{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:08:00Z","timestamp":1791446880284,"version":"4.3.3"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"centers for disease control and prevention","doi-asserted-by":"publisher","award":["CK17-1701"],"award-info":[{"award-number":["CK17-1701"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Respiratory syncytial virus (RSV) can cause severe disease in adults with cardiopulmonary conditions, such as congestive heart failure (CHF). We quantified the rate of RSV-associated hospitalization in adults by CHF status using population-based surveillance in the United States.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Population-based surveillance for RSV (RSV-NET) was performed in 35 counties in seven sites during two respiratory seasons (2015\u20132017) from October 1\u2013April 30. Adults (\u226518 years) admitted to a hospital within the surveillance catchment area with laboratory-confirmed RSV identified by clinician-directed testing were included. Presence of underlying CHF was determined by medical chart abstraction. We calculated overall and age-stratified (&lt;65 years and \u226565 years) RSV-associated hospitalization rates by CHF status. Estimates were adjusted for age and the under-detection of RSV. We also report rate differences (RD) and rate ratios (RR) by comparing the rates for those with and without CHF.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>2042 hospitalized RSV cases with CHF status recorded were identified. Most (60.2%, n = 1230) were \u226565 years, and 28.3% (n = 577) had CHF. The adjusted RSV hospitalization rate was 26.7 (95% CI: 22.2, 31.8) per 10,000 population in adults with CHF versus 3.3 (95% CI: 3.3, 3.3) per 10,000 in adults without CHF (RR: 8.1, 95% CI: 6.8, 9.7; RD: 23.4, 95% CI: 18.9, 28.5). Adults with CHF had higher rates of RSV-associated hospitalization in both age groups (&lt;65 years and \u226565 years). Adults \u226565 years with CHF had the highest rate (40.5 per 10,000 population, 95% CI: 35.1, 46.6).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Adults with CHF had 8 times the rate of RSV-associated hospitalization compared with adults without CHF. Identifying high-risk populations for RSV infection can inform future RSV vaccination policies and recommendations.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0264890","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T18:38:13Z","timestamp":1646851093000},"page":"e0264890","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":75,"title":["Rates of respiratory syncytial virus (RSV)-associated hospitalization among adults with congestive heart failure\u2014United States, 2015\u20132017"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-8553","authenticated-orcid":true,"given":"Stephanie A.","family":"Kujawski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Whitaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Ritchey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur L.","family":"Reingold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shua J.","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle P.","family":"Openo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Monroe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Bye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Como-Sabetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant R.","family":"Barney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Muse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina B.","family":"Felsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8851-8482","authenticated-orcid":true,"given":"Ann","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Keipp","family":"Talbot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Schaffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan I.","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle E.","family":"Langley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"issue":"6","key":"pone.0264890.ref001","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMoa0804877","article-title":"The burden of respiratory syncytial virus infection in young children","volume":"360","author":"CB Hall","year":"2009","journal-title":"N Engl J Med"},{"issue":"8","key":"pone.0264890.ref002","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/cid\/cit471","article-title":"High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections","volume":"57","author":"N Lee","year":"2013","journal-title":"Clin Infect Dis"},{"key":"pone.0264890.ref003","article-title":"Severe Morbidity and Mortality Associated With Respiratory Syncytial Virus Versus Influenza Infection in Hospitalized Older Adults","author":"B Ackerson","year":"2018","journal-title":"Clin Infect Dis"},{"issue":"12","key":"pone.0264890.ref004","doi-asserted-by":"crossref","first-page":"ofy316","DOI":"10.1093\/ofid\/ofy316","article-title":"Clinical Features, Severity, and Incidence of RSV Illness During 12 Consecutive Seasons in a Community Cohort of Adults >\/ = 60 Years Old","volume":"5","author":"EA Belongia","year":"2018","journal-title":"Open Forum Infect Dis"},{"issue":"17","key":"pone.0264890.ref005","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1056\/NEJMoa043951","article-title":"Respiratory syncytial virus infection in elderly and high-risk adults","volume":"352","author":"AR Falsey","year":"2005","journal-title":"N Engl J Med"},{"issue":"1","key":"pone.0264890.ref006","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jmv.25285","article-title":"Respiratory syncytial virus-associated illness in adults with advanced chronic obstructive pulmonary disease and\/or congestive heart failure","volume":"91","author":"AR Falsey","year":"2019","journal-title":"J Med Virol"},{"issue":"14","key":"pone.0264890.ref007","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.jacc.2018.02.013","article-title":"Respiratory Syncytial Virus and Associations With Cardiovascular Disease in Adults","volume":"71","author":"KS Ivey","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"pone.0264890.ref008","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1086\/380907","article-title":"Risk factors for severe respiratory syncytial virus infection in elderly persons","volume":"189","author":"EE Walsh","year":"2004","journal-title":"J Infect Dis"},{"key":"pone.0264890.ref009","unstructured":"PATH Vaccine Resource Library. 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