{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:38:11Z","timestamp":1778596691561,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["UM.C\/HIR\/MOHE\/06"],"award-info":[{"award-number":["UM.C\/HIR\/MOHE\/06"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yayasan PETRONAS"},{"DOI":"10.13039\/100019524","name":"Yayasan Sime Darby","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019524","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>There is an increasing number of cancer patients undertaking treatment-focused genetic testing despite not having a strong family history or high <jats:italic>a priori<\/jats:italic> risk of being carriers because of the decreasing cost of genetic testing and development of new therapies. There are limited studies on the psychosocial outcome of a positive result among breast cancer patients who are at low <jats:italic>a priori<\/jats:italic> risk, particularly in women of Asian descent. Breast cancer patients enrolled under the Malaysian Breast Cancer Genetic Study between October 2002 and February 2018 were tested for <jats:italic>BRCA1<\/jats:italic>, <jats:italic>BRCA2<\/jats:italic> and <jats:italic>PALB2<\/jats:italic> genes. All 104 carriers identified were invited by a research genetic counsellor for result disclosure. Of the 104 carriers, 64% (N = 66) had low <jats:italic>a priori<\/jats:italic> risk as determined by PENN II scores. Psychosocial, risk perception and health behaviour measures survey were conducted at baseline (pre-result disclosure), and at two to six weeks after result disclosure. At baseline, younger carriers with high <jats:italic>a priori<\/jats:italic> risk had higher Cancer Worry Scale scores than those with low <jats:italic>a priori<\/jats:italic> risk but all scores were within acceptable range. Around 75% and 55% of high <jats:italic>a priori<\/jats:italic> risk carriers as well as 80% and 67% of low <jats:italic>a priori<\/jats:italic> risk carriers had problems in the \u201cliving with cancer\u201d and \u201cchildren\u201d psychosocial domains respectively. All carriers regardless of their <jats:italic>a priori<\/jats:italic> risk demonstrated an improved risk perception that also positively influenced their intent to undergo risk management procedures. This study has shown that with sufficient counselling and support, low <jats:italic>a priori risk<\/jats:italic> carriers are able to cope psychologically, have improved perceived risk and increased intent for positive health behaviour despite having less anticipation from a family history prior to knowing their germline carrier status.<\/jats:p>","DOI":"10.1371\/journal.pone.0263675","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T18:27:09Z","timestamp":1644949629000},"page":"e0263675","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Psychosocial outcome and health behaviour intent of breast cancer patients with BRCA1\/2 and PALB2 pathogenic variants unselected by a priori risk"],"prefix":"10.1371","volume":"17","author":[{"given":"Heamanthaa","family":"Padmanabhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur Tiara","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siu-Wan","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Quan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siti 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