{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:46:21Z","timestamp":1782459981585,"version":"3.54.5"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the apocrine gland bearing skin, presenting various stages of flexural skin pain, erythema, painful nodules, abscesses, sinuses, and fistulas. We aimed to assess serum vitamin D levels in patients with (HS) in Jordan. a cross-sectional comparative study conducted among 110 patients with HS and 110 matched controls, who didn\u2019t previously receive vitamin D therapy. Serum vitamin D was measured and classified into normal (&gt;30 ng\/ml), insufficient (20\u201330 ng\/ml), and low (&lt;20 ng\/ml). The mean age of the cases was 43.1 \u00b1 12.9 years and the mean disease duration was 19.4 months. The mean body mass index among patients with HS was 30 and about 34% of them were smokers. The mean Vitamin D level was 8.4 ng\/ml and all HS patients were vitamin D deficient. Patients of HS were more likely to have vitamin D deficiency compared to healthy controls. Most of the study subjects and particularly all of the patients with HS have low vitamin D levels. Smoking and high BMI, were associated with HS. We suggest the implementation standard public dietary recommendations of Vitamin D supplementation, smoking cessation, and weight reduction behaviors with further assessment of disease course among HS patients.<\/jats:p>","DOI":"10.1371\/journal.pone.0265672","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T17:26:12Z","timestamp":1647624372000},"page":"e0265672","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence of low vitamin D levels in patients with Hidradenitis suppurativa in Jordan: A comparative cross-sectional study"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8442-887X","authenticated-orcid":true,"given":"Khaled","family":"Seetan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batool","family":"Eldos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthanna","family":"Saraireh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Omari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Rubbai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Jayyusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Abu Jubran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"pone.0265672.ref001","first-page":"372","volume-title":"Mayo Clinic Proceedings","author":"V Vanchinathan","year":"2012"},{"key":"pone.0265672.ref002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms19061618","article-title":"Role of vitamin D beyond the skeletal function: A review of the molecular and clinical studies","volume":"19","author":"M Umar","year":"2018","journal-title":"Int J Mol Sci"},{"key":"pone.0265672.ref003","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4103\/0378-6323.159928","article-title":"Vitamin D and skin diseases: A review","volume":"81","author":"B Wadhwa","year":"2015","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"pone.0265672.ref004","first-page":"262","volume-title":"Actas Dermo-Sifiliograficas","author":"FJ Navarro-Trivi\u00f1o","year":"2019"},{"key":"pone.0265672.ref005","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline","author":"MF Holick","year":"2011","journal-title":"Journal of Clinical Endocrinology and Metabolism. 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