{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:51:09Z","timestamp":1780116669647,"version":"3.54.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Obesity has been indicated to be a risk factor of diverticulosis. However, plausible relationship remained controversial. This cross-sectional study elucidated the association between percentage of body fat and the risk of diverticulosis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The study was conducted at a single medical center in Taiwan from 2000\u20132016 which enrolled 5557 adults with age above 20 years old receiving a health examination including self-reported questionnaires, measurement of percentage of body fat (PBF), blood test and colonoscopy at the Tri-Service General Hospital (TSGH). Logistic regressions were used to analyze the association between PBF and diverticulosis. Further stratification of participants was based on age and gender and three extended models were established for multivariable adjustment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>243 of 3141 males and 103 of 2416 females were diagnosed with having diverticulosis. After covariates adjustment, only participants in the highest quartile of PBF (Q4 \u226533.8%) showed significantly positive association with the risk diverticulosis (OR 2.089, p &lt;0.001). In subgroup analysis, the odds ratio for having diverticulosis in females was significantly higher than in males. In addition, We found that the odds ratio of having diverticulosis was higher in the group older than 60 years old compared to the younger group (OR 1.052; p&lt;0.001; OR 1.043; p&lt;0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>In conclusion, PBF was a potential risk factor of diverticulosis. Individuals with higher PBF exhibits increased risk of diverticulosis, especially in females. Furthermore, bioelectrical impedance analysis may create a simple, available and radiation-free way to assess the risk of diverticulosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0264746","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T18:36:33Z","timestamp":1646159793000},"page":"e0264746","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Percentage of body fat is associated with increased risk of diverticulosis: A cross sectional study"],"prefix":"10.1371","volume":"17","author":[{"given":"Chi-Wei","family":"Shih","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-230X","authenticated-orcid":true,"given":"Wei-Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"issue":"9409","key":"pone.0264746.ref001","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(04)15597-9","article-title":"Diverticular disease of the colon","volume":"363","author":"N Stollman","year":"2004","journal-title":"Lancet (London, England)"},{"issue":"3","key":"pone.0264746.ref002","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1463-1318.2002.00328.x","article-title":"Diverticular disease of the colon and concomitant abnormalities in patients undergoing endoscopic evaluation of the large bowel","volume":"4","author":"RJ Loffeld","year":"2002","journal-title":"Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland"},{"issue":"3","key":"pone.0264746.ref003","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00384-013-1808-4","article-title":"Increase in colonic diverticulosis and diverticular hemorrhage in an aging society: lessons from a 9-year colonoscopic study of 28,192 patients in Japan","volume":"29","author":"N Nagata","year":"2014","journal-title":"International journal of colorectal disease"},{"issue":"3","key":"pone.0264746.ref004","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/nmo.12478","article-title":"Constipation is not associated with colonic diverticula: a multicenter study in Japan","volume":"27","author":"E Yamada","year":"2015","journal-title":"Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society"},{"key":"pone.0264746.ref005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ijsu.2015.04.045","article-title":"Constipation is not associated with diverticular disease\u2014Analysis of 976 patients","volume":"19","author":"T Braunschmid","year":"2015","journal-title":"International journal of surgery (London, England)"},{"issue":"11","key":"pone.0264746.ref006","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1111\/j.1572-0241.1999.01501.x","article-title":"Diagnosis and management of diverticular disease of the colon in adults. Ad Hoc Practice Parameters Committee of the American College of Gastroenterology","volume":"94","author":"NH Stollman","year":"1999","journal-title":"The American journal of gastroenterology"},{"issue":"3","key":"pone.0264746.ref007","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00330-015-3866-1","article-title":"Prevalence and distribution of colonic diverticula assessed with CT colonography (CTC)","volume":"26","author":"CN De Cecco","year":"2016","journal-title":"European radiology"},{"issue":"5","key":"pone.0264746.ref008","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/ajcn\/60.5.757","article-title":"A prospective study of diet and the risk of symptomatic diverticular disease in men","volume":"60","author":"WH Aldoori","year":"1994","journal-title":"The American journal of clinical nutrition"},{"issue":"2","key":"pone.0264746.ref009","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1136\/gut.36.2.276","article-title":"Prospective study of physical activity and the risk of symptomatic diverticular disease in men","volume":"36","author":"WH Aldoori","year":"1995","journal-title":"Gut"},{"issue":"4","key":"pone.0264746.ref010","doi-asserted-by":"crossref","first-page":"e0123688","DOI":"10.1371\/journal.pone.0123688","article-title":"Trend and risk factors of diverticulosis in Japan: age, gender, and lifestyle\/metabolic-related factors may cooperatively affect on the colorectal diverticula formation","volume":"10","author":"N Yamamichi","year":"2015","journal-title":"PloS one"},{"issue":"2","key":"pone.0264746.ref011","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3904\/kjim.2010.25.2.140","article-title":"Clinical characteristics of colonic diverticulosis in Korea: a prospective study","volume":"25","author":"JH Song","year":"2010","journal-title":"The Korean journal of internal medicine"},{"issue":"10","key":"pone.0264746.ref012","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/MCG.0000000000000267","article-title":"Visceral Abdominal Obesity Measured by Computed Tomography is Associated With Increased Risk of Colonic Diverticulosis","volume":"49","author":"N Nagata","year":"2015","journal-title":"Journal of clinical gastroenterology"},{"issue":"1","key":"pone.0264746.ref013","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1463-1318.2005.00847.x","article-title":"The relationship of obesity to the complications of diverticular disease","volume":"8","author":"C Dobbins","year":"2006","journal-title":"Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland"},{"issue":"2","key":"pone.0264746.ref014","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/oxfordjournals.bmb.a011611","article-title":"Assessing obesity: classification and epidemiology","volume":"53","author":"JC Seidell","year":"1997","journal-title":"British medical bulletin"},{"issue":"2","key":"pone.0264746.ref015","doi-asserted-by":"crossref","first-page":"192","DOI":"10.5152\/tjg.2014.4581","article-title":"The relationship between colonic diverticulosis and abdominal visceral and subcutaneous fat accumulation measured by abdominal CT scan","volume":"25","author":"SP Lee","year":"2014","journal-title":"The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology"},{"issue":"3","key":"pone.0264746.ref016","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/01.mco.0000165013.54696.64","article-title":"Limitations and validation of bioelectrical impedance analysis in morbidly obese patients","volume":"8","author":"LZ Coppini","year":"2005","journal-title":"Current opinion in clinical nutrition and metabolic care"},{"issue":"1","key":"pone.0264746.ref017","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1053\/j.gastro.2008.09.025","article-title":"Obesity increases the risks of diverticulitis and diverticular bleeding","volume":"136","author":"LL Strate","year":"2009","journal-title":"Gastroenterology"},{"issue":"5","key":"pone.0264746.ref018","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/MCG.0b013e31826be847","article-title":"Alcohol consumption is a risk factor for colonic diverticulosis","volume":"47","author":"AI Sharara","year":"2013","journal-title":"Journal of clinical gastroenterology"},{"issue":"4","key":"pone.0264746.ref019","first-page":"476","volume":"61","author":"K Wijarnpreecha","year":"2018","journal-title":"Obesity and the Risk of Colonic Diverticulosis: A Meta-analysis"},{"key":"pone.0264746.ref020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12876-015-0267-5","article-title":"Prevalence and risk factors of asymptomatic colorectal diverticulosis in Taiwan","volume":"15","author":"FW Wang","year":"2015","journal-title":"BMC gastroenterology"},{"key":"pone.0264746.ref021","first-page":"1756284819855734","article-title":"Hypertension control and risk of colonic diverticulosis","volume":"12","author":"LX Yeo","year":"2019","journal-title":"Therapeutic advances in gastroenterology"},{"key":"pone.0264746.ref022","doi-asserted-by":"crossref","first-page":"d4131","DOI":"10.1136\/bmj.d4131","article-title":"Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians","volume":"343","author":"FL Crowe","year":"2011","journal-title":"BMJ (Clinical research ed)"},{"issue":"9","key":"pone.0264746.ref023","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1136\/gutjnl-2013-304644","article-title":"Source of dietary fibre and diverticular disease incidence: a prospective study of UK women","volume":"63","author":"FL Crowe","year":"2014","journal-title":"Gut"},{"issue":"2","key":"pone.0264746.ref024","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1053\/j.gastro.2011.10.035","article-title":"A high-fiber diet does not protect against asymptomatic diverticulosis","volume":"142","author":"AF Peery","year":"2012","journal-title":"Gastroenterology"},{"issue":"4","key":"pone.0264746.ref025","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1053\/bega.2002.0323","article-title":"Imaging diverticular disease","volume":"16","author":"S Halligan","year":"2002","journal-title":"Best practice & research Clinical gastroenterology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0264746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T18:36:52Z","timestamp":1646159812000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0264746"}},"subtitle":[],"editor":[{"given":"Gopal Krishna","family":"Dhali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0264746","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}