{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:36:32Z","timestamp":1792143392970,"version":"4.4.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/00859"],"award-info":[{"award-number":["PI17\/00859"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","award":["IISP57179"],"award-info":[{"award-number":["IISP57179"]}],"id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>People in their fifties with HIV are considered older adults, but they appear not to be a homogeneous group.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Objective<\/jats:title><jats:p>To evaluate the differences among older adults with HIV according to their chronological age and the year of HIV diagnosis.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Methods<\/jats:title><jats:p>Cross-sectional study of the FUNCFRAIL cohort. Patients 50 or over with HIV were included and were stratified by both chronological age and the year of HIV diagnosis: before 1996 (long-term HIV survivors [LTHS]) and after 1996. We recorded sociodemographic data, HIV-related factors, comorbidities, frailty, physical function, other geriatric syndromes, and quality of life (QOL).<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Results<\/jats:title><jats:p>We evaluated 801 patients. Of these, 24.7% were women, 47.0% were LTHS, and 14.7% were 65 or over. Of the 65 or over patients, 73% were diagnosed after 1996. Higher rates of comorbidities among LTHS were found, being the more prevalent: COPD, history of cancer, osteoarthritis, depression, and other psychiatric disorders while the more prevalent among the 65 or over patients were: hypertension, diabetes, dyslipidemia, cancer, and osteoarthritis. LTHS showed a significantly worse QOL. There were no differences by the year of HIV diagnosis regarding frailty and functional impairment (SPPB &lt;10) but they were more than twice as prevalent in the 65 or over patients compared to the other chronological age groups.<\/jats:p><\/jats:sec><jats:sec id=\"sec005\"><jats:title>Conclusions<\/jats:title><jats:p>A LTHS and a 65 or over person are both \u201colder adults with HIV,\u201d but their characteristics and requirements differ markedly. It is mandatory to design specific approaches focused on the real needs of the different profiles.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0266191","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T17:33:10Z","timestamp":1648661590000},"page":"e0266191","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Different profiles among older adults with HIV according to their chronological age and the year of HIV diagnosis: The FUNCFRAIL cohort study (GeSIDA 9817)"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-5382","authenticated-orcid":true,"given":"F\u00e1tima","family":"Bra\u00f1as","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00aa Jos\u00e9","family":"Galindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-7405","authenticated-orcid":true,"given":"Miguel","family":"Torralba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-0953","authenticated-orcid":true,"given":"Antonio","family":"Antela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Vergas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Dronda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4549-7749","authenticated-orcid":true,"given":"Carmen","family":"Busca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Machuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00aa Jes\u00fas","family":"Bustinduy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Cabello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"S\u00e1nchez-Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the FUNCFRAIL study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"issue":"9","key":"pone.0266191.ref001","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1089\/aid.2011.0377","article-title":"Definition of advanced age in HIV infection: Looking for an age cut-off","volume":"28","author":"JR Blanco","year":"2012","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"2","key":"pone.0266191.ref002","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/QAI.0000000000000556","article-title":"Geriatric syndromes in older HIV-infected adults","volume":"69","author":"M Greene","year":"2015","journal-title":"J Acquir Immune Defic Syndr"},{"key":"pone.0266191.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12877-018-0789-0","article-title":"The increasing burden and complexity of multi-morbidity and polypharmacy in geriatric HIV patients: a cross sectional","volume":"18","author":"G Guaraldi","year":"2018","journal-title":"BMC Geriatr"},{"issue":"3","key":"pone.0266191.ref004","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/COH.0000000000000677","article-title":"Frailty: the current challenge for aging people with HIV","volume":"16","author":"J Falutz","year":"2021","journal-title":"Curr Opin HIV AIDS"},{"key":"pone.0266191.ref005","unstructured":"UNAIDS. 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