{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:56:36Z","timestamp":1776387396010,"version":"3.51.2"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Disturbed sleep can cause to m health problems such as cognitive impairment, depressed mood, and negative effects on cardiovascular, endocrine, and immune function. This study formulates and optimizes Eszopiclone trilaminate fast dissolving film.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Prepared Eszopiclone trilaminate fast dissolving film (Eszopiclone TFDF) was characterized by disintegration time, drug release, tensile strength (TS), percentage elongation (EB%), folding endurance, taste masking test, and <jats:italic>in vitro<\/jats:italic> dissolution test. The selected formulas were F2 (0.5% xanthan gum, 10% propylene glycol), F4 (3% sodium alginate, 10% propylene glycol) and F6 (1.5% pullulan, 10% propylene glycol) were subjected to <jats:italic>in vivo<\/jats:italic> study compared to conventional Lunesta\u00ae tablet.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The results indicated that disintegration time was in the range of 940 m. Drug release was found to be in the field of 78.51%\u201399.99%, while TS values and EB% differed from 11.12 to 25.74 (MPa) and 25.38%\u201336.43%, respectively. The folding endurance went between 200 and 300 times. All formulas exhibited acceptable uniformity content, surface <jats:bold>pH<\/jats:bold>, film thickness, and a good taste feeling.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>F4 had the highest C<jats:sub>max<\/jats:sub> (39.741 \u00b1 6.785-\u03bcg\/l) and lower T<jats:sub>max<\/jats:sub> (1.063 hr) among other formulas and conventional tablets. Therefore, FDFs\u2019 technology could increase the therapeutic effect of Eszopiclone.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0266019","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T17:42:30Z","timestamp":1654796550000},"page":"e0266019","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Construction of sublingual trilaminated Eszopiclone fast dissolving film for the treatment of Insomnia: Formulation, characterization and In vivo clinical comparative pharmacokinetic study in healthy human subjects"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7565-301X","authenticated-orcid":true,"given":"Mahmoud","family":"Teaima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Yasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehal","family":"Elfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-559X","authenticated-orcid":true,"given":"Kamel","family":"Shoueir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"El-Nabarawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa","family":"Helal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"issue":"4","key":"pone.0266019.ref001","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0022-3999(02)00309-4","article-title":"Depression and immune function: central pathways to morbidity and mortality","volume":"53","author":"J.K. 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