{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T17:04:28Z","timestamp":1768323868093,"version":"3.49.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the ministry of science and technology of china","award":["2009BAI82B02"],"award-info":[{"award-number":["2009BAI82B02"]}]},{"name":"the oasis scholar fund of shihezi university","award":["(no. LZXZ201023)"],"award-info":[{"award-number":["(no. LZXZ201023)"]}]},{"name":"Corps Achievement Transfer Project","award":["2018BA006"],"award-info":[{"award-number":["2018BA006"]}]},{"name":"CX Major Public Health Cancer Early Diagnosis and Early Treatment for Cancer Registration Project","award":["0305+KC0026"],"award-info":[{"award-number":["0305+KC0026"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Objectives<\/jats:title><jats:p>H. pylori (Hp) infection has been indicated in the pathogenesis of gastric diseases including gastric cancer (GC). This study aimed at exploring the relationships between Hp infection and gastric diseases including GC in a large dataset of routine patients undergoing gastroscopy.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>From November 2007 to December 2017, 70,534 first-time visiting patients aged 18\u201394 years with gastroscopic biopsies were histologically diagnosed and analyzed. Patients\u2019 data were entered twice in an Excel spreadsheet database and analyzed using the SPSS (version 22.0) software package and statistical significance was defined as P&lt;0.05 for all analyses.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>The first interesting observation was age-related twin-peak prevalence profiles (TPPs) for Hp infection, gastritis, and advanced diseases with different time spans (TS) between the first and second occurring peaks. Hp infection and gastritis had TPPs occurring at earlier ages than TPPs of gastric introepithelial neoplasia (GIN) and GC. More patients were clustered at the second occurring TPPs. The time spans (TS) from the first occurring peak of Hp infection to the first occurring peaks of other gastric diseases varied dramatically with 0\u20135 years for gastritis; 5\u201315 years for GINs, and 5\u201320 years for GC, respectively. The number of males with Hp infection and gastric diseases, excluding non-atrophic gastritis (NAG), was more than that of females (P&lt;0.001).<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>We have first observed age-related twin-peak prevalence profiles for Hp infection, gastritis, GIN, and GC, respectively, among a large population of patients undergoing gastroscopy. The second prevalence peak of GC is at ages of 70\u201374 years indicating that many GC patients would be missed during screening because the cut-off age for screening is 69 years old in China.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0265885","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T18:00:00Z","timestamp":1658426400000},"page":"e0265885","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Age-related twin-peak prevalence profiles of H. pylori infection, gastritis, GIN and gastric cancer: Analyses of 70,534 patients with gastroscopic biopsies"],"prefix":"10.1371","volume":"17","author":[{"given":"Meng Qing","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Hui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi Hang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1269-2211","authenticated-orcid":true,"given":"Wen Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"issue":"6","key":"pone.0265885.ref001","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"F Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"pone.0265885.ref002","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3322\/caac.21338","article-title":"Cancer statistics in China,2015","volume":"66","author":"W Chen","year":"2016","journal-title":"CA Cancer J Clin."},{"issue":"11","key":"pone.0265885.ref003","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/jjco\/hys151","article-title":"Recent development of gastric cancer prevention","volume":"42","author":"M Kato","year":"2012","journal-title":"Jpn J Clin Oncol"},{"issue":"7","key":"pone.0265885.ref004","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/jjco\/hyy077","article-title":"Update version of the Japanese Guidelines for Gastric Cancer Screening","volume":"48","author":"Systematic Review Group and Guideline Development Group for Gastric Cancer Screening Guidelines","year":"2018","journal-title":"Jpn J Clin Oncol"},{"issue":"11","key":"pone.0265885.ref005","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/s41395-018-0353-8","article-title":"OLGA Gastritis Staging for the Prediction of Gastric Cancer Risk: A Long-term Follow-up Study of 7436 Patients","volume":"113","author":"M Rugge","year":"2018","journal-title":"Am J Gastroenterol"},{"issue":"7924","key":"pone.0265885.ref006","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0140-6736(75)90498-5","article-title":"A model for gastric cancer epidemiology","volume":"2","author":"P Correa","year":"1975","journal-title":"Lancet"},{"issue":"1","key":"pone.0265885.ref007","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbcan.2017.11.003","article-title":"Genetic host factors in Helicobacter pylori-induced carcinogenesis: Emerging new paradigms","volume":"1869","author":"MC Mommersteeg","year":"2018","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"pone.0265885.ref008","first-page":"38","author":"SR Hamilton","year":"2000"},{"issue":"6","key":"pone.0265885.ref009","first-page":"343","article-title":"Gastric cancer mortality in a high incidence area: long-term follow-up of Helicobacter pylori-related precancerous lesions in the general population.","volume":"16","author":"M Boreiri","year":"2013","journal-title":"Arch Iran Med"},{"key":"pone.0265885.ref010","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chom.2011.10.003","article-title":"Microbiome and malignancy","volume":"10","author":"CS Plottel","year":"2011","journal-title":"Cell Host Microbe"},{"key":"pone.0265885.ref011","first-page":"1","article-title":"Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7\u201314 June 1994","volume":"61","year":"1994","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"issue":"4","key":"pone.0265885.ref012","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1053\/j.gastro.2020.11.017","article-title":"The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions","volume":"160","author":"MB Piazuelo","year":"2021","journal-title":"Gastroenterology"},{"issue":"12","key":"pone.0265885.ref013","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1136\/gutjnl-2020-322368","article-title":"Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus","volume":"69","author":"JM Liou","year":"2020","journal-title":"Gut"},{"key":"pone.0265885.ref014","article-title":"Atlas of endoscopic diagnosis and differential diagnosis: upper digestive tract[J]","author":"Yoshino Junji","year":"2003","journal-title":"Liaoning Science and Technology Press"},{"key":"pone.0265885.ref015","first-page":"717","article-title":"Study on simplified staining method of Helicobacter pylori in gastric biopsy specimens","volume":"45","author":"S Ootuka","year":"1996","journal-title":"The Japanese journal of medical technology"},{"issue":"7","key":"pone.0265885.ref016","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1046\/j.1365-2036.2002.01301.x","article-title":"Gastric mucosal atrophy: interobserver consistency using new criteria for classification and grading.","volume":"16","author":"M Rugge","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"pone.0265885.ref017","doi-asserted-by":"crossref","first-page":"h3867","DOI":"10.1136\/bmj.h3867","article-title":"Incidence of gastric cancer among patients with gastric precancerous lesions: observational cohort study in a low risk Western population","volume":"351","author":"H Song","year":"2015","journal-title":"BMJ"},{"issue":"10125","key":"pone.0265885.ref018","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(17)33326-3","article-title":"Global surveillance of trends in cancer survival 2000\u201314 (CONCORD-3): analysis of individual records for 37\u2008513\u2008025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries","volume":"391","author":"CONCORD Working Group","year":"2018","journal-title":"Lancet"},{"issue":"2","key":"pone.0265885.ref019","article-title":"National center for clinical medical research on digestive diseases (2017) Expert consensus opinion on early gastric cancer screening process in China","volume":"23","author":"Zhao Shen","year":"2018","journal-title":"Chin J Gastroenterol"},{"key":"pone.0265885.ref020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.canep.2017.12.013","article-title":"Productivity losses due to premature mortality from cancer in Brazil, Russia, India, China, and South Africa (BRICS): A population-based comparison","volume":"53","author":"A Pearce","year":"2018","journal-title":"Cancer Epidemiol"},{"key":"pone.0265885.ref021","author":"C Johnson","year":"2013","journal-title":"Eurasian Corridors of Interconnection\u2014From the South China to the Caspian Sea"},{"issue":"13","key":"pone.0265885.ref022","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.3748\/wjg.v19.i13.2092","article-title":"Missed diagnosis of early gastric cancer or high-grade intraepithelial neoplasia","volume":"19","author":"W Ren","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"9","key":"pone.0265885.ref023","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1136\/gut.31.9.977","article-title":"High grade dysplasia of the gastric mucosa: a marker for gastric carcinoma","volume":"31","author":"M Lansdown","year":"1990","journal-title":"Gut"},{"issue":"2","key":"pone.0265885.ref024","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00000478-200002000-00001","article-title":"Gastric dysplasia: the Padova international classification","volume":"24","author":"M Rugge","year":"2000","journal-title":"Am J Surg PatholFeb"},{"issue":"2","key":"pone.0265885.ref025","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/gutjnl-2017-314205","article-title":"Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota","volume":"67","author":"RM Ferreira","year":"2018","journal-title":"Gut"},{"issue":"1","key":"pone.0265885.ref026","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11596-020-2151-y","article-title":"Helicobacter pylori Infection Facilitates the Expression of Resistin-like Molecule Beta in Gastric Carcinoma and Precursor Lesions.","volume":"40","author":"HJ Li","year":"2020","journal-title":"Curr Med Sci"},{"issue":"8","key":"pone.0265885.ref027","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3760\/cma.j.issn.0366-6999.20132494","article-title":"Relationship of Helicobacter pylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study","volume":"127","author":"L Zhou","year":"2014","journal-title":"Chin Med J (Engl)."},{"issue":"5","key":"pone.0265885.ref028","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/gutjnl-2015-310846","article-title":"Chronicles of a cancer foretold: 35\u2005years of gastric cancer risk assessment","volume":"65","author":"M Rugge","year":"2016","journal-title":"Gut"},{"issue":"4","key":"pone.0265885.ref029","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cgh.2007.12.044","article-title":"Effect of eradication of Helicobacter pylori on the histology and cellular phenotype of gastric intestinal metaplasia","volume":"6","author":"J Watari","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"pone.0265885.ref030","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s10120-014-0411-x","article-title":"Age and sex interactions in gastric cancer incidence and mortality trends in Korea","volume":"18","author":"M Song","year":"2015","journal-title":"Gastric Cancer"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0265885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T16:14:35Z","timestamp":1727626475000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0265885"}},"subtitle":[],"editor":[{"given":"Sanjiv","family":"Mahadeva","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0265885","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,21]]}}}