{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:26:19Z","timestamp":1793229979380,"version":"4.5.0"},"reference-count":160,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is one of the most severe global pandemic due to its high pathogenicity and death rate starting from the end of 2019. Though there are some vaccines available against SAER-CoV-2 infections, we are worried about their effectiveness, due to its unstable sequence patterns. Therefore, beside vaccines, globally effective supporting drugs are also required for the treatment against SARS-CoV-2 infection. To explore commonly effective repurposable drugs for the treatment against different variants of coronavirus infections, in this article, an attempt was made to explore host genomic biomarkers guided repurposable drugs for SARS-CoV-1 infections and their validation with SARS-CoV-2 infections by using the integrated bioinformatics approaches. At first, we identified 138 differentially expressed genes (DEGs) between SARS-CoV-1 infected and control samples by analyzing high throughput gene-expression profiles to select drug target key receptors. Then we identified top-ranked 11 key DEGs (SMAD4, GSK3B, SIRT1, ATM, RIPK1, PRKACB, MED17, CCT2, BIRC3, ETS1 and TXN) as hub genes (HubGs) by protein-protein interaction (PPI) network analysis of DEGs highlighting their functions, pathways, regulators and linkage with other disease risks that may influence SARS-CoV-1 infections. The DEGs-set enrichment analysis significantly detected some crucial biological processes (immune response, regulation of angiogenesis, apoptotic process, cytokine production and programmed cell death, response to hypoxia and oxidative stress), molecular functions (transcription factor binding and oxidoreductase activity) and pathways (transcriptional mis-regulation in cancer, pathways in cancer, chemokine signaling pathway) that are associated with SARS-CoV-1 infections as well as SARS-CoV-2 infections by involving HubGs. The gene regulatory network (GRN) analysis detected some transcription factors (FOXC1, GATA2, YY1, FOXL1, TP53 and SRF) and micro-RNAs (hsa-mir-92a-3p, hsa-mir-155-5p, hsa-mir-106b-5p, hsa-mir-34a-5p and hsa-mir-19b-3p) as the key transcriptional and post- transcriptional regulators of HubGs, respectively. We also detected some chemicals (Valproic Acid, Cyclosporine, Copper Sulfate and arsenic trioxide) that may regulates HubGs. The disease-HubGs interaction analysis showed that our predicted HubGs are also associated with several other diseases including different types of lung diseases. Then we considered 11 HubGs mediated proteins and their regulatory 6 key TFs proteins as the drug target proteins (receptors) and performed their docking analysis with the SARS-CoV-2 3CL protease-guided top listed 90 anti-viral drugs out of 3410. We found Rapamycin, Tacrolimus, Torin-2, Radotinib, Danoprevir, Ivermectin and Daclatasvir as the top-ranked 7 candidate-drugs with respect to our proposed target proteins for the treatment against SARS-CoV-1 infections. Then, we validated these 7 candidate-drugs against the already published top-ranked 11 target proteins associated with SARS-CoV-2 infections by molecular docking simulation and found their significant binding affinity scores with our proposed candidate-drugs. Finally, we validated all of our findings by the literature review. Therefore, the proposed candidate-drugs might play a vital role for the treatment against different variants of SARS-CoV-2 infections with comorbidities, since the proposed HubGs are also associated with several comorbidities.<\/jats:p>","DOI":"10.1371\/journal.pone.0266124","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T17:49:48Z","timestamp":1649353788000},"page":"e0266124","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Identification of host transcriptome-guided repurposable drugs for SARS-CoV-1 infections and their validation with SARS-CoV-2 infections by using the integrated bioinformatics approaches"],"prefix":"10.1371","volume":"17","author":[{"given":"Fee Faysal","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Selim","family":"Reza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shahin","family":"Sarker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-1863","authenticated-orcid":true,"given":"Md. Samiul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Parvez","family":"Mosharaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohel","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3883-3396","authenticated-orcid":true,"given":"Md. Nurul Haque","family":"Mollah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"issue":"10","key":"pone.0266124.ref001","first-page":"1294","article-title":"SARS update.","volume":"168","author":"J Maskalyk","year":"2003","journal-title":"CMAJ"},{"key":"pone.0266124.ref002","unstructured":"World Health Organization. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. 2004. Available from: http:\/\/www.who.int\/csr\/sars\/country\/table2004_04_21\/en\/index.html."},{"issue":"25","key":"pone.0266124.ref003","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMra032498","article-title":"The severe acute respiratory syndrome","volume":"349","author":"JS Peiris","year":"2003","journal-title":"New England Journal of Medicine"},{"issue":"9","key":"pone.0266124.ref004","doi-asserted-by":"crossref","first-page":"662","DOI":"10.7326\/0003-4819-141-9-200411020-00006","article-title":"The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients","volume":"141","author":"GM Leung","year":"2004","journal-title":"Annals of internal medicine"},{"issue":"6937","key":"pone.0266124.ref005","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/423240a","article-title":"Koch\u2019s postulates fulfilled for SARS virus","volume":"423","author":"RA Fouchier","year":"2003","journal-title":"Nature"},{"issue":"3","key":"pone.0266124.ref006","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1001\/jama.290.3.367","article-title":"Critically ill patients with severe acute respiratory syndrome","volume":"290","author":"RA Fowler","year":"2003","journal-title":"Jama"},{"issue":"3","key":"pone.0266124.ref007","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1001\/jama.290.3.374","article-title":"Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome","volume":"290","author":"TW Lew","year":"2003","journal-title":"Jama"},{"issue":"4","key":"pone.0266124.ref008","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jmv.25681","article-title":"Emerging coronaviruses: genome structure, replication, and pathogenesis","volume":"92","author":"Y Chen","year":"2020","journal-title":"Journal of medical virology"},{"issue":"8","key":"pone.0266124.ref009","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019.","volume":"382","author":"China Novel Coronavirus Investigating and Research Team.","year":"2020","journal-title":"N Engl J Med"},{"issue":"7798","key":"pone.0266124.ref010","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"P Zhou","year":"2020","journal-title":"nature"},{"issue":"7798","key":"pone.0266124.ref011","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"F Wu","year":"2020","journal-title":"Nature"},{"issue":"4","key":"pone.0266124.ref012","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jmv.25688","article-title":"The 2019\u2010new coronavirus epidemic: evidence for virus evolution","volume":"92","author":"D Benvenuto","year":"2020","journal-title":"Journal of medical virology"},{"issue":"2","key":"pone.0266124.ref013","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3390\/v12020244","article-title":"Systematic comparison of two animal-to-human transmitted human coronaviruses: SARS-CoV-2 and SARS-CoV.","volume":"12","author":"J Xu","year":"2020","journal-title":"Viruses"},{"issue":"6965","key":"pone.0266124.ref014","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"W Li","year":"2003","journal-title":"Nature"},{"issue":"6485","key":"pone.0266124.ref015","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.abb2762","article-title":"Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2","volume":"367","author":"R Yan","year":"2020","journal-title":"Science"},{"issue":"2","key":"pone.0266124.ref016","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.micinf.2020.01.004","article-title":"transmissibility of 2019-nCoV\u2014a quick overview and comparison with other emerging viruses","volume":"22","author":"Chen J. 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(SARS-CoV-2) through a drug-target interaction deep learning model.","volume":"18","author":"BR Beck","year":"2020","journal-title":"Computational and structural biotechnology journal"},{"key":"pone.0266124.ref026","article-title":"Identification of Key Genes and Pathways in SARS-CoV-2 Infection using Bioinformatics Analysis.","author":"Z Wang","year":"2020"},{"key":"pone.0266124.ref027","article-title":"Identification of potential key genes for SARS-CoV-2 infected human bronchial organoids based on bioinformatics analysis.","author":"H Gu","year":"2020","journal-title":"bioRxiv"},{"key":"pone.0266124.ref028","article-title":"Identification of common key genes and pathways between Covid-19 and lung cancer by using protein-protein interaction network analysis.","author":"KS Nan","year":"2021","journal-title":"bioRxiv"},{"key":"pone.0266124.ref029","author":"H Gu","year":"2020","journal-title":"Identification of key genes and pathways in the hPSC-derived lungs infected by the 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2019-nCoV\/SARS-CoV-2","volume":"6","author":"Y Zhou","year":"2020","journal-title":"Cell discovery"},{"key":"pone.0266124.ref042","first-page":"1494","article-title":"In Silico prediction of molecular targets of Astragaloside IV for alleviation of COVID-19 Hyperinflammation by systems network pharmacology and Bioinformatic gene expression analysis","volume":"11","author":"C Ge","year":"2020","journal-title":"Frontiers in pharmacology"},{"key":"pone.0266124.ref043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07391102.2020.1850360","article-title":"Computational gene expression profiling in the exploration of biomarkers, non-coding functional RNAs and drug perturbagens for COVID-19","author":"S Aishwarya","year":"2020","journal-title":"Journal of Biomolecular Structure and Dynamics"},{"issue":"suppl 1","key":"pone.0266124.ref044","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.22207\/JPAM.14.SPL1.47","article-title":"A lung transcriptomic analysis for exploring host response in COVID-19.","volume":"14","author":"A Saxena","year":"2020","journal-title":"J Pure Appl Microbiol."},{"issue":"8","key":"pone.0266124.ref045","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1080\/03639045.2020.1788070","article-title":"Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19","volume":"46","author":"Q Tao","year":"2020","journal-title":"Drug development and industrial pharmacy"},{"issue":"13","key":"pone.0266124.ref046","first-page":"7497","article-title":"CXCL10 an important chemokine associated with cytokine storm in COVID-19 infected patients.","volume":"24","author":"N Zhang","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci."},{"issue":"D1","key":"pone.0266124.ref047","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets\u2014update","volume":"41","author":"T Barrett","year":"2012","journal-title":"Nucleic acids research"},{"issue":"1","key":"pone.0266124.ref048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2172-6-2","article-title":"Expression profile of immune response genes in patients with severe acute respiratory syndrome","volume":"6","author":"R Reghunathan","year":"2005","journal-title":"BMC immunology"},{"issue":"D1","key":"pone.0266124.ref049","doi-asserted-by":"crossref","first-page":"D1102","DOI":"10.1093\/nar\/gky1033","article-title":"PubChem 2019 update: improved access to chemical data","volume":"47","author":"S Kim","year":"2019","journal-title":"Nucleic acids research"},{"issue":"2","key":"pone.0266124.ref050","first-page":"1","article-title":"voom: Precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"CW Law","year":"2014","journal-title":"Genome biology"},{"issue":"19","key":"pone.0266124.ref051","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1093\/bioinformatics\/bty377","article-title":"canvasDesigner: a versatile interactive high-resolution scientific multi-panel visualization toolkit","volume":"34","author":"B Zhang","year":"2018","journal-title":"Bioinformatics"},{"issue":"10","key":"pone.0266124.ref052","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/pmic.201100563","article-title":"History of protein\u2013protein interactions: From egg\u2010white to complex networks","volume":"12","author":"P Braun","year":"2012","journal-title":"Proteomics"},{"key":"pone.0266124.ref053","first-page":"gkw937","article-title":"The STRING database in 2017: quality-controlled protein\u2013protein association networks, made broadly accessible.","author":"D Szklarczyk","year":"2016","journal-title":"Nucleic acids research"},{"issue":"6","key":"pone.0266124.ref054","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nprot.2015.052","article-title":"NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data","volume":"10","author":"J Xia","year":"2015","journal-title":"Nature protocols"},{"issue":"43","key":"pone.0266124.ref055","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"suppl_2","key":"pone.0266124.ref056","doi-asserted-by":"crossref","first-page":"W169","DOI":"10.1093\/nar\/gkm415","article-title":"DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists","volume":"35","author":"DW Huang","year":"2007","journal-title":"Nucleic acids research"},{"issue":"1","key":"pone.0266124.ref057","first-page":"1","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"EY Chen","year":"2013","journal-title":"BMC bioinformatics"},{"issue":"1","key":"pone.0266124.ref058","first-page":"1","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Y Zhou","year":"2019","journal-title":"Nature communications"},{"issue":"D1","key":"pone.0266124.ref059","doi-asserted-by":"crossref","first-page":"D260","DOI":"10.1093\/nar\/gkx1126","article-title":"JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework","volume":"46","author":"A Khan","year":"2018","journal-title":"Nucleic acids 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DisGeNET knowledge platform for disease genomics: 2019 update.","volume":"48","author":"J Pi\u00f1ero","year":"2020","journal-title":"Nucleic acids research"},{"issue":"9","key":"pone.0266124.ref064","doi-asserted-by":"crossref","first-page":"e74250","DOI":"10.1371\/journal.pone.0074250","article-title":"SurvExpress: an online biomarker validation tool and database for cancer gene expression data using survival analysis","volume":"8","author":"R Aguirre-Gamboa","year":"2013","journal-title":"PloS one"},{"issue":"2","key":"pone.0266124.ref065","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"O Trott","year":"2010","journal-title":"Journal of computational chemistry"},{"issue":"16","key":"pone.0266124.ref066","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"GM Morris","year":"2009","journal-title":"Journal of computational chemistry"},{"issue":"13","key":"pone.0266124.ref067","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"EF Pettersen","year":"2004","journal-title":"Journal of computational chemistry"},{"key":"pone.0266124.ref068","doi-asserted-by":"crossref","unstructured":"Visualizer DS. v4. 0.100. 13345. 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Crystallography"},{"issue":"W1","key":"pone.0266124.ref075","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"A Waterhouse","year":"2018","journal-title":"Nucleic acids research"},{"key":"pone.0266124.ref076","article-title":"Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.","author":"AK Rana","year":"2020","journal-title":"Cytokine & growth factor reviews"},{"issue":"8","key":"pone.0266124.ref077","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.1074\/jbc.M805747200","article-title":"Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication","volume":"284","author":"CH Wu","year":"2009","journal-title":"Journal of Biological Chemistry"},{"issue":"11","key":"pone.0266124.ref078","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.3390\/nu10111741","article-title":"Effects of resveratrol on the renin-angiotensin system in the aging kidney.","volume":"10","author":"I Jang","year":"2018","journal-title":"Nutrients"},{"issue":"3","key":"pone.0266124.ref079","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jmii.2020.04.015","article-title":"ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome.","volume":"53","author":"CA Devaux","year":"2020","journal-title":"Journal of Microbiology, Immunology and Infection."},{"issue":"1","key":"pone.0266124.ref080","first-page":"1","article-title":"Effective inhibition of MERS-CoV infection by resveratrol.","volume":"17","author":"SC Lin","year":"2017","journal-title":"BMC infectious diseases."},{"issue":"16","key":"pone.0266124.ref081","doi-asserted-by":"crossref","first-page":"e00197","DOI":"10.1128\/JVI.00197-19","article-title":"A yeast suppressor screen used to identify mammalian SIRT1 as a proviral factor for Middle East respiratory syndrome coronavirus replication","volume":"93","author":"S Weston","year":"2019","journal-title":"Journal of virology"},{"key":"pone.0266124.ref082","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3389\/fgene.2020.00641","article-title":"Neutrophils, crucial, or harmful immune cells involved in coronavirus infection: a bioinformatics study","volume":"11","author":"N Hemmat","year":"2020","journal-title":"Frontiers in Genetics"},{"issue":"6","key":"pone.0266124.ref083","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1074\/jbc.M708033200","article-title":"Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-\u03b2 signaling","volume":"283","author":"X Zhao","year":"2008","journal-title":"Journal of Biological Chemistry"},{"issue":"17","key":"pone.0266124.ref084","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1093\/emboj\/16.17.5353","article-title":"TGF\u2010\u03b2 receptor\u2010mediated signalling through Smad2, Smad3 and Smad4","volume":"16","author":"A Nakao","year":"1997","journal-title":"The EMBO journal"},{"key":"pone.0266124.ref085","doi-asserted-by":"crossref","first-page":"110548","DOI":"10.1016\/j.biopha.2020.110548","article-title":"SARS-CoV infection crosstalk with human host cell noncoding-RNA machinery: An in-silico approach.","volume":"130","author":"H Yousefi","year":"2020","journal-title":"Biomedicine & Pharmacotherapy."},{"issue":"1","key":"pone.0266124.ref086","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-019-2482-x","article-title":"Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study.","volume":"23","author":"MG Shashaty","year":"2019","journal-title":"Critical Care."},{"key":"pone.0266124.ref087","article-title":"RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury","author":"II Siempos","year":"2018","journal-title":"JCI insight"},{"issue":"1","key":"pone.0266124.ref088","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41420-020-00331-w","article-title":"The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications.","volume":"6","author":"NV Ivanisenko","year":"2020","journal-title":"Cell death discovery."},{"issue":"7","key":"pone.0266124.ref089","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1158\/2159-8290.CD-20-0559","article-title":"The landscape of human cancer proteins targeted by SARS-CoV-2.","volume":"10","author":"B Tutuncuoglu","year":"2020","journal-title":"Cancer discovery."},{"key":"pone.0266124.ref090","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mehy.2018.01.011","article-title":"Hypothesis: Is there a link between the immune response to Human Herpes Virus type 6\u0391 (HHV-6\u0391) infection and the interaction network (interactome) of the genes encoding the CTSS, PTX3, CHI3L1, Mx1, CXCL16, BIRC3 and BST2 proteins?.","volume":"112","author":"E. Rouka","year":"2018","journal-title":"Medical hypotheses"},{"issue":"12","key":"pone.0266124.ref091","doi-asserted-by":"crossref","first-page":"e0243270","DOI":"10.1371\/journal.pone.0243270","article-title":"The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1.","volume":"15","author":"AM Alsamman","year":"2020","journal-title":"PLoS One"},{"key":"pone.0266124.ref092","doi-asserted-by":"crossref","first-page":"110653","DOI":"10.1016\/j.biopha.2020.110653","article-title":"Candesartan could ameliorate the COVID-19 cytokine storm.","volume":"131","author":"AG Elkahloun","year":"2020","journal-title":"Biomedicine & Pharmacotherapy."},{"issue":"21","key":"pone.0266124.ref093","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1093\/bioinformatics\/btaa725","article-title":"Mechanistic insights into SARS-CoV-2 epidemic via revealing the features of SARS-CoV-2 coding proteins and host responses upon its infection","volume":"36","author":"S Qin","year":"2020","journal-title":"Bioinformatics"},{"issue":"7","key":"pone.0266124.ref094","doi-asserted-by":"crossref","first-page":"102571","DOI":"10.1016\/j.autrev.2020.102571","article-title":"Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies","volume":"19","author":"P Fagone","year":"2020","journal-title":"Autoimmunity reviews"},{"issue":"5","key":"pone.0266124.ref095","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1128\/JVI.80.5.2445-2452.2006","article-title":"Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function.","volume":"80","author":"Y Ariumi","year":"2006","journal-title":"Journal of virology"},{"issue":"4","key":"pone.0266124.ref096","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10048-018-0557-5","article-title":"Ataxia telangiectasia alters the ApoB and reelin pathway","volume":"19","author":"J Canet-Pons","year":"2018","journal-title":"neurogenetics"},{"key":"pone.0266124.ref097","doi-asserted-by":"crossref","first-page":"100980","DOI":"10.1016\/j.genrep.2020.100980","article-title":"Gene expression profiling of corona virus microarray datasets to identify crucial targets in COVID-19 patients.","volume":"22","author":"P Ramesh","year":"2021","journal-title":"Gene Reports."},{"key":"pone.0266124.ref098","doi-asserted-by":"crossref","first-page":"118096","DOI":"10.1016\/j.lfs.2020.118096","article-title":"Matrix metallopeptidase 9 as a host protein target of chloroquine and melatonin for immunoregulation in COVID-19: A network-based meta-analysis","volume":"257","author":"S Hazra","year":"2020","journal-title":"Life sciences"},{"issue":"SI-1","key":"pone.0266124.ref099","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3906\/biy-2005-115","article-title":"Integration of transcriptomic profile of SARS-CoV-2 infected normal human bronchial epi-thelial cells with metabolic and protein-protein interaction networks","volume":"44","author":"HU Karakurt","year":"2020","journal-title":"Turkish journal of biology"},{"issue":"9","key":"pone.0266124.ref100","doi-asserted-by":"crossref","first-page":"101526","DOI":"10.1016\/j.isci.2020.101526","article-title":"Integrative network biology framework elucidates molecular mechanisms of SARS-CoV-2 pathogenesis.","volume":"23","author":"N Kumar","year":"2020","journal-title":"Iscience"},{"issue":"4","key":"pone.0266124.ref101","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.dsx.2020.04.020","article-title":"Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response.","volume":"14","author":"I. Astuti","year":"2020","journal-title":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews."},{"key":"pone.0266124.ref102","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.3389\/fimmu.2020.01949","article-title":"Overview of immune response during SARS-CoV-2 infection: lessons from the past","volume":"11","author":"VK Shah","year":"2020","journal-title":"Frontiers in immunology"},{"key":"pone.0266124.ref103","first-page":"3432","article-title":"Interleukin-8 as a biomarker for disease prognosis of coronavirus disease-2019 patients","volume":"11","author":"L Li","year":"2021","journal-title":"Frontiers in immunology"},{"issue":"4","key":"pone.0266124.ref104","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jcv.2013.09.015","article-title":"Longitudinal analysis of leukocyte differentials in peripheral blood of patients with acute respiratory viral infections","volume":"58","author":"MT McClain","year":"2013","journal-title":"Journal of Clinical Virology"},{"issue":"7","key":"pone.0266124.ref105","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3390\/microorganisms9071438","article-title":"SARS-CoV-2 infection remodels the phenotype and promotes angiogenesis of primary human Lung endothelial cells","volume":"9","author":"F Caccuri","year":"2021","journal-title":"Microorganisms"},{"issue":"1","key":"pone.0266124.ref106","doi-asserted-by":"crossref","first-page":"e01324","DOI":"10.1128\/mSphere.01324-20","article-title":"Interplay of Antibody and Cytokine Production Reveals CXCL13 as a Potential Novel Biomarker of Lethal SARS-CoV-2 Infection.","volume":"6","author":"AM Horspool","year":"2021","journal-title":"Msphere"},{"issue":"6","key":"pone.0266124.ref107","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1161\/CIRCRESAHA.121.319117","article-title":"SARS-CoV-2 initiates programmed cell death in platelets","volume":"129","author":"M Koupenova","year":"2021","journal-title":"Circulation research"},{"issue":"3","key":"pone.0266124.ref108","doi-asserted-by":"crossref","first-page":"109020","DOI":"10.1016\/j.celrep.2021.109020","article-title":"Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells","volume":"35","author":"PA Wing","year":"2021","journal-title":"Cell reports"},{"issue":"12","key":"pone.0266124.ref109","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1038\/s41401-020-00554-8","article-title":"Hypoxia, HIF-1\u03b1, and COVID-19: from pathogenic factors to potential therapeutic targets.","volume":"41","author":"ZO Serebrovska","year":"2020","journal-title":"Acta Pharmacologica Sinica"},{"issue":"12","key":"pone.0266124.ref110","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1134\/S0006297920120068","article-title":"COVID-19 and oxidative stress","volume":"85","author":"BV Chernyak","year":"2020","journal-title":"Biochemistry (Moscow)."},{"key":"pone.0266124.ref111","doi-asserted-by":"crossref","first-page":"100853","DOI":"10.1016\/j.nmni.2021.100853","article-title":"Severe acute respiratory syndrome coronavirus 2 may exploit human transcription factors involved in retinoic acid and interferon-mediated response: a hypothesis supported by an in silico analysis.","volume":"41","author":"I di Bari","year":"2021","journal-title":"New Microbes and New Infections"},{"issue":"10","key":"pone.0266124.ref112","doi-asserted-by":"crossref","first-page":"e05010","DOI":"10.1016\/j.heliyon.2020.e05010","article-title":"A SARS-CoV-2 host infection model network based on genomic human Transcription Factors (TFs) depletion.","volume":"6","author":"M Chetta","year":"2020","journal-title":"Heliyon"},{"issue":"4","key":"pone.0266124.ref113","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41574-021-00481-6","article-title":"Effects of pancreatic SARS-CoV-2 infection identified","volume":"17","author":"A. Morris","year":"2021","journal-title":"Nature Reviews Endocrinology"},{"issue":"4","key":"pone.0266124.ref114","doi-asserted-by":"crossref","first-page":"618","DOI":"10.2215\/CJN.09440620","article-title":"Expression of CD147 and Cyclophilin A in Kidneys of Patients with COVID-19","volume":"16","author":"H Su","year":"2021","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"7","key":"pone.0266124.ref115","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000024321","article-title":"Novel signaling pathways regulate SARS-CoV and SARS-CoV-2 infectious disease.","volume":"100","author":"LC Cheng","year":"2021","journal-title":"Medicine"},{"key":"pone.0266124.ref116","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.csbj.2021.01.034","article-title":"Chemokines and chemokine receptors during COVID-19 infection","volume":"19","author":"BA Khalil","year":"2021","journal-title":"Computational and structural biotechnology journal"},{"issue":"2","key":"pone.0266124.ref117","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/bjh.13317","article-title":"Haematopoietic and immune defects associated with GATA2 mutation","volume":"169","author":"M Collin","year":"2015","journal-title":"British journal of haematology"},{"issue":"1","key":"pone.0266124.ref118","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3892\/or.2015.3969","article-title":"Inhibitory effects of forkhead box L1 gene on osteosarcoma growth through the induction of cell cycle arrest and apoptosis","volume":"34","author":"X Chen","year":"2015","journal-title":"Oncology reports"},{"issue":"13","key":"pone.0266124.ref119","doi-asserted-by":"crossref","first-page":"8947","DOI":"10.1074\/jbc.M113.503755","article-title":"The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins","volume":"289","author":"S Wei","year":"2014","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"pone.0266124.ref120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-017-3100-4","article-title":"The prognostic utility of the transcription factor SRF in docetaxel-resistant prostate cancer: in-vitro discovery and in-vivo validation","volume":"17","author":"DJ Lundon","year":"2017","journal-title":"BMC cancer"},{"issue":"2","key":"pone.0266124.ref121","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20170047","article-title":"Circulating endothelial microparticles and miR-92a in acute myocardial infarction","volume":"37","author":"Y Zhang","year":"2017","journal-title":"Bioscience Reports"},{"issue":"5824","key":"pone.0266124.ref122","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.1139253","article-title":"Requirement of bic\/microRNA-155 for normal immune function","volume":"316","author":"A Rodriguez","year":"2007","journal-title":"Science"},{"key":"pone.0266124.ref123","doi-asserted-by":"crossref","first-page":"e9369","DOI":"10.7717\/peerj.9369","article-title":"Computational analysis of microRNA-mediated interactions in SARS-CoV-2 infection.","volume":"8","author":"MD Demirci","year":"2020","journal-title":"PeerJ"},{"key":"pone.0266124.ref124","doi-asserted-by":"crossref","first-page":"109891","DOI":"10.1016\/j.mehy.2020.109891","article-title":"Immunopharmacological management of COVID-19: Potential therapeutic role of valproic acid.","volume":"143","author":"G Unal","year":"2020","journal-title":"Medical Hypotheses"},{"issue":"1","key":"pone.0266124.ref125","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jinf.2013.01.004","article-title":"Cyclosporine has a potential role in the treatment of SARS","volume":"67","author":"CD Russell","year":"2013","journal-title":"Journal of Infection"},{"key":"pone.0266124.ref126","article-title":"In search for effective and safe drugs against SARS-CoV-2: Part II] The role of selected salts and organometallics of copper, zinc, selenium, and iodine food supplements.","author":"MS Abdel-Mottaleb","year":"2020","journal-title":"ChemRxiv: Preprint."},{"key":"pone.0266124.ref127","doi-asserted-by":"crossref","first-page":"106353","DOI":"10.1016\/j.leukres.2020.106353","article-title":"Acute leukemia in the time of COVID-19.","volume":"92","author":"M Gavillet","year":"2020","journal-title":"Leukemia research."},{"issue":"6","key":"pone.0266124.ref128","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.dsx.2020.09.027","article-title":"Ivermectin in COVID-19: What do we know?.","volume":"14","author":"S Pandey","year":"2020","journal-title":"Diabetes & Metabolic Syndrome."},{"issue":"8","key":"pone.0266124.ref129","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1517\/13543784.2010.499121","article-title":"New inhibitors of the mammalian target of rapamycin signaling pathway for cancer","volume":"19","author":"S Albert","year":"2010","journal-title":"Expert opinion on investigational drugs"},{"key":"pone.0266124.ref130","doi-asserted-by":"crossref","first-page":"109282","DOI":"10.1016\/j.cbi.2020.109282","article-title":"Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19","volume":"6","author":"A Husain","year":"2020","journal-title":"Chemico-biological interactions"},{"issue":"1","key":"pone.0266124.ref131","first-page":"17","article-title":"Sirolimus is effective in relapsed\/refractory autoimmune cytopenias: results of a prospective multi-institutional trial","volume":"127","author":"KL Bride","year":"2016","journal-title":"Blood, The Journal of the American Society of Hematology."},{"issue":"5","key":"pone.0266124.ref132","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3390\/jcm9051473","article-title":"Highly conserved homotrimer cavity formed by the SARS-CoV-2 spike glycoprotein: a novel binding site","volume":"9","author":"U Kalathiya","year":"2020","journal-title":"Journal of clinical medicine"},{"issue":"2","key":"pone.0266124.ref133","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1128\/AAC.03659-14","article-title":"Antiviral potential of ERK\/MAPK and PI3K\/AKT\/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis","volume":"59","author":"J Kindrachuk","year":"2015","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"pone.0266124.ref134","author":"American Society of Health-System Pharmacists (Ashp)","year":"2020","journal-title":"Assessment of Evidence for COVID-19-Related Treatments."},{"issue":"8","key":"pone.0266124.ref135","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.18632\/aging.102988","article-title":"Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections.","volume":"12","author":"A Zhavoronkov","year":"2020","journal-title":"Aging (Albany NY)."},{"issue":"7816","key":"pone.0266124.ref136","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41586-020-2286-9","article-title":"A SARS-CoV-2 protein interaction map reveals targets for drug repurposing","volume":"583","author":"DE Gordon","year":"2020","journal-title":"Nature"},{"key":"pone.0266124.ref137","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.virusres.2019.02.011","article-title":"Drug repurposing for new, efficient, broad spectrum antivirals","volume":"264","author":"M Garc\u00eda-Serradilla","year":"2019","journal-title":"Virus research"},{"key":"pone.0266124.ref138","doi-asserted-by":"crossref","first-page":"e57555","DOI":"10.7554\/eLife.57555","article-title":"Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome.","volume":"9","author":"FL van de Veerdonk","year":"2020","journal-title":"Elife"},{"issue":"5","key":"pone.0266124.ref139","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jtho.2020.02.010","article-title":"Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer.","volume":"15","author":"S Tian","year":"2020","journal-title":"Journal of thoracic oncology"},{"key":"pone.0266124.ref140","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bjid.2020.06.005","article-title":"Calcineurin inhibitors revisited: A new paradigm for COVID-19?.","volume":"24","author":"R Hage","year":"2020","journal-title":"Brazilian Journal of Infectious Diseases"},{"issue":"1","key":"pone.0266124.ref141","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.virusres.2012.02.002","article-title":"Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506","volume":"165","author":"J Carbajo-Lozoya","year":"2012","journal-title":"Virus research"},{"key":"pone.0266124.ref142","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.3389\/fphar.2020.01333","article-title":"Immunosuppressive drugs and COVID-19: a review","volume":"11","author":"TS Schoot","year":"2020","journal-title":"Frontiers in pharmacology"},{"issue":"7","key":"pone.0266124.ref143","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1111\/ajt.15874","article-title":"Case report of COVID\u201019 in a kidney transplant recipient: does immunosuppression alter the clinical presentation?.","volume":"20","author":"E Guillen","year":"2020","journal-title":"American Journal of Transplantation"},{"issue":"11","key":"pone.0266124.ref144","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1111\/ajt.16250","article-title":"Cyclosporine and COVID\u201019: Risk or favorable?.","volume":"20","author":"NN Poulsen","year":"2020","journal-title":"American Journal of Transplantation"},{"issue":"10","key":"pone.0266124.ref145","doi-asserted-by":"crossref","first-page":"e1002331","DOI":"10.1371\/journal.ppat.1002331","article-title":"The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.","volume":"7","author":"S Pfefferle","year":"2011","journal-title":"PLoS pathogens."},{"key":"pone.0266124.ref146","doi-asserted-by":"crossref","first-page":"100765","DOI":"10.1016\/j.genrep.2020.100765","article-title":"mTOR inhibition and p53 activation, microRNAs: The possible therapy against pandemic COVID-19","volume":"20","author":"MJ Ramaiah","year":"2020","journal-title":"Gene reports"},{"issue":"20","key":"pone.0266124.ref147","doi-asserted-by":"crossref","first-page":"10034","DOI":"10.18632\/oncotarget.2490","article-title":"Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation","volume":"5","author":"C Simioni","year":"2014","journal-title":"Oncotarget"},{"key":"pone.0266124.ref148","doi-asserted-by":"crossref","first-page":"e1006635","DOI":"10.1371\/journal.ppat.1006635","article-title":"Influenza virus differentially activates mTORc1 and mTORc2 signaling to maximize late stage replication.","volume":"13","author":"SK Kuss-duerkop","year":"2017","journal-title":"PLoS Pathog."},{"issue":"1","key":"pone.0266124.ref149","doi-asserted-by":"crossref","first-page":"108940","DOI":"10.1016\/j.celrep.2021.108940","article-title":"Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication","volume":"35","author":"G Garcia","year":"2021","journal-title":"Cell reports"},{"issue":"48","key":"pone.0266124.ref150","doi-asserted-by":"crossref","first-page":"e23357","DOI":"10.1097\/MD.0000000000023357","article-title":"First clinical study using HCV protease inhibitor danoprevir to treat COVID-19 patients.","volume":"99","author":"H Chen","year":"2020","journal-title":"Medicine"},{"key":"pone.0266124.ref151","volume-title":"Atazanavir.","author":"J Choi","year":"2021"},{"key":"pone.0266124.ref152","article-title":"Virtual Screening based prediction of potential drugs for COVID-19","volume":"23","author":"T. Sekhar","year":"2020","journal-title":"Combinatorial Chemistry & High Throughput Screening"},{"key":"pone.0266124.ref153","unstructured":"World Hepatitis Alliance press release: Hepatitis C drugs may offer an inexpensive treatment option for COVID-19. 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