{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:06:29Z","timestamp":1788444389847,"version":"build-2803163510"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI068633"],"award-info":[{"award-number":["UM1AI068633"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI068615"],"award-info":[{"award-number":["UM1AI068615"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI106707"],"award-info":[{"award-number":["UM1AI106707"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Conrad","award":["AID-OAA-A-14-00010"],"award-info":[{"award-number":["AID-OAA-A-14-00010"]}]},{"name":"CONRAD","award":["AID-OAA-A-14-00011"],"award-info":[{"award-number":["AID-OAA-A-14-00011"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Given challenges with adherence to existing HIV prevention products, the development of an extended duration vaginal ring could improve adherence while reducing patient and provider burden. Additionally, women have other interlinked sexual health concerns such as unintended pregnancy. We evaluated acceptability of a 90-day ring to prevent HIV and hypothetical preferences for a dual (HIV and contraceptive) indication. This was a secondary analysis of a Phase 1, two-arm, multi-site, placebo-controlled randomized trial evaluating safety and pharmacokinetics of a 90-day vaginal ring containing tenofovir for HIV prevention (N = 49). We used a mixed methods approach to assess quantitative data on acceptability (n = 49) and used qualitative data from a random subset to explain the quantitative findings (N = 25). The 3-month extended duration tenofovir ring was highly acceptable. Participants perceived the ring to be easy to use, comfortable and reported liking it more over time. About half felt the ring during sex but most of those participants said it bothered them only a little. Concerns about hygiene increased over the study period but were often outweighed by the benefits of an extended duration ring. Interest in a multi-purpose ring was high (77%) and even higher among those who were sexually active and had male partners. The 3-month extended duration tenofovir ring for HIV prevention was highly acceptable among women and interest in an MPT was high.<\/jats:p>","DOI":"10.1371\/journal.pone.0263664","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T18:37:41Z","timestamp":1645555061000},"page":"e0263664","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Acceptability of an extended duration vaginal ring for HIV prevention and interest in a multi-purpose ring"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-8669","authenticated-orcid":true,"given":"Marie C. 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Available: http:\/\/aidsinfo.unaids.org\/"},{"key":"pone.0263664.ref002","unstructured":"Rees H, Delany-Moretlwe S, Lombard C, Baron D, Panchia R, Myer L, et al. FACTS 001 Phase III Trial of Pericoital Tenofovir 1% Gel for HIV Prevention in Women. Conference on Retroviruses and Opportunistic Infections (CROI). 2015."},{"key":"pone.0263664.ref003","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1056\/NEJMoa1402269","article-title":"Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women","volume":"372","author":"JM Marrazzo","year":"2015","journal-title":"N Engl J Med"},{"key":"pone.0263664.ref004","article-title":"Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women","author":"QA Karim","year":"2010","journal-title":"Science (80-)"},{"key":"pone.0263664.ref005","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1097\/QAD.0000000000001145","article-title":"Effectiveness and safety of oral HIV preexposure prophylaxis for all populations","volume":"30","author":"VA Fonner","year":"2016","journal-title":"AIDS"},{"key":"pone.0263664.ref006","article-title":"HIV pre-exposure prophylaxis for adolescent girls and young women in Africa: from efficacy trials to delivery","author":"CL Celum","year":"2019","journal-title":"Journal of the International AIDS Society"},{"key":"pone.0263664.ref007","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1202614","article-title":"Preexposure prophylaxis for HIV infection among African women","volume":"367","author":"L Van Damme","year":"2012","journal-title":"N Engl J Med"},{"key":"pone.0263664.ref008","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa1506110","article-title":"Use of a vaginal ring containing dapivirine for HIV-1 prevention in women","volume":"375","author":"JM Baeten","year":"2016","journal-title":"N Engl J Med"},{"key":"pone.0263664.ref009","article-title":"Safety and efficacy of a dapivirine vaginal ring for HIV prevention in women","author":"A Nel","year":"2016","journal-title":"N Engl J Med"},{"key":"pone.0263664.ref010","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1097\/00002030-200108004-00011","article-title":"The epidemiology of HSV-2 infection and its association with HIV infection in four urban African populations","author":"H a Weiss","year":"2001","journal-title":"AIDS (London, England)"},{"key":"pone.0263664.ref011","first-page":"299","article-title":"Herpes simplex virus type 2: epidemiology and management options in developing countries","volume":"84","author":"G Paz-Bailey","year":"2008","journal-title":"Postgrad Med J"},{"key":"pone.0263664.ref012","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01.aids.0000198081.09337.a7","article-title":"Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies","volume":"20","author":"EE Freeman","year":"2006","journal-title":"AIDS"},{"key":"pone.0263664.ref013","unstructured":"MTN 038. 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