{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:01:38Z","timestamp":1787022098766,"version":"build-2736575974"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Stichting Q-support","award":["AMPHI150114-00"],"award-info":[{"award-number":["AMPHI150114-00"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This study aimed to determine short- and long-term physical and psychosocial impact of\n                      <jats:italic>Coxiella burnetii<\/jats:italic>\n                      infection in three distinct entities: Q-fever fatigue syndrome (QFS), chronic Q-fever, and patients with past acute Q-fever without QFS or chronic Q-fever.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Integrative data analysis was performed, combining original data from eight studies measuring quality of life (QoL), fatigue, physical and social functioning with identical validated questionnaires, from three months to eight years after onset infection. Linear trends in each outcome were compared between Q-fever groups using multilevel linear regression analyses to account for repeated measures within patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data included 3947 observations of 2313 individual patients (228 QFS, 135 chronic Q-fever and 1950 patients with past acute Q-fever). In the first years following infection, physical and psychosocial impact was highest among QFS patients, and remained high without significant improvements over time. In chronic Q-fever patients, QoL and physical functioning worsened significantly over time. Levels of fatigue and social participation in patients with past acute Q-fever improved significantly over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The impact differs greatly between the three Q-fever groups. It is important that physicians are aware of these differences, in order to provide relevant care for each patient group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0263239","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T13:31:05Z","timestamp":1643808665000},"page":"e0263239","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Q-fever on physical and psychosocial functioning until 8 years after Coxiella burnetii infection: An integrative data analysis"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3324-6993","authenticated-orcid":true,"given":"Daphne F. M.","family":"Reukers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4269-0041","authenticated-orcid":true,"given":"Cornelia H. 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Aanhoudende vermoeidheid na een Q-koortsinfectie","volume":"156","author":"SP Keijmel","year":"2012","journal-title":"Ned Tijdsch Geneesk"},{"issue":"5","key":"pone.0263239.ref004","doi-asserted-by":"crossref","first-page":"e0155884","DOI":"10.1371\/journal.pone.0155884","article-title":"Fatigue following Acute Q-Fever: A Systematic Literature Review","volume":"11","author":"G Morroy","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"pone.0263239.ref005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0950268810002268","article-title":"The Q fever epidemic in The Netherlands: history, onset, response and reflection","volume":"139","author":"HI Roest","year":"2011","journal-title":"Epidemiology & Infection"},{"key":"pone.0263239.ref006","unstructured":"National Institute for Public Health and the Environment (RIVM). [Home \/ Topics \/ Q \/ Q fever] Home \/ Onderwerpen \/ Q \/ Q-koorts [August 2019]. https:\/\/www.rivm.nl\/Onderwerpen\/Q\/Q_koorts."},{"key":"pone.0263239.ref007","unstructured":"Reukers D, van Asten L, Brandsema P, Dijkstra F, Hendriksen J, van der Hoek W, et al. Annual report Surveillance of influenza and other respiratory infections in the Netherlands: winter 2019\/2020. Surveillance van griep en andere luchtweginfecties: winter 2019\/2020: Rijksinstituut voor Volksgezondheid en Milieu RIVM; 2021."},{"issue":"2","key":"pone.0263239.ref008","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/qjmed\/91.2.105","article-title":"Post-infection fatigue syndrome following Q fever","volume":"91","author":"JG Ayres","year":"1998","journal-title":"QJM: monthly journal of the Association of Physicians"},{"issue":"8","key":"pone.0263239.ref009","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/qjmed\/95.8.527","article-title":"Chronic fatigue following infection by Coxiella burnetii (Q fever): ten-year follow-up of the 1989 UK outbreak cohort","volume":"95","author":"MJ Wildman","year":"2002","journal-title":"QJM: monthly journal of the Association of Physicians"},{"issue":"9006","key":"pone.0263239.ref010","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0140-6736(96)91469-5","article-title":"Protracted debility and fatigue after acute Q fever","volume":"347","author":"BP Marmion","year":"1996","journal-title":"Lancet"},{"issue":"1","key":"pone.0263239.ref011","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1017\/S0950268814000417","article-title":"A cross-sectional study to assess the long-term health status of patients with lower respiratory tract infections, including Q fever","volume":"143","author":"AS van Dam","year":"2015","journal-title":"Epidemiology and infection"},{"issue":"3","key":"pone.0263239.ref012","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jinf.2014.10.010","article-title":"Q-fever patients suffer from impaired health status long after the acute phase of the illness: results from a 24-month cohort study","volume":"70","author":"JA van Loenhout","year":"2015","journal-title":"J Infect"},{"issue":"6","key":"pone.0263239.ref013","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jinf.2014.01.004","article-title":"Serious long-term health consequences of Q-fever and Legionnaires\u2019 disease","volume":"68","author":"JA van Loenhout","year":"2014","journal-title":"Journal of Infection"},{"issue":"12","key":"pone.0263239.ref014","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1017\/S0950268814003689","article-title":"Severely impaired health status of non-notified Q fever patients leads to an underestimation of the true burden of disease","volume":"143","author":"JAF van Loenhout","year":"2015","journal-title":"Epidemiology & Infection"},{"key":"pone.0263239.ref015","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1471-2334-11-97","article-title":"The health status of Q-fever patients after long-term follow-up","volume":"11","author":"G Morroy","year":"2011","journal-title":"BMC Infect Dis"},{"issue":"12","key":"pone.0263239.ref016","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/qjmed\/hcq144","article-title":"Detailed analysis of health status of Q fever patients 1 year after the first Dutch outbreak: a case-control study. 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[Multidisciplinary guideline Q-fever Fatigue Syndrome (QFS) revised July 2019] Multidisciplinaire LCI-richtlijn Q-koortsvermoeidheidssyndroom (QVS) Herziene versie juli 2019 2019 [November 2019]. https:\/\/lci.rivm.nl\/sites\/default\/files\/2019-07\/Multidisciplinaire%20LCI-richtlijn%20QVS.pdf."},{"issue":"5","key":"pone.0263239.ref025","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1128\/JCM.03221-13","article-title":"Chronic Q fever in the Netherlands 5 years after the start of the Q fever epidemic: results from the Dutch chronic Q fever database","volume":"52","author":"LM Kampschreur","year":"2014","journal-title":"J Clin Microbiol"},{"key":"pone.0263239.ref026","first-page":"131","article-title":"De Checklist Individual Strength (CIS)","volume":"32","author":"JH Vercoulen","year":"1999","journal-title":"Gedragstherapie"},{"issue":"5","key":"pone.0263239.ref027","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0022-3999(94)90099-X","article-title":"Dimensional assessment of chronic fatigue syndrome","volume":"38","author":"JH Vercoulen","year":"1994","journal-title":"Journal of psychosomatic research"},{"issue":"8","key":"pone.0263239.ref028","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0005-7967(97)00025-9","article-title":"Screening for major depression disorders in medical inpatients with the Beck Depression Inventory for Primary Care","volume":"35","author":"AT Beck","year":"1997","journal-title":"Behav Res Ther"},{"issue":"1","key":"pone.0263239.ref029","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1207\/s15327752jpa4901_13","article-title":"The Satisfaction With Life Scale","volume":"49","author":"E Diener","year":"1985","journal-title":"Journal of Personality Assessment"},{"issue":"8","key":"pone.0263239.ref030","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/00005650-198108000-00001","article-title":"The Sickness Impact Profile: development and final revision of a health status measure","volume":"19","author":"M Bergner","year":"1981","journal-title":"Med Care"},{"key":"pone.0263239.ref031","first-page":"1950","article-title":"De \u2019sickness impact profile\u2019; resultaten van een valideringsonderzoek van de Nederlandse versie","volume":"134","author":"HM Jacobs","year":"1990","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"4 Suppl","key":"pone.0263239.ref032","first-page":"AS264","article-title":"Comparison of methods for the scoring and statistical analysis of SF-36 health profile and summary measures: summary of results from the Medical Outcomes Study","volume":"33","author":"JE Ware","year":"1995","journal-title":"Med Care"},{"issue":"7","key":"pone.0263239.ref033","doi-asserted-by":"crossref","first-page":"e0131848","DOI":"10.1371\/journal.pone.0131848","article-title":"Long-Term Serological Follow-Up of Acute Q-Fever Patients after a Large Epidemic","volume":"10","author":"CCH Wielders","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"pone.0263239.ref034","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/occmed\/kqi013","article-title":"A systematic review describing the prognosis of chronic fatigue syndrome","volume":"55","author":"R Cairns","year":"2005","journal-title":"Occup Med (Lond)"},{"issue":"11","key":"pone.0263239.ref035","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.cmi.2018.11.023","article-title":"Chronic Q fever-related complications and mortality: data from a nationwide cohort","volume":"25","author":"SE van Roeden","year":"2019","journal-title":"Clin Microbiol Infect"},{"issue":"11","key":"pone.0263239.ref036","first-page":"791","article-title":"Chronic Q fever: patient and treatment-related factors influencing long-term quality of life. 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