{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:58:16Z","timestamp":1793051896244,"version":"4.5.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Irritable bowel syndrome (IBS) affects 9,2% of the global population and places a considerable burden on healthcare systems. Most medications for treating IBS, including spasmolytics, laxatives, and antidiarrheals, have low efficacy. Effective and safe therapeutic treatments have yet to be developed for IBS.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Purpose<\/jats:title><jats:p>This study assessed the efficacy and safety of a food supplement containing standardized menthol, limonene, and gingerol in human participants with IBS or IBS\/functional dyspepsia (FD).<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Design<\/jats:title><jats:p>A double-blind, randomized, placebo-controlled trial.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Methods<\/jats:title><jats:p>We randomly assigned 56 patients with IBS or IBS\/FD to an intervention group (Group 1) or control group (Group 2) that were given supplement or placebo, respectively, in addition to the standard treatment regimen for 30 d. Three outpatient visits were conducted during the study. Symptom severity was measured at each visit using a 7\u00d77 questionnaire. Qualitative and quantitative composition of the intestinal microbiota were assessed at visits 1 and 3 based on 16S rRNA gene sequencing.<\/jats:p><\/jats:sec><jats:sec id=\"sec005\"><jats:title>Results<\/jats:title><jats:p>At visit 1 (before treatment), the median total 7\u00d77 questionnaire score was in the moderately ill range for both groups, with no difference between the groups (<jats:italic>p<\/jats:italic>= 0.1). At visit 2, the total 7\u00d77 score decreased to mildly ill, with no difference between the groups (<jats:italic>p<\/jats:italic>= 0.4). At visit 3, the total score for group 1 indicated borderline illness and for group 2 remained indicated mild illness (<jats:italic>p<\/jats:italic>= 0.009). Even though we observed some variations in gut microbiota between the groups, we did not find any statistically significant changes.<\/jats:p><\/jats:sec><jats:sec id=\"sec006\"><jats:title>Conclusion<\/jats:title><jats:p>The food supplement with standardized menthol, limonene, and gingerol content increased the efficacy of standard therapy in IBS and FD patients. The use of the supplement did not cause any obvious side effects.<\/jats:p><\/jats:sec><jats:sec id=\"sec007\"><jats:title>Registration<\/jats:title><jats:p>ClinicalTrials.gov Identifier:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04484467\" xlink:type=\"simple\">NCT04484467<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0263880","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T22:08:47Z","timestamp":1655330927000},"page":"e0263880","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy and safety of a food supplement with standardized menthol, limonene, and gingerol content in patients with irritable bowel syndrome: A double-blind, randomized, placebo-controlled trial"],"prefix":"10.1371","volume":"17","author":[{"given":"Vladimir T.","family":"Ivashkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Kudryavtseva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George S.","family":"Krasnov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9710-7490","authenticated-orcid":true,"given":"Yuri M.","family":"Poluektov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7847-2716","authenticated-orcid":true,"given":"Margarita A.","family":"Morozova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg S.","family":"Shifrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan G.","family":"Beniashvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarina A.","family":"Mamieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra L.","family":"Kovaleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5506-5555","authenticated-orcid":true,"given":"Anatoly I.","family":"Ulyanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta A.","family":"Trush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Erlykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-120X","authenticated-orcid":true,"given":"Elena A.","family":"Poluektova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"pone.0263880.ref001","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s12664-014-0447-1","article-title":"Prevalence of irritable bowel syndrome and functional dyspepsia, overlapping symptoms, and associated factors in a general population of Bangladesh","volume":"33","author":"I Perveen","year":"2014","journal-title":"Indian J Gastroenterol"},{"key":"pone.0263880.ref002","article-title":"Symptom burden and consulting behavior in patients with overlapping functional disorders in the US population","author":"N Vakil","year":"2016","journal-title":"United Eur Gastroenterol J"},{"key":"pone.0263880.ref003","doi-asserted-by":"crossref","first-page":"252","DOI":"10.5056\/jnm.2011.17.3.252","article-title":"Irritable bowel syndrome, gut microbiota and probiotics","volume":"17","author":"BJ Lee","year":"2011","journal-title":"J Neurogastroenterol Motil"},{"key":"pone.0263880.ref004","article-title":"Ford AC. 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