{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:41:04Z","timestamp":1770961264957,"version":"3.50.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004054","name":"king abdulaziz university","doi-asserted-by":"publisher","award":["The project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah under grant No.(G56-247-1442). The authors, therefore, acknowledge with thanks DSR technical and financial support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funders had role in technical support and financially"],"award-info":[{"award-number":["The project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah under grant No.(G56-247-1442). The authors, therefore, acknowledge with thanks DSR technical and financial support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funders had role in technical support and financially"]}],"id":[{"id":"10.13039\/501100004054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The AIDS is a chronic disease and the researchers still exert their high efforts to reach the cure of HIV infection. The most common treatment is the antiretroviral therapy (cART) and the virus can be more effected if the patients stop using cART. The other problem is that the CD8+ T cells might be exhausted by persistent immune activation by cART. This paper introduces fractional-order into a mathematical model of HIV infection combining with stem cell therapy and control the infection by the immune system cells (CD8+ T cells). The paper introduced the numerical solutions for the mathematical model. The results show that the stem cell therapy with the activation of immune system cells might causes the cure for a HIV patient. This results are consistent with medical studies. Also, we proposed the effect of the fractional order (<jats:italic>\u03b1<\/jats:italic>) on the figures of the components.<\/jats:p>","DOI":"10.1371\/journal.pone.0265627","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T21:41:21Z","timestamp":1648158081000},"page":"e0265627","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["On fractional numerical simulation of HIV infection for CD8+ T-cells and its treatment"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9934-6949","authenticated-orcid":true,"given":"R. 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