{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:47:10Z","timestamp":1787942830133,"version":"build-2784847793"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006510","name":"Duke University","doi-asserted-by":"publisher","award":["N\/a - MZR received funding from anonymous donors to support this work"],"award-info":[{"award-number":["N\/a - MZR received funding from anonymous donors to support this work"]}],"id":[{"id":"10.13039\/100006510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Misophonia is a newly described condition characterized by sensory and emotional reactivity (e.g., anxiety, anger, disgust) to repetitive, pattern-based sounds (e.g., throat clearing, chewing, slurping). Individuals with misophonia report significant functional impairment and interpersonal distress. Growing research indicates ineffective coping and emotional functioning broadly (e.g., affective lability, difficulties with emotion regulation) are central to the clinical presentation and severity of misophonia. Preliminary evidence suggests an association between negative emotionality and deficits in emotion regulation in misophonia. Still, little is known about (a) the relationships among specific components of emotional functioning (e.g., emotion regulation, affective lability) with misophonia, and (b) which component(s) of misophonia (e.g., noise frequency, emotional and behavioral responses, impairment) are associated with emotional functioning. Further, despite evidence that mood and anxiety disorders co-occur with misophonia, investigation thus far has not controlled for depression and anxiety symptoms. Examination of these relationships will help inform treatment development for misophonia. The present study begins to disambiguate the relationships among affective lability, difficulties with emotion regulation, and components of misophonia. A sample of 297 participants completed questionnaires assessing misophonia, emotional functioning, depression, anxiety, and COVID-19 impact. Findings indicated that misophonia severity was positively associated with each of these constructs with small to medium effect sizes. When controlling for depression, anxiety, and COVID-19 impact, results from this preliminary study suggest that (a) difficulties with emotion regulation may be correlated with misophonia severity, and (b) misophonic responses, not number of triggers or perceived severity, are associated with difficulties with emotion regulation. Overall, these findings begin to suggest that emotion regulation is important to our understanding the risk factors and treatment targets for misophonia.<\/jats:p>","DOI":"10.1371\/journal.pone.0263230","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T18:24:25Z","timestamp":1644603865000},"page":"e0263230","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":63,"title":["Examining emotional functioning in misophonia: The role of affective instability and difficulties with emotion regulation"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-9917","authenticated-orcid":true,"given":"Rachel E.","family":"Guetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clair","family":"Cassiello-Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Trumbull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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Wu","year":"2014","journal-title":"Journal of Clinical Psychology"},{"key":"pone.0263230.ref007","article-title":"Development and psychometric exploration of a semi-structured clinical interview for Misophonia","volume":"187","author":"R. E. Guetta","year":"2021","journal-title":"Personality and Individual Differences"},{"issue":"1","key":"pone.0263230.ref008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4092\/jsre.2.1","article-title":"A functionalist perspective on the nature of emotion","volume":"2","author":"J. J. Campos","year":"1994","journal-title":"Japanese Journal of Research on Emotions"},{"issue":"2","key":"pone.0263230.ref009","first-page":"151","article-title":"Emotion regulation and mental health. Clinical Psychology","volume":"2","author":"J. J. Gross","year":"1995","journal-title":"Science and Practice"},{"key":"pone.0263230.ref010","article-title":"Incorporating emotion regulation into conceptualizations and treatments of anxiety and mood disorders","volume":"2","author":"L. Campbell-Sills","year":"2007","journal-title":"Handbook of Emotion Regulation"},{"issue":"6","key":"pone.0263230.ref011","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1037\/0022-006X.64.6.1152","article-title":"Experiential avoidance and behavioral disorders: A functional dimensional approach to diagnosis and treatment","volume":"64","author":"S. C. Hayes","year":"1996","journal-title":"Journal of Consulting and Clinical Psychology"},{"issue":"2","key":"pone.0263230.ref012","first-page":"118","article-title":"The case for borderline personality disorder as an emotional disorder: Implications for treatment. Clinical Psychology","volume":"21","author":"S. Sauer\u2010Zavala","year":"2014","journal-title":"Science and Practice"},{"key":"pone.0263230.ref013","article-title":"The mediating role of emotion regulation within the relationship between neuroticism and misophonia: A preliminary investigation","author":"C. Cassiello-Robbins","year":"2020","journal-title":"Frontiers in Psychology, section Psychopathology"},{"issue":"1","key":"pone.0263230.ref014","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cbpra.2018.04.003","article-title":"The suitability of an inhibitory learning approach in exposure when habituation fails: A clinical application to misophonia","volume":"26","author":"B. Frank","year":"2019","journal-title":"Cognitive and Behavioral Practice"},{"issue":"4","key":"pone.0263230.ref015","doi-asserted-by":"crossref","first-page":"e0231390","DOI":"10.1371\/journal.pone.0231390","article-title":"Misophonia: Phenomenology, comorbidity and demographics in a large sample","volume":"15","author":"I. 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Lewin","year":"2021","journal-title":"Journal of Affective Disorders"},{"key":"pone.0263230.ref019","article-title":"Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey","volume":"112954","author":"Y. Huang","year":"2020","journal-title":"Psychiatry Research"},{"key":"pone.0263230.ref020","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev-clinpsy-021815-093623","article-title":"Conducting clinical research using crowdsourced convenience samples","volume":"12","author":"J. Chandler","year":"2016","journal-title":"Annual Review of Clinical Psychology"},{"issue":"3","key":"pone.0263230.ref021","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10862-015-9529-3","article-title":"The Difficulties in Emotion Regulation Scale Short Form (DERS-SF): Validation and replication in adolescent and adult samples","volume":"38","author":"E. A. 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Kazak","year":"2020"},{"key":"pone.0263230.ref027","unstructured":"IBM SPSS Statistics for Windows (2019), Version 26 (IBM Corp., Armonk, N.Y., USA)."},{"key":"pone.0263230.ref028","volume-title":"Essentials of statistics for the behavioral sciences","author":"F. Gravetter","year":"2014","edition":"8"},{"key":"pone.0263230.ref029","volume-title":"The research methods knowledge base","author":"W. Trochim","year":"2006","edition":"3"},{"issue":"15","key":"pone.0263230.ref030","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.3390\/ijerph17155464","article-title":"Prevalence of Misophonia and Correlates of Its Symptoms among Inpatients with Depression","volume":"17","author":"M. 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Sakiris","year":"2019","journal-title":"Clinical Psychology Review"},{"key":"pone.0263230.ref034","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jad.2017.04.017","article-title":"Cognitive behavioral therapy is effective in misophonia: An open trial","volume":"217","author":"A. E. Schr\u00f6der","year":"2017","journal-title":"Journal of Affective Disorders"},{"issue":"6","key":"pone.0263230.ref035","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0092-6566(03)00046-1","article-title":"A very brief measure of the Big-Five personality domains","volume":"37","author":"S. D. Gosling","year":"2003","journal-title":"Journal of Research in personality"},{"issue":"3","key":"pone.0263230.ref036","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/bdm.1753","article-title":"Data collection in a flat world: Accelerating consumer behavior research by using Mechanical Turk","volume":"26","author":"J. K. 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