{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:37:18Z","timestamp":1784025438768,"version":"3.55.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015631","name":"Merck Canada Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015631","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005247","name":"University of British Columbia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004726","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004726","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Hepatitis C virus (HCV) education may be changing following the simplification of HCV treatment and emergence of direct acting antiviral (DAA). We aimed to characterize HCV knowledge among people who recently completed DAA therapy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The Per-SVR (Preservation of Sustained Virologic Response) is a prospective cohort of patients who achieved a sustained virologic response upon successful completion of DAA therapy. The per-SVR study provided the sampling frame of participants who completed a psychometrically validated 19-item HCV knowledge scale at cohort entry (n = 227). To score the questionnaire, for each correct response one point was awarded, with no point for incorrect response. We assessed mean HCV knowledge score in the overall sample and mutually exclusive populations: people who inject drug (PWID) (n = 71); people with co-occurring HIV (n = 23); PWID and co-occurring HIV (n = 29), and others (n = 104) Using a latent class analysis based on distal outcome, we identified unobserved subgroups and assessed HCV knowledge amongst them.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Total mean (SD) percent of correct responses were 83 (11) in the overall sample; 83 (10) in PWID; 79 (12) in people with co-occurring HIV; 81 (10) in PWID and co-occurring HIV, and 84 (11) in rest of the sample Three latent groups were identified: baby boomers who ever experienced homelessness (n = 126); women sex workers who ever experienced homelessness (n = 68); men who inject drug, ever experienced homelessness and had ever diagnosis of mental health disorders (n = 18). Mean percent of correct responses were 85 (8), 82 (11), 85 (10), in latent class 1, 2, and 3, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Patients successfully treated with DAAs had a high HCV knowledge. High knowledge and awareness of reinfection among complex patient groups often facing barriers to HCV care is encouraging and emphasizes the positive outcomes of universal access to treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0265811","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T17:35:10Z","timestamp":1648056910000},"page":"e0265811","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Knowledge of hepatitis C and awareness of reinfection risk among people who successfully completed direct acting antiviral therapy"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1929-729X","authenticated-orcid":true,"given":"Kiana","family":"Yazdani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-1564","authenticated-orcid":true,"given":"Katerina","family":"Dolguikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Shayegi-Nik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaughna","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7815-0725","authenticated-orcid":true,"given":"Jason","family":"Trigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-2250","authenticated-orcid":true,"given":"Sophia","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio S. G.","family":"Montaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Salters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"pone.0265811.ref001","first-page":"1333","article-title":"Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence","volume":"57","author":"K Mohd Hanafiah","year":"2013"},{"key":"pone.0265811.ref002","unstructured":"World Health Organization. 2019; Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-c."},{"key":"pone.0265811.ref003","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S2468-1253(16)30181-9","article-title":"Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling 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Reau"},{"key":"pone.0265811.ref017","doi-asserted-by":"crossref","first-page":"ofy173","DOI":"10.1093\/ofid\/ofy173","article-title":"Predictors of Missed Hepatitis C Intake Appointments and Failure to Establish Hepatitis C Care Among Patients Living With HIV","volume":"5","author":"ER Cachay","year":"2018","journal-title":"Open forum infectious diseases"},{"key":"pone.0265811.ref018","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12954-020-00409-9","article-title":"A qualitative study of perceived barriers to hepatitis C care among people who did not attend appointments in the non-urban US South","volume":"17","author":"JE Sherbuk","year":"2020","journal-title":"Harm reduction journal"},{"key":"pone.0265811.ref019","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1471-6712.2008.00668.x","article-title":"Increasing public awareness about hepatitis C: development and validation of the brief hepatitis C knowledge scale","volume":"23","author":"L Balfour","year":"2009","journal-title":"Scand J Caring Sci"},{"key":"pone.0265811.ref020","author":"TF Babor","year":"2001"},{"key":"pone.0265811.ref021","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0306-4603(82)90005-3","article-title":"The drug abuse screening test","volume":"7","author":"HA Skinner","year":"1982","journal-title":"Addict Behav"},{"key":"pone.0265811.ref022","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jsat.2006.08.002","article-title":"A comprehensive review of the psychometric properties of the Drug Abuse Screening Test","volume":"32","author":"E Yudko","year":"2007","journal-title":"J Subst Abuse Treat"},{"key":"pone.0265811.ref023","first-page":"691","volume-title":"Handbook of psychology","author":"ST Lanza","year":"2013","edition":"2"},{"key":"pone.0265811.ref024","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijid.2020.08.035","article-title":"Syndemic profiles of people living with hepatitis C virus 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Health"},{"key":"pone.0265811.ref028","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1080\/10826084.2021.1892142","article-title":"Acceptability and Effectiveness of Hepatitis C Care at Syringe Service Programs for People Who Inject Drugs in New York City","volume":"56","author":"B Muncan","year":"2021","journal-title":"Subst Use Misuse"},{"key":"pone.0265811.ref029","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.drugpo.2017.02.006","article-title":"Knowledge of hepatitis C and treatment willingness amongst people who inject drugs in an era of direct acting antivirals","volume":"47","author":"A Mah","year":"2017","journal-title":"The International journal on drug policy"},{"key":"pone.0265811.ref030","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/jvh.12095","article-title":"Knowledge and attitudes about hepatitis C virus (HCV) infection and its treatment in HCV mono-infected and HCV\/HIV co-infected adults","volume":"20","author":"EY Chen","year":"2013","journal-title":"J Viral Hepat"},{"key":"pone.0265811.ref031","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1080\/09540121.2018.1466984","article-title":"Knowledge about HIV, HBV and HCV modes of transmission among pregnant women in Nampula\u2014Mozambique.","volume":"30","author":"E Chaquisse","year":"2018","journal-title":"AIDS Care"},{"key":"pone.0265811.ref032","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/13548506.2016.1189582","article-title":"HCV knowledge among a sample of HCV positive Aboriginal Australians residing in New South Wales.","volume":"22","author":"H Wilson","year":"2017","journal-title":"Psychol Health Med"},{"key":"pone.0265811.ref033","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12906-020-02959-8","article-title":"Herbal medicine use among patients with viral and non-viral Hepatitis in Uganda: prevalence, patterns and related factors","volume":"20","author":"S Nsibirwa","year":"2020","journal-title":"BMC complementary medicine and therapies"},{"key":"pone.0265811.ref034","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1053\/j.gastro.2014.12.004","article-title":"Herbal Products and the Liver: A Review of Adverse Effects and Mechanisms","volume":"148","author":"LB Seeff","year":"2015","journal-title":"Gastroenterology"},{"key":"pone.0265811.ref035","first-page":"CD003183","article-title":"Medicinal herbs for hepatitis C virus infection.","author":"JP Liu","year":"2001","journal-title":"The Cochrane database of systematic reviews"},{"key":"pone.0265811.ref036","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.drugalcdep.2018.11.010","article-title":"Development, validation, and potential applications of the hepatitis C virus injection-risk knowledge scale (HCV-IRKS) among young opioid users in New York City","volume":"194","author":"K Quinn","year":"2019","journal-title":"Drug Alcohol 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