{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:15:39Z","timestamp":1747196139503,"version":"3.40.5"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nierenstiftung"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Blood pressure is known to be increased in kidney donors following living-donor kidney transplantation. However, the physiological underpinnings of the blood-pressure increase following uninephrectomy remain unclear. We hypothesized that changes in sympathetic tone or in parasympathetic modulation of sinus node function are involved in the blood-pressure increase following experimental kidney-mass reduction.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>C57BL6N mice (6 to 11 per group) subjected to sham surgery (controls) or uninephrectomy with or without a one-week course of sodium chloride-enriched, taurine-deficient diet were studied. Uninephrectomized mice treated with a subcutaneous infusion of angiotensin-II over a period of one week were positive controls. A transfemoral aortic catheter with telemetry unit was implanted, readings of heart-rate and blood-pressure were recorded. Powerspectral analysis of heart rate and systolic blood pressure was performed to gain surrogate parameters of sympathetictone and parasympathetic modulation of sinus node function. Baroreflex sensitivity of heart rate was determined from awake, unrestrained mice using spontaneous baroreflex gain technique.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Systolic arterial blood pressure, heart rate and baroreflex sensitivity were not different in uninephrectomized mice when compared to controls. Parasympathetic modulation of sinus node function was less in uninephrectomized mice in comparison to controls. Uninephrectomized mice of the high-angiotensin-II model or of the high-salt and taurine-deficiency model had an increased systolic arterial blood pressure.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Uninephrectomy associated with less parasympathetic modulation of sinus node function. The combination of uninephrectomy, taurine-deficiency and high-salt intake led to arterial hypertension.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0265086","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T18:38:11Z","timestamp":1646851091000},"page":"e0265086","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Experimental uninephrectomy associates with less parasympathetic modulation of heart rate and facilitates sodium-dependent arterial hypertension"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9684-0618","authenticated-orcid":true,"given":"Rainer U.","family":"Pliquett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf P.","family":"Brandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"pone.0265086.ref001","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3389\/fphys.2020.00725","article-title":"Physiology and Pathophysiology of Compensatory Adaptations of a Solitary Functioning Kidney","volume":"11","author":"Z McArdle","year":"2020","journal-title":"Front Physiol"},{"key":"pone.0265086.ref002","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1111\/ajt.14713","article-title":"Hypertension after kidney donation: Incidence, predictors, and correlates","volume":"18","author":"OA Sanchez","year":"2018","journal-title":"Am J Transplant"},{"key":"pone.0265086.ref003","doi-asserted-by":"crossref","first-page":"185","DOI":"10.7326\/0003-4819-145-3-200608010-00006","article-title":"Meta-analysis: risk for hypertension in living kidney donors","volume":"145","author":"N Boudville","year":"2006","journal-title":"Ann Intern Med"},{"key":"pone.0265086.ref004","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1111\/j.1600-6143.2005.01037.x","article-title":"Long-term consequences of live kidney donation follow-up in 93% of living kidney donors in a single transplant center","volume":"5","author":"J Gossmann","year":"2005","journal-title":"Am J Transplant"},{"key":"pone.0265086.ref005","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1056\/NEJMoa1408932","article-title":"Gestational Hypertension and Preeclampsia in Living Kidney Donors","volume":"372","author":"AX Garg","year":"2015","journal-title":"N Engl J Med"},{"key":"pone.0265086.ref006","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.2169\/internalmedicine.55.7215","article-title":"The Effects of Unilateral Nephrectomy on Blood Pressure and Its Circadian Rhythm","volume":"55","author":"N Ohashi","year":"2016","journal-title":"Intern Med"},{"key":"pone.0265086.ref007","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1038\/s41598-020-58393-w","article-title":"5\/6 nephrectomy induces different renal, cardiac and vascular consequences in 129\/Sv and C57BL\/6JRj mice","volume":"10","author":"M Hamzaoui","year":"2020","journal-title":"Sci Rep"},{"key":"pone.0265086.ref008","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1046\/j.1523-1755.2002.00620.x","article-title":"Compensatory renal hypertrophy is mediated by a cell cycle-dependent mechanism","volume":"62","author":"B Liu","year":"2002","journal-title":"Kidney Int"},{"key":"pone.0265086.ref009","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1172\/JCI78945","article-title":"Phosphatidylinositol 3-kinase signaling determines kidney size","volume":"125","author":"JK Chen","year":"2015","journal-title":"J Clin Invest"},{"key":"pone.0265086.ref010","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1152\/ajpregu.2002.282.1.R19","article-title":"Endogenous angiotensin modulates PGE2-mediated release of substance P from renal mechanosensory nerve fibers","volume":"282","author":"UC Kopp","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"pone.0265086.ref011","doi-asserted-by":"crossref","first-page":"R396","DOI":"10.1152\/ajpregu.90741.2008","article-title":"A high-salt diet does not influence renal sympathetic nerve activity: a direct telemetric investigation","volume":"297","author":"FD McBryde","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"pone.0265086.ref012","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/HYPERTENSIONAHA.115.06624","article-title":"Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study","volume":"67","author":"Q Sun","year":"2016","journal-title":"Hypertension"},{"key":"pone.0265086.ref013","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1472-6793-14-4","article-title":"Sympathoactivation and rho-kinase-dependent baroreflex function in experimental renovascular hypertension with reduced kidney mass","volume":"14","author":"RU Pliquett","year":"2014","journal-title":"BMC Physiol"},{"key":"pone.0265086.ref014","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.ki.5001503","article-title":"Accelerated NaCl-induced hypertension in taurine-deficient rat: role of renal function","volume":"70","author":"MS Mozaffari","year":"2006","journal-title":"Kidney Int"},{"key":"pone.0265086.ref015","doi-asserted-by":"crossref","first-page":"R904","DOI":"10.1152\/ajpregu.00488.2006","article-title":"Optimal frequency ranges for extracting information on cardiovascular autonomic control from the blood pressure and pulse interval spectrograms in mice","volume":"292","author":"V Baudrie","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"pone.0265086.ref016","doi-asserted-by":"crossref","first-page":"R902","DOI":"10.1152\/ajpregu.00716.2006","article-title":"Power spectral analysis in mice: what are the appropriate frequency bands?","volume":"292","author":"HM Stauss","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"pone.0265086.ref017","unstructured":"Hemolab software downloaded from http:\/\/www.haraldstauss.com\/HemoLab\/HemoLab.php"},{"key":"pone.0265086.ref018","doi-asserted-by":"crossref","first-page":"R142","DOI":"10.1152\/ajpregu.00319.2007","article-title":"Applicability of recent methods used to estimate spontaneous baroreflex sensitivity to resting mice","volume":"294","author":"D Laude","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"pone.0265086.ref019","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00004872-200201000-00016","article-title":"Reduced spontaneous baroreceptor sensitivity in patients with renovascular hypertension","volume":"20","author":"SA Gao","year":"2002","journal-title":"J Hypertens"},{"key":"pone.0265086.ref020","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1161\/HYPERTENSIONAHA.112.198499","article-title":"Long-term consequences of uninephrectomy in male and f1emale rats","volume":"60","author":"I Rodr\u00edguez-G\u00f3mez","year":"2012","journal-title":"Hypertension"},{"key":"pone.0265086.ref021","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1159\/000327586","article-title":"Uninephrectomy of diabetic OVE26 mice greatly accelerates albuminuria, fibrosis, inflammatory cell infiltration and changes in gene expression","volume":"119","author":"S Zheng","year":"2011","journal-title":"Nephron Exp Nephrol"},{"key":"pone.0265086.ref022","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1111\/jcmm.12438","article-title":"Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent","volume":"18","author":"CR Williams","year":"2014","journal-title":"J Cell Mol Med"},{"key":"pone.0265086.ref023","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2018.04.024","article-title":"Prevention of progression of diabetic nephropathy by the SGLT2 inhibitor ipragliflozin in uninephrectomized type 2 diabetic mice","volume":"830","author":"A Tahara","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"pone.0265086.ref024","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2012.09.030","article-title":"Measurement of F2- isoprostanes and isofurans using gas chromatography-mass spectrometry","volume":"59","author":"GL Milne","year":"2013","journal-title":"Free Radic Biol Med"},{"issue":"9","key":"pone.0265086.ref025","doi-asserted-by":"crossref","first-page":"e202000089","DOI":"10.1002\/jbio.202000089","article-title":"The early effects of uninephrectomy on rat kidney metabolic state using optical imaging","volume":"13","author":"S Mehrvar","year":"2020","journal-title":"J Biophotonics"},{"key":"pone.0265086.ref026","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/ajh.2008.270","article-title":"Exercise training reduces sympathetic modulation on cardiovascular system and cardiac oxidative stress in spontaneously hypertensive rats","volume":"21","author":"M Bertagnolli","year":"2008","journal-title":"Am J Hypertens"},{"key":"pone.0265086.ref027","doi-asserted-by":"crossref","first-page":"e112394","DOI":"10.1371\/journal.pone.0112394","article-title":"The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity","volume":"9","author":"M Oelze","year":"2014","journal-title":"PLoS One"},{"key":"pone.0265086.ref028","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa2024816","article-title":"Dapagliflozin in Patients with Chronic Kidney Disease","volume":"383","author":"HJL Heerspink","year":"2020","journal-title":"N Engl J Med"},{"key":"pone.0265086.ref029","doi-asserted-by":"crossref","first-page":"e126241","DOI":"10.1172\/jci.insight.126241","article-title":"High dietary salt-induced dendritic cell activation underlies microbial dysbiosis-associated hypertension","volume":"5","author":"JF Ferguson","year":"2019","journal-title":"JCI Insight"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0265086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T18:38:39Z","timestamp":1646851119000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0265086"}},"subtitle":[],"editor":[{"given":"Jaap A.","family":"Joles","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0265086","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2022,3,9]]}}}