future work disability? 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