{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:37:33Z","timestamp":1768646253385,"version":"3.49.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>The coronavirus disease has become a global pandemic, and it continues to wreak havoc on global health and the economy. The development of vaccines may offer a potential eradication of COVID-19. This study evaluated the general knowledge, attitude, and perception of COVID-19 vaccines in the Pakistani population.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>A self-reporting e-survey and questionnaire-based survey from vaccination centers of different cities of Pakistan among 502 participants were conducted. The questionnaire comprised four sections inquiring demographics, vaccination status, and perception or attitude towards the vaccine. Univariate logistic regression was applied to predict the knowledge, attitude and behavior of participants.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>The mean age of participants was 50.8\u00b120.3 years. 53% of the participants have both doses of vaccine administered. Pain on the site of injection (49.8%) was the most common symptom, followed by asthenia (43.0%), muscle pain (29.5%), and swelling (24.5%) on the site of vaccine administration. Females complain of more symptoms than males. More severe symptoms were reported after the first dose of vaccine administration; these symptoms subsided within a week for most participants. Overall, the respondents have a positive attitude towards the vaccine. 47.4% are sure about the vaccine\u2019s efficacy, 48.6% said getting vaccinated was their own decision, and 79.9% also recommended others to get vaccinated.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>The study concluded that the Pakistani population has a positive attitude but inadequate knowledge towards COVID-19 vaccines. Immediate awareness and vaccination education programs should be conducted by the authorities to complete the mass vaccination schedule.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0266028","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T21:50:01Z","timestamp":1648158601000},"page":"e0266028","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Perceived risk and perceptions of COVID-19 vaccine: A survey among general public in Pakistan"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6797-4879","authenticated-orcid":true,"given":"Bilal Mahmood","family":"Beg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmood","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadaf","family":"Areej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arfa","family":"Majeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Adil","family":"Rasheed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Moin","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qurat-ul-Ain","family":"Shoaib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadaf","family":"Aroosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"issue":"2","key":"pone.0266028.ref001","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1001\/jama.2020.24865","article-title":"COVID-19 as the leading cause of death in the United States","volume":"325","author":"SH Woolf","year":"2021","journal-title":"Jama"},{"key":"pone.0266028.ref002","article-title":"The World Mortality Dataset: Tracking excess mortality across countries during the COVID-19 pandemic","author":"A Karlinsky","year":"2021","journal-title":"medRxiv"},{"issue":"1","key":"pone.0266028.ref003","first-page":"1","article-title":"Years of life lost to COVID-19 in 81 countries","volume":"11","author":"HP i Arolas","year":"2021","journal-title":"Scientific reports"},{"key":"pone.0266028.ref004","doi-asserted-by":"crossref","first-page":"644199","DOI":"10.3389\/fpubh.2021.644199","article-title":"Epidemiological and Clinical Characteristics of COVID-19: A Retrospective Multi-Center Study in Pakistan","volume":"9","author":"M Ahmad","year":"2021","journal-title":"Front Public Health"},{"key":"pone.0266028.ref005","first-page":"56","article-title":"Evaluation of immunomodulatory effects of lomefloxacin in mice","author":"A Majeed","year":"2021","journal-title":"Brazilian Journal of Pharmaceutical Sciences"},{"issue":"10277","key":"pone.0266028.ref006","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0140-6736(21)00432-3","article-title":"Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials","volume":"397","author":"M Voysey","year":"2021","journal-title":"Lancet"},{"issue":"4","key":"pone.0266028.ref007","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/trstmh\/traa025","article-title":"COVID-19: a fast evolving pandemic","volume":"114","author":"J. 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