{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:32:05Z","timestamp":1772213525380,"version":"3.50.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Biomedical Research Program and the Biostatistics, Epidemiology, and Biomathematics Research Core, both at Weill Cornell Medicine \u2013 Qatar"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Limited data are available regarding antimicrobial resistance in\n                    <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n                    strains circulating in WHO Eastern Mediterranean Region (EMR). We investigated the antimicrobial susceptibility\/resistance of\n                    <jats:italic>N<\/jats:italic>\n                    .\n                    <jats:italic>gonorrhoeae<\/jats:italic>\n                    isolates to five antimicrobials (ceftriaxone, azithromycin, ciprofloxacin, tetracycline, and benzylpenicillin) currently or previously used for gonorrhoea treatment in Qatar, 2017\u20132020. Minimum inhibitory concentrations (MICs; mg\/L) of antimicrobials were determined using Etest on gonococcal isolates collected during January 1, 2017-August 30, 2020 at Hamad Medical Corporation, a national public healthcare provider. During 2017\u20132020, resistance in isolates from urogenital sites of 433 patients was 64.7% (95% CI: 59.5\u201369.6%; range: 43.9\u201378.7%) for ciprofloxacin, 50.7% (95% CI: 45.3\u201356.1%; range: 41.3\u201370.4%) for tetracycline, and 30.8% (95% CI: 26.3\u201335.6%; range: 26.7\u201335.8%) for benzylpenicillin. Percentage of isolates non-susceptible to azithromycin was 4.1% (95% CI: 2.0\u20137.4%; range: 2.7\u20134.8%) and all (100%) isolates were susceptible to ceftriaxone. Two (1.6%) isolates from 2019 and one (2.2%) isolate from 2020 had high-level resistance to azithromycin (MIC\u2265256 mg\/L). Overall, 1.0% (4\/418) of isolates had a ceftriaxone MIC of 0.25 mg\/L, which is at the ceftriaxone susceptibility breakpoint (MIC\u22640.25 mg\/L). Treatment with ceftriaxone 250 mg plus azithromycin 1 g can continuously be recommended for gonorrhoea therapy in Qatar. Continued quality-assured gonococcal AMR surveillance is warranted in EMR.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0264737","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T13:45:38Z","timestamp":1646228738000},"page":"e0264737","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["First characterisation of antimicrobial susceptibility and resistance of Neisseria gonorrhoeae isolates in Qatar, 2017\u20132020"],"prefix":"10.1371","volume":"17","author":[{"given":"Muna","family":"Al-Maslamani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad Bashier Ibrahim","family":"Elmagboul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aslam","family":"Puthiyottil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiam","family":"Chemaitelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj Kizhakkepeedikayil","family":"Varghese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamad Eid","family":"Al Romaihi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed H.","family":"Al-Thani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullatif","family":"Al Khal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Unemo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-0506","authenticated-orcid":true,"given":"Laith J.","family":"Abu-Raddad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"pone.0264737.ref001","first-page":"627","volume-title":"Gonococcal infections in the adult","author":"EW Hook","year":"2007","edition":"4"},{"issue":"1","key":"pone.0264737.ref002","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41572-019-0128-6","article-title":"Gonorrhoea.","volume":"5","author":"M Unemo","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"pone.0264737.ref003","unstructured":"Centers for Disease Control and Prevention. 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