{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:26:13Z","timestamp":1793834773153,"version":"4.6.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["Grant ID: RS 17-08196"],"award-info":[{"award-number":["Grant ID: RS 17-08196"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Neonatal jaundice (NNJ) is a major cause of preventable childhood mortality and long-term impairment especially in countries with significant prevalence of the inherited condition, glucose-6-phosphate dehydrogenase (G6PD) defect. In Ghana, routine screening of pregnant women for G6PD defect is standard care. Prevention of poor health outcomes from NNJ is contingent on population health literacy and early diagnosis. As part of a project to evaluate a screening tool for NNJ, we assessed the knowledge, attitude, and perceptions of Ghanaian mothers on NNJ at baseline.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>Using a cross-sectional design, mothers attending antenatal and postnatal clinics at 3 selected health facilities in 2 geographical regions of Ghana were interviewed. Data on mothers\u2019 understanding, perceptions, beliefs, and actions towards NNJ were evaluated. Chi-square test was used to determine the association between selected maternal characteristics and knowledge, attitude, and perception to NNJ.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>Of the 504 mothers interviewed, 428(85.4%) had heard about NNJ, 346 (68.7%) said the earliest signs are seen in the eyes, 384(76.2%) knew NNJ may be harmful and 467(92.7%) recommended seeking healthcare for the jaundiced newborn. None of the women knew about G6PD or their G6PD status following antenatal screening. Most did not know the signs\/symptoms of severe NNJ. Of the 15 mothers who had had a jaundiced neonate, cost was the most perceived (8 out of 15) barrier to accessing health care. There were significant associations (p-value \u2264 0.05) between maternal age, educational level, and knowledge of NNJ.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>Despite the high level of awareness of NNJ, gaps still exit in the knowledge, attitudes and perceptions of mothers concerning NNJ. Improving education of women about the causes, symptoms\/signs, and the role of G6PD in severe NNJ is recommended. Addressing barriers to accessing healthcare for the jaundiced infant may enhance timely management of NNJ and reduce the associated complications and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0264694","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T19:11:42Z","timestamp":1646334702000},"page":"e0264694","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Neonatal jaundice in Ghanaian children: Assessing maternal knowledge, attitude, and perceptions"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8836-7154","authenticated-orcid":true,"given":"Nana Ayegua Hagan","family":"Seneadza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Insaidoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Boye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-612X","authenticated-orcid":true,"given":"Mary","family":"Ani-Amponsah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Meek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-5365","authenticated-orcid":true,"given":"Christabel","family":"Enweronu-Laryea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"pone.0264694.ref001","unstructured":"National Institute for Health and Clinical Excellence L. \u201cNICE clinical guideline 98: Neonatal jaundice. https:\/\/www.nice.org.uk\/guidance\/cg98\/evidence\/full-guideline-245411821"},{"issue":"3","key":"pone.0264694.ref002","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.siny.2006.02.002","article-title":"Early recognition of neonatal hyperbilirubinemia and its emergent management","volume":"11","author":"H Smitherman","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"issue":"9607","key":"pone.0264694.ref003","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0140-6736(08)60106-3","article-title":"Clinical signs that predict severe illness in children under age 2 months: a multicentre study","volume":"371","year":"2008","journal-title":"Lancet"},{"key":"pone.0264694.ref004","unstructured":"Chapter 13. Neonatal Jaundice in Low- and Middle-Income Countries | Care of the Jaundiced Neonate | AccessPediatrics | McGraw-Hill Medical. https:\/\/accesspediatrics.mhmedical.com\/content.aspx?sectionid=41538486&bookid=528"},{"issue":"9814","key":"pone.0264694.ref005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0140-6736(11)61577-8","article-title":"Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: A systematic review","volume":"379","author":"MK Mwaniki","year":"2012","journal-title":"Lancet"},{"key":"pone.0264694.ref006","unstructured":"Institute of Medicine (US) Committee on Nervous System Disorders in Developing Countries. Neurological, Psychiatric, and Developmental Disorders: Meeting the Challenge in the Developing World. Washington (DC): National Academies Press (US); 2001."},{"issue":"Supplement","key":"pone.0264694.ref007","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1542\/peds.2014-3330K","article-title":"Classification and Risk Factors for Cerebral Palsy in the Korle Bu Teaching Hospital, Accra: A Case-Control Study","volume":"135","author":"E Adei-Atiemo","year":"2015","journal-title":"Pediatrics"},{"issue":"1","key":"pone.0264694.ref008","first-page":"13","article-title":"Aetiology of mental retardation in Nigerian children around Enugu","volume":"31","author":"I Gi","year":"1985","journal-title":"Cent Afr J Med"},{"issue":"No 3","key":"pone.0264694.ref009","article-title":"Further observations on factors associated with neonatal jaundice in Accra. 1964","volume":"Vol 3","author":"C JP Gilbert","year":"1964","journal-title":"Ghana Med J"},{"issue":"1","key":"pone.0264694.ref010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/tropej\/fmi042","article-title":"Glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia","volume":"52","author":"E Atay","year":"2006","journal-title":"J Trop Pediatr"},{"issue":"1","key":"pone.0264694.ref011","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s13104-017-2591-z","article-title":"Socio-demographic determinants of skilled birth attendant at delivery in rural southern Ghana","volume":"10","author":"AK Manyeh","year":"2017","journal-title":"BMC Res Notes"},{"issue":"2","key":"pone.0264694.ref012","first-page":"167","article-title":"Newborn Care Knowledge and Practices among Mothers Attending Pediatric Outpatient Clinic of a Hospital in Karachi, Pakistan","volume":"8","author":"S Gul","year":"2014","journal-title":"Int J Health Sci (Qassim)"},{"issue":"1","key":"pone.0264694.ref013","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.NMC.0000366803.88540.1d","article-title":"Maternal experience with neonatal jaundice","volume":"35","author":"M Brethauer","year":"2010","journal-title":"MCN Am J Matern Nurs"},{"issue":"3","key":"pone.0264694.ref014","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4103\/1117-1936.170741","article-title":"Neonatal Jaundice: Knowledge, Attitude and practices of mothers in Mosan-Okunola community, Lagos, Nigeria","volume":"22","author":"O Goodman","year":"2015","journal-title":"Niger Postgrad Med J"},{"issue":"36","key":"pone.0264694.ref015","doi-asserted-by":"crossref","first-page":"e4804","DOI":"10.1097\/MD.0000000000004804","article-title":"Perceptions, practices, and traditional beliefs related to neonatal jaundice among Egyptian mothers","volume":"95","author":"EMI Moawad","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"pone.0264694.ref016","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/1471-2431-14-264","article-title":"Care practices and traditional beliefs related to neonatal jaundice in northern Vietnam: A population-based, cross-sectional descriptive study","volume":"14","author":"LT Le","year":"2014","journal-title":"BMC Pediatr"},{"key":"pone.0264694.ref017","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/1472-6963-14-192","article-title":"Pattern and predictors of maternal care-seeking practices for severe neonatal jaundice in Nigeria: A multi-centre survey","volume":"14","author":"C V. Ezeaka","year":"2014","journal-title":"BMC Health Services Research"},{"issue":"1","key":"pone.0264694.ref018","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4103\/1119-3077.146976","article-title":"Maternal knowledge and care-seeking behaviors for newborn jaundice in Sagamu, Southwest Nigeria","volume":"18","author":"TA Ogunlesi","year":"2015","journal-title":"Niger J Clin Pract"},{"issue":"4","key":"pone.0264694.ref019","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4314\/gmj.v53i4.3","article-title":"Neonatal jaundice: Awareness, perception and preventive practices in expectant mothers","volume":"53","author":"KH Amegan-Aho","year":"2019","journal-title":"Ghana Med J"},{"key":"pone.0264694.ref020","unstructured":"Ghana Statistical Service\u2014GSS, Ghana Health Service\u2014GHS, and ICF. 2018. Ghana Maternal Health Survey 2017. Accra, Ghana: GSS, GHS, and ICF."},{"issue":"2","key":"pone.0264694.ref021","doi-asserted-by":"crossref","first-page":"97","DOI":"10.7326\/0003-4819-155-2-201107190-00005","article-title":"Low Health Literacy and Health Outcomes: An Updated Systematic Review","volume":"155","author":"ND Berkman","year":"2011","journal-title":"Annals of Internal Medicine"},{"issue":"2","key":"pone.0264694.ref022","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/jcn.JCN_119_18","article-title":"Mothers\u2019 perception of neonatal jaundice in Jazan Region, KSA","volume":"8","author":"H Magfouri","year":"2019","journal-title":"J Clin Neonatol"},{"issue":"3","key":"pone.0264694.ref023","first-page":"239","article-title":"Malaysian Mothers\u2019 Knowledge & Practices on Care of Neonatal Jaundice","volume":"66","author":"NY Boo","year":"2011","journal-title":"Med J Malaysia"},{"issue":"2","key":"pone.0264694.ref024","doi-asserted-by":"crossref","first-page":"42","DOI":"10.18311\/jhsr\/2016\/v1\/i2\/4918","article-title":"Neonatal Jaundice: Evaluating the Knowledge and Practice of Expectant Mothers in Aba, Nigeria","volume":"1","author":"CN Onyearugha","year":"2016","journal-title":"J Heal Sci Res"},{"issue":"3","key":"pone.0264694.ref025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4038\/sljch.v48i3.8755","article-title":"Knowledge about neonatal jaundice among Nepalese mothers","volume":"48","author":"S Shrestha","year":"2019","journal-title":"Sri Lanka J Child Heal"},{"issue":"9","key":"pone.0264694.ref026","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s00431-020-03623-6","article-title":"Validation of a neonatal skin color scale","volume":"179","author":"S Maya-Enero","year":"2020","journal-title":"Eur J Pediatr"},{"issue":"3","key":"pone.0264694.ref027","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-0312","article-title":"Use of a smartphone app to assess neonatal jaundice","volume":"140","author":"JA Taylor","year":"2017","journal-title":"Pediatrics"},{"issue":"11","key":"pone.0264694.ref028","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1364\/BOE.6.004529","article-title":"Screening neonatal jaundice based on the sclera color of the eye using digital photography","volume":"6","author":"TS Leung","year":"2015","journal-title":"Biomed Opt Express"},{"issue":"1","key":"pone.0264694.ref029","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1365-3156.2011.02885.x","article-title":"Health risks of using mothballs in Greater Accra","volume":"17","author":"S Soghoian","year":"2012","journal-title":"Ghana. Trop Med Int Heal"},{"issue":"6","key":"pone.0264694.ref030","first-page":"601","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"67","author":"E Beutler","year":"1989","journal-title":"Bull World Health Organ"},{"issue":"4","key":"pone.0264694.ref031","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3345\/kjp.2017.60.4.106","article-title":"Neonatal indirect hyperbilirubinemia and glucose-6-phosphate dehydrogenase deficiency","volume":"60","author":"HM Isa","year":"2017","journal-title":"Korean J Pediatr"},{"key":"pone.0264694.ref032","first-page":"13","article-title":"Naphthalene Mothballs: Emerging and Recurring Issues and their Relevance to Environmental Health","volume":"7","author":"DL Sudakin","year":"2011","journal-title":"Curr Top Toxicol"},{"issue":"3","key":"pone.0264694.ref033","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/pubmed\/fdi031","article-title":"Mode of questionnaire administration can have serious effects on data quality","volume":"27","author":"A. Bowling","year":"2005","journal-title":"J Public Health (Bangkok)"},{"issue":"4","key":"pone.0264694.ref034","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/archdischild-2015-309450","article-title":"Questionnaire design: The good, the bad and the pitfalls","volume":"101","author":"D Thwaites Bee","year":"2016","journal-title":"Arch Dis Child Educ Pract Ed"},{"key":"pone.0264694.ref035","doi-asserted-by":"crossref","first-page":"105257","DOI":"10.1016\/j.worlddev.2020.105257","article-title":"Informal mhealth at scale in Africa: Opportunities and challenges","volume":"Volume 140","author":"K Hampshire","year":"2021","journal-title":"World Development"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0264694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T10:48:06Z","timestamp":1700304486000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0264694"}},"subtitle":[],"editor":[{"given":"Barbara Wilson","family":"Engelhardt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,3]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0264694","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,3]]}}}