{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:54:56Z","timestamp":1787756096750,"version":"build-2784847793"},"reference-count":78,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001736","name":"German-Israeli Foundation for Scientific Research and Development","doi-asserted-by":"publisher","award":["1432"],"award-info":[{"award-number":["1432"]}],"id":[{"id":"10.13039\/501100001736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001736","name":"German-Israeli Foundation for Scientific Research and Development","doi-asserted-by":"publisher","award":["1432"],"award-info":[{"award-number":["1432"]}],"id":[{"id":"10.13039\/501100001736","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nieders\u00e4chsisch-Israelische Forschungsf\u00f6rderung"},{"name":"Nieders\u00e4chsisch-Israelische Forschungsf\u00f6rderung"},{"name":"Deutsche Gesellschaft f\u00fcr Parodontologie CP GABA"},{"name":"Deutsche Gesellschaft f\u00fcr Parodontologie CP GABA"},{"name":"Deutsche Gesellschaft f\u00fcr Parodontologie CP GABA"},{"name":"Hannover Biomedical Research School"},{"name":"Hannover Biomedical Research School"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Periodontitis is one of the most common infectious diseases in humans. It is characterized by a chronic inflammation of the tooth-supporting tissue that results in bone loss. However, the role and source of the pro-inflammatory cytokine interleukin-17 (IL-17) and of the cells producing it locally in the gingiva is still controversial. Th17 \u03b1\u03b2 T cells, CD4<jats:sup>+<\/jats:sup> exFoxP3<jats:sup>+<\/jats:sup> \u03b1\u03b2 T cells, or IL-17-producing \u03b3\u03b4 T cells (\u03b3\u03b417 cells) seem to be decisive cellular players in periodontal inflammation. To address these issues in an experimental model for periodontitis, we employed genetic mouse models deficient for either \u03b3\u03b4 T cells or IL-17 cytokines and assessed the bone loss during experimental periodontal inflammation by stereomicroscopic, histological, and \u03bcCT-analysis. Furthermore, we performed flow-cytometric analyses and qPCR-analyses of the gingival tissue. We found no \u03b3\u03b4 T cell- or IL-17-dependent change in bone loss after four weeks of periodontitis. Apart from that, our data are complementary with earlier studies, which suggested IL-17-dependent aggravation of bone loss in early periodontitis, but a rather bone-protective role for IL-17 in late stages of experimental periodontitis with respect to the osteoclastogenicity defined by the RANKL\/OPG ratio.<\/jats:p>","DOI":"10.1371\/journal.pone.0265486","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T17:45:43Z","timestamp":1647539143000},"page":"e0265486","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Interleukin-17 is disease promoting in early stages and protective in late stages of experimental periodontitis"],"prefix":"10.1371","volume":"17","author":[{"given":"Anneke","family":"Wilharm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-4967","authenticated-orcid":true,"given":"Christoph","family":"Binz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Sandrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rampoldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Lienenklaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Blank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Winkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdi","family":"Demera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi-Hai","family":"Hovav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Stiesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immo","family":"Prinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"issue":"8","key":"pone.0265486.ref001","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1002\/eji.201343759","article-title":"Functional development of \u03b3\u03b4 T cells","volume":"43","author":"I Prinz","year":"2013","journal-title":"Eur J Immunol"},{"issue":"1","key":"pone.0265486.ref002","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cellimm.2015.04.007","article-title":"Evolution of two prototypic T cell lineages","volume":"296","author":"S Das","year":"2015","journal-title":"Cell Immunol"},{"key":"pone.0265486.ref003","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-immunol-032713-120216","article-title":"\u03b3\u03b4 T cells: First line of defense and beyond","volume":"32","author":"YH Chien","year":"2014","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"pone.0265486.ref004","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nri797","article-title":"\u03b3\u03b4 T cells: Functional plasticity and heterogeneity","volume":"2","author":"SR Carding","year":"2002","journal-title":"Nat Rev 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of infection","author":"WD Miller","year":"1891","journal-title":"In: Lancet"},{"issue":"5","key":"pone.0265486.ref018","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ahj.2007.06.037","article-title":"The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: A meta-analysis","volume":"154","author":"AA Bahekar","year":"2007","journal-title":"Am Heart J"},{"issue":"2","key":"pone.0265486.ref019","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/mi.2011.66","article-title":"Periodontitis, Porphyromonas, and the pathogenesis of rheumatoid arthritis.","volume":"5","author":"D Farquharson","year":"2012","journal-title":"Mucosal Immunol"},{"issue":"369","key":"pone.0265486.ref020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.aaj1921","article-title":"Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid 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interleukin-17s","volume":"62","author":"G Matsuzaki","year":"2018","journal-title":"Microbiol Immunol"},{"issue":"9","key":"pone.0265486.ref030","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23\/IL-17 Axis","volume":"182","author":"L van der Fits","year":"2009","journal-title":"J Immunol"},{"issue":"5","key":"pone.0265486.ref031","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.4049\/jimmunol.181.5.3456","article-title":"IL-17A Produced by \u03b3\u03b4 T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver","volume":"181","author":"S Hamada","year":"2008","journal-title":"J Immunol"},{"issue":"7","key":"pone.0265486.ref032","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.4049\/jimmunol.177.7.4662","article-title":"IL-17 Production Is Dominated by \u03b3\u03b4 T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection","volume":"177","author":"E Lockhart","year":"2006","journal-title":"J Immunol"},{"issue":"5180","key":"pone.0265486.ref033","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1126\/science.7916481","article-title":"Regulation of IgE responses to inhaled antigen in mice by antigen-specific \u03b3\u03b4 T cells","volume":"265","author":"C McMenamin","year":"1994","journal-title":"Science"},{"issue":"1","key":"pone.0265486.ref034","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4049\/jimmunol.1601024","article-title":"IL-17\u2013Producing Innate and Pathogen-Specific Tissue Resident Memory \u03b3\u03b4 T Cells Expand in the Lungs of Bordetella pertussis\u2013Infected Mice","volume":"198","author":"A Misiak","year":"2017","journal-title":"J Immunol"},{"issue":"2","key":"pone.0265486.ref035","doi-asserted-by":"crossref","first-page":"931","DOI":"10.4049\/jimmunol.165.2.931","article-title":"Expression of toll-like receptor 2 on gamma delta T cells bearing invariant V gamma 6\/V delta 1 induced by Escherichia coli infection in mice","volume":"165","author":"Y Mokuno","year":"2000","journal-title":"J Immunol"},{"issue":"8","key":"pone.0265486.ref036","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.4049\/jimmunol.1303420","article-title":"Staphylococcus aureus Infection of Mice Expands a Population of Memory \u03b3\u03b4 T Cells That Are Protective against Subsequent Infection","volume":"192","author":"AG Murphy","year":"2014","journal-title":"J Immunol"},{"issue":"3","key":"pone.0265486.ref037","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/eji.200839120","article-title":"IL-17-producing \u03b3\u03b4 T cells","volume":"39","author":"R O\u2019Brien","year":"2009","journal-title":"Eur J Immunol"},{"issue":"30","key":"pone.0265486.ref038","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1073\/pnas.1600713113","article-title":"IL-17A-producing resident memory \u03b3\u03b4 T cells orchestrate the innate immune response to secondary oral Listeria monocytogenes infection","volume":"113","author":"PA Romagnoli","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pone.0265486.ref039","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.immuni.2013.06.015","article-title":"\u03b3\u03b4 T Cells Exhibit Multifunctional and Protective Memory in Intestinal Tissues","volume":"39","author":"BS Sheridan","year":"2013","journal-title":"Immunity"},{"issue":"7","key":"pone.0265486.ref040","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.4049\/jimmunol.178.7.4466","article-title":"Resident V\u03b41 + \u03b3\u03b4 T Cells Control Early Infiltration of Neutrophils after Escherichia coli Infection via IL-17 Production","volume":"178","author":"K Shibata","year":"2007","journal-title":"J Immunol"},{"issue":"6","key":"pone.0265486.ref041","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.4049\/jimmunol.178.6.3786","article-title":"IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Gu\u00e9rin Infection","volume":"178","author":"M Umemura","year":"2007","journal-title":"J Immunol"},{"issue":"6025","key":"pone.0265486.ref042","first-page":"65","article-title":"Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17","volume":"332","author":"P Anne","year":"2011","journal-title":"Immunity. 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Yoshiki","year":"2014","journal-title":"J Invest Dermatol"},{"issue":"12","key":"pone.0265486.ref046","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1084\/jem.20181439","article-title":"Genetic models reveal origin, persistence and nonredundant functions of IL-17-producing \u03b3\u03b4 T cells","volume":"215","author":"I Sandrock","year":"2018","journal-title":"J Exp Med"},{"issue":"7464","key":"pone.0265486.ref047","article-title":"IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+ V\u03b36+ \u03b3\u03b4T cells.","volume":"6","author":"A Akitsu","year":"2015","journal-title":"Nat Commun."},{"issue":"10","key":"pone.0265486.ref048","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1002\/art.39732","article-title":"Interleukin-23\u2013Dependent \u03b3\/\u03b4 T Cells Produce Interleukin-17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice.","volume":"68","author":"A Reinhardt","year":"2016","journal-title":"Arthritis Rheumatol."},{"issue":"8","key":"pone.0265486.ref049","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.4049\/jimmunol.179.8.5576","article-title":"Exacerbation of Collagen-Induced Arthritis by Oligoclonal, IL-17-Producing \u03b3\u03b4 T Cells","volume":"179","author":"CL Roark","year":"2007","journal-title":"J Immunol"},{"key":"pone.0265486.ref050","first-page":"7","article-title":"The emerging roles of gamma-delta T cells in tissue inflammation in experimental autoimmune encephalomyelitis","author":"S Malik","year":"2016","journal-title":"Front Immunol"},{"issue":"11","key":"pone.0265486.ref051","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.15252\/embr.201744200","article-title":"IL \u201023 drives differentiation of peripheral \u03b3\u03b417 T cells from adult bone marrow\u2010derived precursors","volume":"18","author":"PH Papotto","year":"2017","journal-title":"EMBO Rep"},{"issue":"3","key":"pone.0265486.ref052","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.immuni.2010.08.013","article-title":"\u03b3\u03b4 T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism.","volume":"33","author":"F Petermann","year":"2010","journal-title":"Immunity"},{"issue":"2","key":"pone.0265486.ref053","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.immuni.2009.08.001","article-title":"Interleukin-1 and IL-23 Induce Innate IL-17 Production from \u03b3\u03b4 T Cells, Amplifying Th17 Responses and Autoimmunity.","volume":"31","author":"CE Sutton","year":"2009","journal-title":"Immunity"},{"issue":"42","key":"pone.0265486.ref054","doi-asserted-by":"crossref","first-page":"10738","DOI":"10.1073\/pnas.1802320115","article-title":"Amphiregulin-producing \u03b3\u03b4 T cells are vital for safeguarding oral barrier immune homeostasis","volume":"115","author":"S Krishnan","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"pone.0265486.ref055","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1053\/j.gastro.2006.06.003","article-title":"Intraepithelial \u03b3\u03b4+ Lymphocytes Maintain the Integrity of Intestinal Epithelial Tight Junctions in Response to Infection","volume":"131","author":"JE Dalton","year":"2006","journal-title":"Gastroenterology"},{"issue":"5568","key":"pone.0265486.ref056","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.1069639","article-title":"A role for skin \u03b3\u03b4 T cells in wound repair","volume":"296","author":"JM Jameson","year":"2002","journal-title":"Science"},{"issue":"21","key":"pone.0265486.ref057","doi-asserted-by":"crossref","first-page":"8743","DOI":"10.1073\/pnas.1019574108","article-title":"\u0393\u03b4 Intraepithelial Lymphocytes Are Essential Mediators of Host-Microbial Homeostasis At the Intestinal Mucosal Surface","volume":"108","author":"AS Ismail","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"pone.0265486.ref058","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jim.2013.05.002","article-title":"Optimization of the ligature-induced periodontitis model in mice","volume":"394","author":"T Abe","year":"2013","journal-title":"J Immunol Methods"},{"issue":"3","key":"pone.0265486.ref059","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1902\/jop.2013.130225","article-title":"Evaluation of the Host Response in Various Models of Induced Periodontal Disease in Mice.","volume":"85","author":"RS de Molon","year":"2014","journal-title":"J Periodontol."},{"issue":"12","key":"pone.0265486.ref060","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0003-9969(94)90055-8","article-title":"Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice","volume":"39","author":"PJ Baker","year":"1994","journal-title":"Arch Oral Biol"},{"issue":"33","key":"pone.0265486.ref061","doi-asserted-by":"crossref","first-page":"22907","DOI":"10.1074\/jbc.274.33.22907","article-title":"Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase","volume":"274","author":"JM Halleen","year":"1999","journal-title":"J Biol Chem"},{"issue":"3","key":"pone.0265486.ref062","doi-asserted-by":"crossref","first-page":"E337","DOI":"10.1073\/pnas.1614926114","article-title":"GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa","volume":"114","author":"M Nassar","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"pone.0265486.ref063","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/stem.160229","article-title":"Tyro 3 receptor tyrosine kinase and its ligand, Gas6, stimulate the function of osteoclasts","volume":"16","author":"YS Nakamura","year":"1998","journal-title":"Stem Cells"},{"issue":"3","key":"pone.0265486.ref064","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.immuni.2005.01.011","article-title":"Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17","volume":"22","author":"MA Stark","year":"2005","journal-title":"Immunity"},{"issue":"12","key":"pone.0265486.ref065","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1056\/NEJMe1615654","article-title":"Breaking a Vicious Cycle","volume":"376","author":"K. Ley","year":"2017","journal-title":"N Engl J Med"},{"issue":"5","key":"pone.0265486.ref066","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"CN Serhan","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"pone.0265486.ref067","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/SHK.0000000000000358","article-title":"Gamma Delta T Cells Regulate Inflammatory Cell Infiltration of the Lung after Trauma-Hemorrhage","volume":"43","author":"M Rani","year":"2015","journal-title":"Shock"},{"issue":"6","key":"pone.0265486.ref068","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1128\/IAI.67.6.2804-2809.1999","article-title":"CD4+ T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice","volume":"67","author":"PJ Baker","year":"1999","journal-title":"Infect Immun"},{"key":"pone.0265486.ref069","first-page":"106","article-title":"Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection","author":"YTA Teng","year":"2000","journal-title":"J Clin Invest"},{"issue":"5","key":"pone.0265486.ref070","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/mi.2015.136","article-title":"Characterization of the human immune cell network at the gingival barrier","volume":"9","author":"N Dutzan","year":"2016","journal-title":"Mucosal Immunol"},{"issue":"1","key":"pone.0265486.ref071","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1902\/jop.2004.75.1.37","article-title":"Interleukin-11 and IL-17 and the pathogenesis of periodontal disease.","volume":"75","author":"RB Johnson","year":"2004","journal-title":"J Periodontol."},{"issue":"8","key":"pone.0265486.ref072","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1902\/jop.2007.060458","article-title":"Gingival concentrations of interleukin-23 and -17 at healthy sites and at sites of clinical attachment loss.","volume":"78","author":"SR Lester","year":"2007","journal-title":"J Periodontol."},{"issue":"7","key":"pone.0265486.ref073","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1902\/jop.2011.110482","article-title":"Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients.","volume":"83","author":"N Dutzan","year":"2012","journal-title":"J Periodontol."},{"issue":"4","key":"pone.0265486.ref074","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.it.2017.08.005","article-title":"Tissue-Specific Immunity at the Oral Mucosal Barrier","volume":"39","author":"NM Moutsopoulos","year":"2018","journal-title":"Trends Immunol"},{"issue":"1","key":"pone.0265486.ref075","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.immuni.2016.12.010","article-title":"On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier","volume":"46","author":"N Dutzan","year":"2017","journal-title":"Immunity"},{"issue":"8","key":"pone.0265486.ref076","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1111\/cmi.12127","article-title":"Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis","volume":"15","author":"C Zenobia","year":"2013","journal-title":"Cell Microbiol"},{"issue":"9","key":"pone.0265486.ref077","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/ni1371","article-title":"Visualization of the earliest steps of \u03b3\u03b4 T cell development in the adult thymus","volume":"7","author":"I Prinz","year":"2006","journal-title":"Nat Immunol"},{"issue":"3","key":"pone.0265486.ref078","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0092-8674(93)90112-4","article-title":"T cell receptor \u03b4 gene mutant mice: Independent generation of \u03b1\u03b2 T cells and programmed rearrangements of \u03b3\u03b4 TCR genes","volume":"72","author":"S Itohara","year":"1993","journal-title":"Cell"}],"container-title":["PLOS 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