{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T02:12:10Z","timestamp":1782180730081,"version":"3.54.5"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swansea Bay University Health Board Research and Development Department"},{"name":"Health Data Research UK"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Aims<\/jats:title>\n<jats:p>To explore differences in the use of lipid lowering therapy and\/or achievement of lipid guideline targets in patients with and without prior depression and influence of sex in very high-risk coronary patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods &amp; findings<\/jats:title>\n<jats:p>A retrospective observational cohort study was conducted using individual-level linked electronic health record data in patients who underwent percutaneous coronary intervention (2012\u20132017) in Wales. The cohort comprised of 13,781 patients (27.4% female), with 26.1% having prior depression. Lipid levels were recorded in 10,050 patients of whom 25% had depression. History of depression was independently associated with not having lipids checked (OR 0.79 95%CI 0.72\u20130.87 p&lt;0.001). Patients with prior depression were less likely to achieve targets for low density lipoprotein cholesterol (LDL-C &lt;1.8mmol\/l), non-high density lipoprotein cholesterol (non-HDL-C &lt;2.6mmol\/l) and triglycerides (&lt;2.3mmol\/l) than patients without depression (OR 0.86 95%CI 0.78\u20130.96 p = 0.007, OR 0.80 95%CI 0.69\u20130.92 p = 0.003 &amp; OR 0.69 95CI% 0.61\u20130.79 p&lt;0.001 respectively). Females were less likely to achieve targets for LDL-C and non-HDL-C than males (OR 0.55 95%CI 0.50\u20130.61 p&lt;0.001 &amp; OR 0.63 95%CI 0.55\u20130.73 p&lt;0.001). There was an additive effect of depression and sex; females with depression were not only least likely to be tested (OR 0.74 95%CI 0.65\u20130.84 p&lt;0.001) but also (where levels were known) less likely to achieve LDL-C (OR 0.47 95%CI 0.41\u20130.55 p&lt;0.001) and non-HDL-C targets (OR 0.50 95%CI 0.41\u20130.60 p&lt;0.001). It was not possible to look at the influence of medication adherence on achievement of lipid targets due to limitations of the use of anonymised routinely-held clinical care data.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Patients with prior depression were less likely to have their lipids monitored and achieve guideline targets within 1-year. Females with depression are the least likely to be tested and achieve lipid targets, suggesting not only a greater risk of future events, but also an opportunity to improve care.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0264529","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T18:40:25Z","timestamp":1645814425000},"page":"e0264529","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Achievement of European Society of Cardiology\/European Atherosclerosis Society lipid targets in very high-risk patients: Influence of depression and sex"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5164-6416","authenticated-orcid":true,"given":"Elizabeth 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