{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:07:25Z","timestamp":1790647645553,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>To date, literature has depicted an increase in mortality among patients with hip fractures, directly related to acute coronavirus disease 2019 (COVID-19) infection and not due to underlying comorbidities. Usual orthogeriatric pathway in our Department was disrupted during the pandemic. This study aimed to evaluate early mortality within 30 days, in 2019 and 2020 in our Level 1 trauma-center. We compared two groups of patients aged &gt;60 years, with osteoporotic upper hip fractures, in February\/March\/April 2020 and February\/March\/April 2019, in our level 1 trauma center. A total of 102 and 79 patients met the eligibility criteria in 2019 and 2020, respectively. Mortality was evaluated, merging our database with the French open database for death from the INSEE, which is prospectively updated each month. Causes of death were recorded. Charlson Comorbidity Index was evaluated for comorbidities, Instrumental Activity of Daily Living (IADL), and Activity of Daily Living (ADL) scores were assessed for autonomy. There were no differences in age, sex, fracture type, Charlson Comorbidity Index, IADL, and ADL. 19 patients developed COVID-19 infection. The 30-day survival was 97% (95% CI, 94%\u2013100%) in 2019 and 86% (95% CI, 79%\u201394%) in 2020 (HR = 5, 95%CI, 1.4\u201318.2, p = 0.013). In multivariable Cox\u2019PH model, the period (2019\/2020) was significantly associated to the 30-day mortality (HR = 6.4, 95%CI, 1.7\u201323, p = 0.005) and 6-month mortality (HR = 3.4, 95%CI, 1.2\u20139.2, p = 0.01). COVID infection did not modify significantly the 30-day and 6-month mortality. This series brought new important information, early mortality significantly increased because of underlying disease decompensation. Minimal comprehensive care should be maintained in all circumstances in order to avoid excess of mortality among elderly population with hip fractures.<\/jats:p>","DOI":"10.1371\/journal.pone.0263680","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T18:36:16Z","timestamp":1645814176000},"page":"e0263680","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Excess mortality after hip fracture during COVID-19 pandemic: More about disruption, less about virulence\u2014Lesson from a trauma center"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7361-8392","authenticated-orcid":true,"given":"Baptiste","family":"Boukebous","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Maillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e8le","family":"Neouze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Esnault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Biau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Antoine","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"pone.0263680.ref001","doi-asserted-by":"crossref","first-page":"e0206926","DOI":"10.1371\/journal.pone.0206926","article-title":"Transmissibility of emerging viral zoonoses","volume":"13","author":"JW Walker","year":"2018","journal-title":"PLOS ONE"},{"key":"pone.0263680.ref002","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.micinf.2018.06.001","article-title":"Zoonoses under our noses","volume":"21","author":"AR Cross","year":"2019","journal-title":"Microbes Infect"},{"key":"pone.0263680.ref003","doi-asserted-by":"crossref","first-page":"e0246956","DOI":"10.1371\/journal.pone.0246956","article-title":"Impact of the COVID-19 shutdown on orthopedic trauma numbers and patterns in an academic Level I Trauma Center in Berlin, Germany","volume":"16","author":"T Maleitzke","year":"2021","journal-title":"PLoS One"},{"key":"pone.0263680.ref004","article-title":"Epidemiologic characteristics of traumatic fractures in elderly patients during the outbreak of coronavirus disease 2019 in China","author":"Y Zhu","year":"2020","journal-title":"Int Orthop"},{"key":"pone.0263680.ref005","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.injury.2020.05.016","article-title":"Impact of the COVID-19 Pandemic on an Emergency Traumatology Service: Experience at a Tertiary Trauma Centre in Spain","volume":"51","author":"JH Nu\u00f1ez","year":"2020","journal-title":"Injury"},{"key":"pone.0263680.ref006","first-page":"1","article-title":"Impact of the COVID-19 pandemic on orthopedic trauma workload in a London level 1 trauma center: the \u201cgolden month.\u201d","author":"C Park","year":"2020","journal-title":"Acta Orthop"},{"key":"pone.0263680.ref007","first-page":"1","article-title":"IMPACT-Restart: the influence of COVID-19 on postoperative mortality and risk factors associated with SARS-CoV-2 infection after orthopaedic and trauma surgery","author":"ND Clement","year":"2020","journal-title":"The Bone & Joint Journal"},{"key":"pone.0263680.ref008","first-page":"297","article-title":"Association of New Coronavirus Disease with Fragility Hip and Lower Limb Fractures in Elderly Patients.","volume":"8","author":"MJ Shariyate","year":"2020","journal-title":"Arch Bone Jt Surg"},{"key":"pone.0263680.ref009","article-title":"Increased Mortality and Major Complications in Hip Fracture Care During the COVID-19 Pandemic: A New York City Perspective.","author":"KA Egol","year":"2020","journal-title":"J Orthop Trauma"},{"key":"pone.0263680.ref010","article-title":"Hip Fracture Outcomes During the COVID-19 Pandemic: Early Results from New York","author":"DG LeBrun","year":"2020","journal-title":"J Orthop Trauma"},{"key":"pone.0263680.ref011","article-title":"Mortality Rates of Patients with Proximal Femoral Fracture in a Worldwide Pandemic: Preliminary Results of the Spanish HIP-COVID Observational Study.","author":"JM Mu\u00f1oz Vives","year":"2020","journal-title":"J Bone Joint Surg Am"},{"key":"pone.0263680.ref012","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/2151458513484759","article-title":"The effectiveness of a geriatric hip fracture clinical pathway in reducing hospital and rehabilitation length of stay and improving short-term mortality rates.","volume":"4","author":"T-W Lau","year":"2013","journal-title":"Geriatr Orthop Surg Rehabil"},{"key":"pone.0263680.ref013","first-page":"16","article-title":"Who benefits from orthogeriatric treatment? Results from the Trondheim hip-fracture trial.","author":"A Prestmo","year":"2016","journal-title":"BMC Geriatr"},{"key":"pone.0263680.ref014","first-page":"17","article-title":"Effects of interventions on trajectories of health-related quality of life among older patients with hip fracture: a prospective randomized controlled trial.","author":"M-Y Tseng","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"pone.0263680.ref015","unstructured":"Les r\u00e9sultats des recensements de la population | Insee. [cited 8 Oct 2020]. Available: https:\/\/www.insee.fr\/fr\/information\/2008354"},{"key":"pone.0263680.ref016","unstructured":"Fichier des personnes d\u00e9c\u00e9d\u00e9es (D\u00e9c\u00e8s)\u2014data.gouv.fr. [cited 8 Oct 2020]. Available: \/en\/datasets\/fichier-des-personnes-decedees\/"},{"key":"pone.0263680.ref017","unstructured":"Charlson Comorbidity Index (CCI). In: MDCalc [Internet]. [cited 7 Oct 2021]. Available: https:\/\/www.mdcalc.com\/charlson-comorbidity-index-cci"},{"key":"pone.0263680.ref018","article-title":"adresse.data.gouv.fr [Internet].","author":"CSV G\u00e9ocoder un fichier"},{"key":"pone.0263680.ref019","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.18632\/aging.103201","article-title":"Preventive strategy for the clinical treatment of hip fractures in the elderly during the COVID-19 outbreak: Wuhan\u2019s experience","volume":"12","author":"J Liu","year":"2020","journal-title":"Aging (Albany NY)."},{"key":"pone.0263680.ref020","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1302\/0301-620X.102B6.BJJ-2020-0537","article-title":"The management of emergency spinal surgery during the COVID-19 pandemic in Italy","volume":"102-B","author":"PD Giorgi","year":"2020","journal-title":"Bone Joint J"},{"key":"pone.0263680.ref021","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.2106\/JBJS.20.00617","article-title":"Treatment of Proximal Femoral Fragility Fractures in Patients with COVID-19 During the SARS-CoV-2","volume":"102","author":"F Catellani","year":"2020","journal-title":"Outbreak in Northern Italy. J Bone Joint Surg Am"},{"key":"pone.0263680.ref022","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.injury.2020.06.006","article-title":"The Evolving COVID-19 Effect on Hip Fracture Patients.","volume":"51","author":"JN Hadfield","year":"2020","journal-title":"Injury"},{"key":"pone.0263680.ref023","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s00167-020-06023-3","article-title":"Management of orthopaedic and traumatology patients during the Coronavirus disease (COVID-19) pandemic in northern Italy","volume":"28","author":"PS Randelli","year":"2020","journal-title":"Knee surgery, sports traumatology, arthroscopy: official journal of the ESSKA"},{"key":"pone.0263680.ref024","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1007\/s00167-020-06022-4","article-title":"COVID-19 coronavirus: recommended personal protective equipment for the orthopaedic and trauma surgeon","volume":"28","author":"MT Hirschmann","year":"2020","journal-title":"Knee surgery, sports traumatology, arthroscopy: official journal of the ESSKA"},{"key":"pone.0263680.ref025","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/1747493020923472","article-title":"COVID-19 and stroke-A global World Stroke Organization perspective. International Journal of Stroke","volume":"15","author":"HS Markus","year":"2020","journal-title":"Official Journal of the International Stroke Society"},{"key":"pone.0263680.ref026","first-page":"22","article-title":"Lessons Learnt from COVID-19: How Can We Prepare for Another Pandemic?","volume":"1","author":"MI Ehrlich","year":"2020","journal-title":"Arch Cancer Biol Ther"},{"key":"pone.0263680.ref027","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jor.2020.06.001","article-title":"Challenges and strategies in management of osteoporosis and fragility fracture care during COVID-19 pandemic","volume":"21","author":"GK Upadhyaya","year":"2020","journal-title":"J Orthop"},{"key":"pone.0263680.ref028","article-title":"The Impact of Coronavirus Disease 2019 (COVID-19) on Healthcare-Associated Infections.","author":"MA Baker","year":"2021","journal-title":"Clinical Infectious Diseases"},{"key":"pone.0263680.ref029","article-title":"Thirty-day mortality following surgical management of hip fractures during the COVID-19 pandemic: findings from a prospective multi-centre UK study","author":"A Narang","year":"2020","journal-title":"Int Orthop."},{"key":"pone.0263680.ref030","doi-asserted-by":"crossref","first-page":"e325","DOI":"10.1097\/BOT.0000000000001889","article-title":"Thirty-Day Mortality Rate of Patients With Hip Fractures During the COVID-19 Pandemic: A Single Centre Prospective Study in the United Kingdom","volume":"34","author":"A Thakrar","year":"2020","journal-title":"Journal of Orthopaedic Trauma"},{"key":"pone.0263680.ref031","article-title":"North West COVID NOF Study Group. 30-day mortality for fractured neck of femur patients with concurrent COVID-19 infection","author":"L Dupley","year":"2020","journal-title":"European Journal of Orthopaedic Surgery & Traumatology: Orthopedie Traumatologie"},{"key":"pone.0263680.ref032","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.injury.2008.01.048","article-title":"Influence of optimised treatment of people with hip fracture on time to operation, length of hospital stay, reoperations and mortality within 1 year","volume":"39","author":"A Hommel","year":"2008","journal-title":"Injury"},{"key":"pone.0263680.ref033","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1302\/0301-620X.102B9.BJJ-2020-1127.R1","article-title":"The effects of COVID-19 on perioperative morbidity and mortality in patients with hip fractures","volume":"102-B","author":"B Kayani","year":"2020","journal-title":"The Bone & Joint Journal"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0263680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T18:36:44Z","timestamp":1645814204000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0263680"}},"subtitle":[],"editor":[{"given":"Robert Daniel","family":"Blank","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0263680","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,25]]}}}