{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:01:39Z","timestamp":1787022099070,"version":"build-2736575974"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Impairment of cognitive functions is commonly observed in temporal lobe epilepsy (TLE). The aim of this study was to assess visuospatial memory functions and memory-related networks using an adapted version of\n                      <jats:italic>Roland\u2019s Hometown Walking<\/jats:italic>\n                      (RHWT) functional MRI (fMRI) task in patients with TLE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used fMRI to study activation patterns based on a visuospatial memory paradigm in 32 TLE patients (9 right; 23 left) and also within subgroups of lesional and non-lesional TLE. To test for performance, a correlational analysis of fMRI activation patterns and out-of-scanner neuropsychological visuospatial memory testing was performed. Additionally, we assessed memory-related networks using functional connectivity (FC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Greater contralateral than ipsilateral mesiotemporal (parahippocampal gyrus\/hippocampus) activation was observed in left (n = 23)\/right (n = 9) TLE. In lesional left TLE (n = 17), significant activations were seen in right more than left mesiotemporal areas (parahippocampal gyrus), while non-lesional left TLE patients (n = 6) showed significant bilateral (left&gt;right) activations in mesiotemporal structures (parahippocampal gyrus). In left TLE, visuospatial cognitive testing correlated with fMRI activations in left (parahippocampal gyrus) and right mesiotemporal structures (hippocampus), characterized by greater fMRI activation being associated with better memory scores. In right TLE, higher scores in visuospatial memory testing were associated with greater fMRI activations in left and right insular regions. FC patterns of memory-related networks differ in right and left TLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While TLE in general leads to asymmetrical mesiotemporal activation, lesion-induced and non-lesional TLE patients reveal different memory fMRI activation patterns. In right TLE, insular regions try to compensate for impaired right mesiotemporal structures during the performance of visuospatial tasks. Underlying functional visuospatial memory networks differ in right and left TLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0264349","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T13:34:32Z","timestamp":1645536872000},"page":"e0264349","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Imaging visuospatial memory in temporal lobe epilepsy\u2014Results of an fMRI 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review of the epidemiology of temporal lobe epilepsy","volume":"2012","author":"JF T\u00e9llez-Zenteno","year":"2012","journal-title":"Epilepsy Res Treat"},{"key":"pone.0264349.ref002","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1056\/NEJM200002033420503","article-title":"Early identification of refractory epilepsy","volume":"342","author":"P Kwan","year":"2000","journal-title":"N Engl J Med"},{"key":"pone.0264349.ref003","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(11)60890-8","article-title":"The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study","volume":"378","author":"J de Tisi","year":"2011","journal-title":"Lancet"},{"key":"pone.0264349.ref004","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2176\/nmc.ra.2016-0186","article-title":"Non-invasive evaluation for epilepsy surgery","volume":"56","author":"M Iwasaki","year":"2016","journal-title":"Neurol Med Chir 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Janszky","year":"2005","journal-title":"Epilepsia"},{"key":"pone.0264349.ref009","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/jnnp-2017-315732","article-title":"Functional connectivity disturbances of the ascending reticular activating system in temporal lobe epilepsy","volume":"88","author":"DJ Englot","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"pone.0264349.ref010","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.yebeh.2018.01.027","article-title":"Task activation and functional connectivity show concordant memory laterality in temporal lobe epilepsy","volume":"81","author":"N Sideman","year":"2018","journal-title":"Epilepsy Behav"},{"key":"pone.0264349.ref011","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1089\/brain.2013.0158","article-title":"Hippocampal functional connectivity patterns during spatial working memory differ in right versus left temporal lobe epilepsy","volume":"3","author":"G Doucet","year":"2013","journal-title":"Brain Connect"},{"key":"pone.0264349.ref012","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3389\/fnhum.2013.00624","article-title":"Imaging structural and functional brain networks in temporal lobe epilepsy","volume":"7","author":"BC Bernhardt","year":"2013","journal-title":"Front Hum Neurosci"},{"key":"pone.0264349.ref013","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/hbm.22726","article-title":"Bringing memory fMRI to the clinic: comparison of seven memory fMRI protocols in temporal lobe epilepsy","volume":"36","author":"K Towgood","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"pone.0264349.ref014","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-neuro-071013-014030","article-title":"The brain\u2019s default mode network","volume":"38","author":"ME Raichle","year":"2015","journal-title":"Annu Rev Neurosci"},{"key":"pone.0264349.ref015","volume-title":"Therapieassoziierte kognitive Funktionsst\u00f6rungen und deren psychometrische Erfassung bei Patienten mit prim\u00e4ren Gehirntumoren","author":"S. Rogowski","year":"2017","edition":"1"},{"key":"pone.0264349.ref016","volume-title":"HAWIE-R: Hamburg-Wechsler-Intelligenztest f\u00fcr Erwachsene, Revision 1991","author":"U. Tewes","year":"1991"},{"key":"pone.0264349.ref017","volume-title":"Neuropsychologie der Schizophrenie: Symptome, Kognition, Gehirn","author":"T Kircher","year":"2008","edition":"1"},{"key":"pone.0264349.ref018","doi-asserted-by":"crossref","DOI":"10.1037\/14538-000","volume-title":"The maze test and clinical psychology","author":"SD Porteus","year":"1959","edition":"1"},{"key":"pone.0264349.ref019","doi-asserted-by":"crossref","DOI":"10.1007\/3-540-28507-5","volume-title":"Psychologische Diagnostik und Intervention.","author":"M Amelang","year":"2006","edition":"4"},{"key":"pone.0264349.ref020","volume-title":"Leistungspr\u00fcfsystem (LPS)","author":"W. Horn","year":"1983","edition":"2"},{"key":"pone.0264349.ref021","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hbm.460020402","article-title":"Statistical parametric maps in functional imaging: a general linear approach","volume":"2","author":"K Friston","year":"1995","journal-title":"Hum Brain Mapp"},{"key":"pone.0264349.ref022","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejrad.2018.12.007","article-title":"Reorganization of brain networks following carotid endarterectomy: an exploratory study using resting state functional connectivity with a focus on the changes in Default Mode Network connectivity","volume":"110","author":"M Porcu","year":"2019","journal-title":"Eur J Radiol"},{"key":"pone.0264349.ref023","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","author":"S Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connect"},{"key":"pone.0264349.ref024","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/hbm.1048","article-title":"A method for making group inferences from functional MRI data using independent component analysis","volume":"14","author":"VD Calhoun","year":"2001","journal-title":"Hum Brain Mapp"},{"key":"pone.0264349.ref025","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1093\/brain\/awq006","article-title":"Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection","volume":"133","author":"SB Bonelli","year":"2010","journal-title":"Brain"},{"key":"pone.0264349.ref026","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1212\/01.wnl.0000191303.91188.00","article-title":"Amygdala fMRI lateralizes temporal lobe epilepsy","volume":"66","author":"M Schacher","year":"2006","journal-title":"Neurology"},{"key":"pone.0264349.ref027","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jocn.2018.06.020","article-title":"Memory loss and memory reorganization patterns in temporal lobe epilepsy patients undergoing anterior temporal lobe resection, as demonstrated by pre-versus post-operative functional MRI","volume":"55","author":"C Limotai","year":"2018","journal-title":"J Clin Neurosci"},{"key":"pone.0264349.ref028","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/epi.13699","article-title":"MRI-negative temporal lobe epilepsy-what do we know?","volume":"58","author":"W Muhlhofer","year":"2017","journal-title":"Epilepsia"},{"key":"pone.0264349.ref029","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2147\/NDT.S56404","article-title":"Identifying the affected hemisphere with a multimodal approach in MRI-positive or negative, unilateral or bilateral temporal lobe epilepsy","volume":"10","author":"J Zhang","year":"2014","journal-title":"Neuropsychiatr Dis Treat"},{"key":"pone.0264349.ref030","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/epi.13456","article-title":"Resting-state functional MRI distinguishes temporal lobe epilepsy subtypes","volume":"57","author":"A Reyes","year":"2016","journal-title":"Epilepsia"},{"key":"pone.0264349.ref031","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/brcg.1999.1095","article-title":"Hippocampal involvement in spatial and working memory: a structural MRI analysis of patients with unilateral mesial temporal lobe sclerosis","volume":"41","author":"S Abrahams","year":"1999","journal-title":"Brain Cogn"},{"key":"pone.0264349.ref032","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0028-3932(97)00161-9","article-title":"Spatial memory deficits in patients with lesions to the right hippocampus and to the right parahippocampal cortex","volume":"36","author":"VD Bohbot","year":"1998","journal-title":"Neuropsychologia"},{"key":"pone.0264349.ref033","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0896-6273(02)00830-9","article-title":"The human hippocampus and spatial and episodic memory","volume":"35","author":"N Burgess","year":"2002","journal-title":"Neuron"},{"key":"pone.0264349.ref034","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00429-010-0262-0","article-title":"Saliency, switching, attention and control: a network model of insula function","volume":"214","author":"V Menon","year":"2010","journal-title":"Brain Struct Funct"},{"key":"pone.0264349.ref035","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fnhum.2018.00337","article-title":"The 100 most cited papers concerning the insular cortex of the brain: a bibliometric analysis","volume":"12","author":"AWK Yeung","year":"2018","journal-title":"Front Hum 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