{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:39:45Z","timestamp":1754397585419,"version":"3.40.5"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"crossref","award":["Fondo FORDECYT-PRONACES"],"award-info":[{"award-number":["Fondo FORDECYT-PRONACES"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mexican Government","award":["Programa Presupuestal P016; Anexo 13 del Decreto del Presupuesto de Egresos de la Federaci\u00f3n"],"award-info":[{"award-number":["Programa Presupuestal P016; Anexo 13 del Decreto del Presupuesto de Egresos de la Federaci\u00f3n"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>We performed a longitudinal SARS-CoV-2 seroepidemiological study in healthcare personnel of the two largest tertiary COVID-19 referral hospitals in Mexico City.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>All healthcare personnel, including staff physicians, physicians in training, nurses, laboratory technicians, researchers, students, housekeeping, maintenance, security, and administrative staff were invited to voluntarily participate, after written informed consent. Participants answered a computer-assisted self-administered interview and donated blood samples for antibody testing every three weeks from October 2020 to June 2021.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 883 participants (out of 3639 registered employees) contributed with at least one blood sample. The median age was 36 years (interquartile range: 28\u201346) and 70% were women. The most common occupations were nurse (28%), physician (24%), and administrative staff (22%). Two hundred and ninety participants (32.8%) had a positive-test result in any of the visits, yielding an overall adjusted prevalence of 33.5% for the whole study-period. Two hundred and thirty-five positive tests were identified at the baseline visit (prevalent cases), the remaining 55 positive tests were incident cases. Prevalent cases showed associations with both occupational (institution 2 vs. 1: adjusted odds ratio [aOR] = 2.24, 95% confidence interval [CI]: 1.54\u20133.25; laboratory technician vs. physician: aOR = 4.38, 95% CI: 1.75\u201310.93) and community (municipality of residence Xochimilco vs. Tlalpan: aOR = 2.03, 95% CI: 1.09\u20133.79) risk-factors. The incidence rate was 3.0 cases per 100 person-months. Incident cases were associated with community-acquired risk, due to contact with suspect\/confirmed COVID-19 cases (HR = 2.45, 95% CI: 1.21\u20135.00).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>We observed that between October 2020 and June 2021, healthcare workers of the two largest tertiary COVID-19 referral centers in Mexico City had similar level of exposure to SARS-CoV-2 than the general population. Most variables associated with exposure in this setting pointed toward community rather than occupational risk. Our observations are consistent with successful occupational medicine programs for SARS-CoV-2 infection control in the participating institutions but suggest the need to strengthen mitigation strategies in the community.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0264964","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T18:05:21Z","timestamp":1647540321000},"page":"e0264964","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Seroepidemiology of SARS-CoV-2 in healthcare personnel working at the largest tertiary COVID-19 referral hospitals in Mexico City"],"prefix":"10.1371","volume":"17","author":[{"given":"Vanessa","family":"D\u00e1vila-Conn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maribel","family":"Soto-Nava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanink N.","family":"Caro-Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor E.","family":"Paz-Ju\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Garc\u00eda-Esparza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Tapia-Trejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa","family":"P\u00e9rez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo F.","family":"Belaunzar\u00e1n-Zamudio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Reyes-Ter\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan G.","family":"Sierra-Madero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Galindo-Fraga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3371-4248","authenticated-orcid":true,"given":"Santiago","family":"\u00c1vila-R\u00edos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"pone.0264964.ref001","unstructured":"Gobierno de M\u00e9xico. [COVID-19 in Mexico. General Information]. 2021 [July 2021]. Available from: https:\/\/datos.covid-19.conacyt.mx\/"},{"key":"pone.0264964.ref002","unstructured":"Instituto Nacional de Salud P\u00fablica. [Reflections on the COVID-19 response in Mexico and suggestions to face future challenges]. 2020 [July 2021]. Available from: https:\/\/www.insp.mx\/avisos\/recomendaciones-pandemia"},{"key":"pone.0264964.ref003","unstructured":"UCSF Institute for Global Health Sciences. Mexico\u2019s Response to COVID-19: A Case Study. 2021 [July 2021]. Available from: https:\/\/globalhealthsciences.ucsf.edu\/news\/mexicos-response-covid-19-case-study"},{"key":"pone.0264964.ref004","unstructured":"Gobierno de M\u00e9xico. [National Institutes of Health: Actions and programmes] [updated July 2021]. Available from: https:\/\/www.gob.mx\/insalud\/acciones-y-programas\/institutos-nacionales-de-salud-27376"},{"key":"pone.0264964.ref005","unstructured":"Gobieno de M\u00e9xico. [Reports on COVID-19 in Healthcare personnel in Mexico 2021] [July 2021]. Available from: https:\/\/www.gob.mx\/salud\/documentos\/informes-sobre-el-personal-de-salud-covid19-en-mexico-2021"},{"key":"pone.0264964.ref006","unstructured":"Instituto Nacional de Salud P\u00fablica. [Preliminary results of the COVID-19 National Health and Nutrition Survey]. 2020 [July 2021]. 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