{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T15:02:38Z","timestamp":1774796558919,"version":"3.50.1"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012050","name":"Noble Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Nonhost disease resistance is the most common type of plant defense mechanism against potential pathogens. In the present study, the metabolic enzyme formate dehydrogenase 1 (FDH1) was identified to associate with nonhost disease resistance in <jats:italic>Nicotiana benthamiana<\/jats:italic> and <jats:italic>Arabidopsis thaliana<\/jats:italic>. In Arabidopsis, <jats:italic>AtFDH1<\/jats:italic> was highly upregulated in response to both host and nonhost bacterial pathogens. The <jats:italic>Atfdh1<\/jats:italic> mutants were compromised in nonhost resistance, basal resistance, and gene-for-gene resistance. The expression patterns of salicylic acid (SA) and jasmonic acid (JA) marker genes after pathogen infections in <jats:italic>Atfdh1<\/jats:italic> mutant indicated that both SA and JA are involved in the <jats:italic>FDH1<\/jats:italic>-mediated plant defense response to both host and nonhost bacterial pathogens. Previous studies reported that FDH1 localizes to mitochondria, or both mitochondria and chloroplasts. Our results showed that the AtFDH1 mainly localized to mitochondria, and the expression level of FDH1 was drastically increased upon infection with host or nonhost pathogens. Furthermore, we identified the potential co-localization of mitochondria expressing FDH1 with chloroplasts after the infection with nonhost pathogens in Arabidopsis. This finding suggests the possible role of FDH1 in mitochondria and chloroplasts during defense responses against bacterial pathogens in plants.<\/jats:p>","DOI":"10.1371\/journal.pone.0264917","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T17:26:32Z","timestamp":1653067592000},"page":"e0264917","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Functional role of formate dehydrogenase 1 (FDH1) for host and nonhost disease resistance against bacterial pathogens"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-8014","authenticated-orcid":true,"given":"Seonghee","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramu S.","family":"Vemanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunhee","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemencia M.","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3230-9753","authenticated-orcid":true,"given":"Youngjae","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amita","family":"Kaundal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taegun","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Kyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1502-1659","authenticated-orcid":true,"given":"Muthappa","family":"Senthil-Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirankumar S.","family":"Mysore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"issue":"4","key":"pone.0264917.ref001","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1469-8137.2009.02849.x","article-title":"Nonhost and basal resistance: how to explain specificity?","volume":"182","author":"RE Niks","year":"2009","journal-title":"New Phytol"},{"key":"pone.0264917.ref002","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev-phyto-082712-102319","article-title":"Nonhost resistance against bacterial pathogens: retrospectives and prospects","volume":"51","author":"M Senthil-Kumar","year":"2013","journal-title":"Annu Rev Phytopathol"},{"issue":"5","key":"pone.0264917.ref003","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1094\/PHYTO-11-14-0298-RVW","article-title":"Host versus nonhost resistance: distinct wars with similar arsenals","volume":"105","author":"US Gill","year":"2015","journal-title":"Phytopathology"},{"issue":"1","key":"pone.0264917.ref004","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1094\/MPMI-23-1-0091","article-title":"Basal host resistance of barley to powdery mildew: connecting quantitative trait Loci and candidate genes","volume":"23","author":"R Aghnoum","year":"2010","journal-title":"Mol Plant-Microbe Interact"},{"key":"pone.0264917.ref005","first-page":"997","article-title":"Mini Review: Potential applications of non-host resistance for crop improvement","volume":"7","author":"S Lee","year":"2016","journal-title":"Front Plant Sci"},{"issue":"5","key":"pone.0264917.ref006","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00122-018-3055-0","article-title":"Mapping resistance to powdery mildew in barley reveals a large-effect nonhost resistance QTL","volume":"131","author":"CCT Romero","year":"2018","journal-title":"Theor Appl Genet"},{"key":"pone.0264917.ref007","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.plantsci.2018.07.002","article-title":"Genes involved in nonhost disease resistance as a key to engineer durable resistance in crops","volume":"279","author":"JP Fonseca","year":"2019","journal-title":"Plant Sci"},{"key":"pone.0264917.ref008","doi-asserted-by":"crossref","first-page":"100260","DOI":"10.1016\/j.plgene.2020.100260","article-title":"Analysis of QTL Bw1 and marker CAMS451 associated with the bacterial wilt resistance in hot pepper (Capsicum annuum L.)","volume":"24","author":"D. 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