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However, their interaction during the control of vascular function has not been fully clear. Here, we investigated the potential role of H<jats:sub>2<\/jats:sub>S in SO<jats:sub>2<\/jats:sub> production and vascular regulation <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Wistar rats were divided into the vehicle, SO<jats:sub>2<\/jats:sub>, DL-propargylglycine (PPG) + SO<jats:sub>2<\/jats:sub>, \u03b2-cyano-L-alanine (BCA) + SO<jats:sub>2<\/jats:sub> and sodium hydrosulfide (NaHS) + SO<jats:sub>2<\/jats:sub> groups. SO<jats:sub>2<\/jats:sub> donor was administered with or without pre-administration of PPG, BCA or NaHS for 30 min after blood pressure was stabilized for 1 h, and then, the change in blood pressure was detected by catheterization via the common carotid artery. Rat plasma SO<jats:sub>2<\/jats:sub> and H<jats:sub>2<\/jats:sub>S concentrations were measured by high performance liquid chromatography and sensitive sulfur electrode, respectively. The isolated aortic rings were prepared for the measurement of changes in vasorelaxation stimulated by SO<jats:sub>2<\/jats:sub> after PPG, BCA or NaHS pre-incubation. Results showed that the intravenous injection of SO<jats:sub>2<\/jats:sub> donors caused transient hypotension in rats compared with vehicle group. After PPG or BCA pretreatment, the plasma H<jats:sub>2<\/jats:sub>S content decreased but the SO<jats:sub>2<\/jats:sub> content increased markedly, and the hypotensive effect of SO<jats:sub>2<\/jats:sub> was significantly enhanced. Conversely, NaHS pretreatment upregulated the plasma H<jats:sub>2<\/jats:sub>S content but reduced SO<jats:sub>2<\/jats:sub> content, and attenuated the hypotensive effect of SO<jats:sub>2<\/jats:sub>. After PPG or BCA pre-incubation, the vasorelaxation response to SO<jats:sub>2<\/jats:sub> was enhanced significantly. While NaHS pre-administration weakened the SO<jats:sub>2<\/jats:sub>-induced relaxation in aortic rings. In conclusion, our <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> data indicate that H<jats:sub>2<\/jats:sub>S negatively controls the plasma content of SO<jats:sub>2<\/jats:sub> and the vasorelaxant effect under physiological conditions.<\/jats:p>","DOI":"10.1371\/journal.pone.0264891","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T17:59:50Z","timestamp":1647539990000},"page":"e0264891","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Role of hydrogen sulfide in sulfur dioxide production and vascular 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