{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T17:07:24Z","timestamp":1747242444820,"version":"3.37.3"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006366","name":"Minist\u00e9rio da Educa\u00e7\u00e3o","doi-asserted-by":"publisher","award":["R$: 19.000,00"],"award-info":[{"award-number":["R$: 19.000,00"]}],"id":[{"id":"10.13039\/501100006366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the possible development of serious illness, and the possibility of severe obstetric outcomes highlight the importance of addressing SARS-CoV-2 infection in obstetric management.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods and findings<\/jats:title>\n<jats:p>A cross-sectional study of pregnant women assisted in a high-risk maternity hospital in Brazil in 2020. All patients admitted for delivery or miscarriage care were tested for SARS-CoV-2 using polymerase chain reaction (PCR) and for immunoglobulin (I)gM, and\/or IgG by immunochromatography. Clinical aspects and obstetric outcomes were analyzed. A total of 265 pregnant women were included in the study. There were 38 (14.4%) PCR positive cases during pregnancy, 12 (31.6%) on admission screening, and 71(27.2%) patients were IgM- and\/or IgG-positive. Among the participants, 86 (32.4%) had at least one positive test during pregnancy. SARS-CoV-2 positive patients had greater contact with known positive patients (p = 0.005). The most frequently reported symptoms were runny nose, cough, loss of smell and taste, headache, and fever. There was also a 35% rate of asymptomatic infections and a 4.6% rate of severe or critical infections. Patients exposed or infected with SARS-CoV-2 had a higher incidence of preterm delivery, cesarean section, need for resuscitation in the delivery room, Apgar score &lt;7 at 5 min, admission to the neonatal intensive care unit, and jaundice. Newborns with at least one positive test had a significantly greater need for phototherapy after delivery (p = 0.05). The results showed a high rate of positive tests among newborns (37.5%), which seems to be compatible with both neonatal and perinatal infection.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>It is important to further investigate SARS-CoV-2 infection during pregnancy, including the clinical course and the possibility of adverse outcomes with impact on maternal and fetal health, regardless of the development of symptoms.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0264901","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T18:23:05Z","timestamp":1647022985000},"page":"e0264901","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["SARS-CoV-2 infection in pregnant women assisted in a high-risk maternity hospital in Brazil: Clinical aspects and obstetric outcomes"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-0258","authenticated-orcid":true,"given":"Carolina Loyola Prest","family":"Ferrugini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neide Aparecida Tosato","family":"Boldrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco Luis Salume","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle Anne de Oliveira Batista","family":"Salgueiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamella Dunga de Paula","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-8379","authenticated-orcid":true,"given":"Angelica Espinosa","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"issue":"8","key":"pone.0264901.ref001","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A Novel Coronavirus from Patients with Pneumonia in China. 2019","volume":"382","author":"N Zhu","year":"2020","journal-title":"N Engl J Med"},{"issue":"22","key":"pone.0264901.ref002","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1056\/NEJMe2009758","article-title":"Asymptomatic Transmission, the Achilles\u2019 Heel of Current Strategies to Control Covid-19","volume":"382","author":"M Gandhi","year":"2020","journal-title":"N Engl J Med"},{"issue":"22","key":"pone.0264901.ref003","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1056\/NEJMc2009316","article-title":"Universal Screening for SARS-CoV-2 in Women Admitted for 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Available from: https:\/\/saude.es.gov.br\/Media\/sesa\/coronavirus\/Boletins\/Boletim%20Covid-19_01.pdf."},{"key":"pone.0264901.ref016","first-page":"2249","volume-title":"JAMA\u2014Journal of the American Medical Association","author":"N Sethuraman","year":"2020"},{"key":"pone.0264901.ref017","first-page":"1178","volume-title":"Clinical Microbiology and Infection","author":"G Caruana","year":"2020"},{"key":"pone.0264901.ref018","first-page":"e211050","article-title":"Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study","volume":"22","author":"J Villar","year":"2021","journal-title":"JAMA Pediatr"},{"issue":"6","key":"pone.0264901.ref019","doi-asserted-by":"crossref","first-page":"e759","DOI":"10.1016\/S2214-109X(21)00079-6","article-title":"Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis","volume":"9","author":"B Chmielewska","year":"2021","journal-title":"Lancet Glob Health"},{"issue":"4","key":"pone.0264901.ref020","doi-asserted-by":"crossref","first-page":"e217523","DOI":"10.1001\/jamanetworkopen.2021.7523","article-title":"Association of Maternal Perinatal SARS-CoV-2 Infection With Neonatal Outcomes During the COVID-19 Pandemic in Massachusetts","volume":"4","author":"A Angelidou","year":"2021","journal-title":"JAMA Netw Open"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0264901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T18:23:34Z","timestamp":1647023014000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0264901"}},"subtitle":[],"editor":[{"given":"Emma K.","family":"Kalk","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,11]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0264901","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2022,3,11]]}}}