{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:15:44Z","timestamp":1747196144894,"version":"3.40.5"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This study aimed to evaluate the quality of low-dose-rate (LDR) prostate brachytherapy (BT) based on treatment-related dosimetric outcomes. Data of 100 patients treated using LDR BT with stranded seeds from November 2012 to November 2017 were collected. The prescription dose for the prostate was 145 Gy. The dose constraints for the preoperative plan were: V100% \u2265 95%, V150% \u2264 60%, V200% \u2264 20% for the prostate; V100% for rectum, \u2264 1 cc; and V200 Gy for urethra, 0.0 cc. Intraoperative real-time dose calculation and postoperative dose distribution analysis on days 0 and 30 were performed. Median dosimetric outcomes on days 0 and 30 respective were: V100% 92.28% and 92.23%, V200% 18.63% and 25.02%, and D90% 150.88 Gy and 151.46 Gy for the prostate; V100% for the rectum, 0.11 cc and 0.22 cc; and V200 Gy for the urethra, 0.00 cc and 0.00 cc, respectively. Twenty patients underwent additional seed implantation to compensate for insufficient dose coverage of the prostate. No loss or substantial migration of seeds or severe toxicity was reported. With stranded seed implantation and intraoperative optimization, appropriate dose delivery to the prostate without excessive dose to the organs at risk could be achieved.<\/jats:p>","DOI":"10.1371\/journal.pone.0265143","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T17:35:10Z","timestamp":1648661710000},"page":"e0265143","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dosimetric outcomes of preoperative treatment planning with intraoperative optimization using stranded seeds in prostate brachytherapy"],"prefix":"10.1371","volume":"17","author":[{"given":"Jason Joon Bock","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eungman","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Hoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4856-6305","authenticated-orcid":true,"given":"Jihun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2033-3967","authenticated-orcid":true,"given":"Kyung Hwan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Back","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwa Kyung","family":"Byun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5205-3775","authenticated-orcid":true,"given":"Jaeho","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"issue":"12","key":"pone.0265143.ref001","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1056\/NEJMoa074311","article-title":"Quality of life and satisfaction with outcome among prostate-cancer survivors","volume":"358","author":"MG Sanda","year":"2008","journal-title":"N Engl J Med"},{"issue":"3","key":"pone.0265143.ref002","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.brachy.2016.01.003","article-title":"Defining the value framework for prostate brachytherapy using patient-centered outcome metrics and time-driven activity-based costing","volume":"15","author":"NG Thaker","year":"2016","journal-title":"Brachytherapy"},{"issue":"4","key":"pone.0265143.ref003","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/bju.14021","article-title":"Quality of life after brachytherapy or bilateral nerve-sparing robot-assisted radical prostatectomy for prostate cancer: a prospective cohort","volume":"121","author":"P Blanchard","year":"2018","journal-title":"BJU Int"},{"key":"pone.0265143.ref004","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1748-717X-6-130","article-title":"Incidence of seed migration to the chest, abdomen, and pelvis after transperineal interstitial prostate brachytherapy with loose (125)I seeds","volume":"6","author":"A Sugawara","year":"2011","journal-title":"Radiat Oncol"},{"issue":"1","key":"pone.0265143.ref005","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brachy.2004.02.003","article-title":"Prostate brachytherapy seed migration and dosimetry: analysis of stranded sources and other potential predictive factors","volume":"3","author":"DB Fuller","year":"2004","journal-title":"Brachytherapy"},{"issue":"2","key":"pone.0265143.ref006","first-page":"397","article-title":"The use of linked seeds eliminates lung embolization following permanent seed implantation for prostate cancer. 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