{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:49:20Z","timestamp":1793137760500,"version":"4.5.0"},"reference-count":174,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p><jats:italic>Ralstonia solanacearum<\/jats:italic> causes bacterial wilt disease, leading to severe crop losses. Xylem sap from <jats:italic>R<\/jats:italic>. <jats:italic>solanacearum<\/jats:italic>-infected tomato is enriched in the disaccharide trehalose. Water-stressed plants also accumulate trehalose, which increases drought tolerance via abscisic acid (ABA) signaling. Because <jats:italic>R<\/jats:italic>. <jats:italic>solanacearum<\/jats:italic>-infected plants suffer reduced water flow, we hypothesized that bacterial wilt physiologically mimics drought stress, which trehalose could mitigate. We found that <jats:italic>R<\/jats:italic>. <jats:italic>solanacearum<\/jats:italic>-infected plants differentially expressed drought-associated genes, including those involved in ABA and trehalose metabolism, and had more ABA in xylem sap. Consistent with this, treating tomato roots with ABA reduced both stomatal conductance and stem colonization by <jats:italic>R<\/jats:italic>. <jats:italic>solanacearum<\/jats:italic>. Treating roots with trehalose increased xylem sap ABA and reduced plant water use by lowering stomatal conductance and temporarily improving water use efficiency. Trehalose treatment also upregulated expression of salicylic acid (SA)-dependent tomato defense genes; increased xylem sap levels of SA and other antimicrobial compounds; and increased bacterial wilt resistance of SA-insensitive <jats:italic>NahG<\/jats:italic> tomato plants. Additionally, trehalose treatment increased xylem concentrations of jasmonic acid and related oxylipins. Finally, trehalose-treated plants were substantially more resistant to bacterial wilt disease. Together, these data show that exogenous trehalose reduced both water stress and bacterial wilt disease and triggered systemic disease resistance, possibly through a Damage Associated Molecular Pattern (DAMP) response pathway. This suite of responses revealed unexpected linkages between plant responses to biotic and abiotic stress and suggested that <jats:italic>R<\/jats:italic>. <jats:italic>solanacearum-<\/jats:italic>infected plants increase trehalose to improve water use efficiency and increase wilt disease resistance. The pathogen may degrade trehalose to counter these efforts. Together, these results suggest that treating tomatoes with exogenous trehalose could be a practical strategy for bacterial wilt management.<\/jats:p>","DOI":"10.1371\/journal.pone.0266254","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T17:25:49Z","timestamp":1651080349000},"page":"e0266254","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Trehalose increases tomato drought tolerance, induces defenses, and increases resistance to bacterial wilt disease"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-6661","authenticated-orcid":true,"given":"April M.","family":"MacIntyre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerian","family":"Meline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Augustine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn J.","family":"Dye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corri D.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali S.","family":"Iyer-Pascuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Kolomiets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"McCulloh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5805-8000","authenticated-orcid":true,"given":"Caitilyn","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"pone.0266254.ref001","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/978-1-4020-4538-7_16","volume-title":"Plant-Associated Bacteria","author":"TP Denny","year":"2006"},{"issue":"6","key":"pone.0266254.ref002","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1364-3703.2012.00804.x","article-title":"Top 10 plant pathogenic bacteria in molecular plant pathology","volume":"13","author":"J Mansfield","year":"2012","journal-title":"Molecular Plant Pathology"},{"key":"pone.0266254.ref003","volume-title":"Bacterial Wilt Disease and the Ralstonia solanacearum Species Complex","author":"JG Elphinstone","year":"2005"},{"key":"pone.0266254.ref004","first-page":"267","article-title":"On the life of Ralstonia solanacearum, a destructive bacterial plant pathogen","author":"B \u00c1lvarez","year":"2010","journal-title":"Technology and Education Topics in Applied Mcrobiology and Microbial Biotechnology"},{"issue":"10","key":"pone.0266254.ref005","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1128\/JB.188.10.3697-3708.2006","article-title":"Chemotaxis is required for virulence and competitive fitness of the bacterial wilt pathogen Ralstonia solanacearum","volume":"188","author":"J Yao","year":"2006","journal-title":"J Bacteriol"},{"issue":"17","key":"pone.0266254.ref006","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1128\/JB.00398-07","article-title":"The plant pathogen Ralstonia solanacearum needs aerotaxis for normal biofilm formation and interactions with its tomato host","volume":"189","author":"J Yao","year":"2007","journal-title":"J Bacteriol"},{"issue":"12","key":"pone.0266254.ref007","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1128\/JB.183.12.3597-3605.2001","article-title":"Ralstonia solanacearum needs motility for invasive virulence on tomato","volume":"183","author":"J Tans-Kersten","year":"2001","journal-title":"J Bacteriol"},{"issue":"6","key":"pone.0266254.ref008","doi-asserted-by":"crossref","first-page":"e1005686","DOI":"10.1371\/journal.ppat.1005686","article-title":"Escaping underground Nets: Extracellular DNases degrade plant extracellular traps and contribute to virulence of the plant pathogenic bacterium Ralstonia solanacearum","volume":"12","author":"T Tran","year":"2016","journal-title":"PLOS Pathogens"},{"issue":"5","key":"pone.0266254.ref009","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00425-012-1694-y","article-title":"Deciphering the route of Ralstonia solanacearum colonization in Arabidopsis thaliana roots during a compatible interaction: focus at the plant cell wall","volume":"236","author":"C Digonnet","year":"2012","journal-title":"Planta"},{"issue":"12","key":"pone.0266254.ref010","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1094\/MPMI-18-1296","article-title":"Pyramiding unmarked deletions in Ralstonia solanacearum shows that secreted proteins in addition to plant cell-wall-degrading enzymes contribute to virulence","volume":"18","author":"H Liu","year":"2005","journal-title":"Molecular Plant-Microbe Interactions"},{"issue":"2","key":"pone.0266254.ref011","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1094\/MPMI-8-0241","article-title":"Microscopic studies of intercellular infection and protoxylem invasion of tomato roots by Pseudomonas solanacearum","volume":"8","author":"J Vasse","year":"1995","journal-title":"Molecular Plant-Microbe Interactions"},{"key":"pone.0266254.ref012","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.pbi.2014.05.002","article-title":"Opening the Ralstonia solanacearum type III effector tool box: insights into host cell subversion mechanisms","volume":"20","author":"L Deslandes","year":"2014","journal-title":"Current Opinion in Plant Biology"},{"issue":"11","key":"pone.0266254.ref013","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1111\/1462-2920.13446","article-title":"Extracellular DNases of Ralstonia solanacearum modulate biofilms and facilitate bacterial wilt virulence","volume":"18","author":"T Tran","year":"2016","journal-title":"Environmental Microbiology"},{"issue":"6","key":"pone.0266254.ref014","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/mpp.12335","article-title":"The vascular plant-pathogenic bacterium Ralstonia solanacearum produces biofilms required for its virulence on the surfaces of tomato cells adjacent to intercellular spaces","volume":"17","author":"Y Mori","year":"2016","journal-title":"Molecular Plant Pathology"},{"issue":"13","key":"pone.0266254.ref015","doi-asserted-by":"crossref","first-page":"8312","DOI":"10.1016\/S0021-9258(18)92977-7","article-title":"High heterogeneity of the exopolysaccharides of Pseudomonas solanacearum strain GMI1000 and the complete structure of the major polysaccharide","volume":"266","author":"G Orgambide","year":"1991","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"pone.0266254.ref016","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/1462-2920.14020","article-title":"Metabolomics of tomato xylem sap during bacterial wilt reveals Ralstonia solanacearum produces abundant putrescine, a metabolite that accelerates wilt disease","volume":"20","author":"TM Lowe-Power","year":"2018","journal-title":"Environmental Microbiology"},{"key":"pone.0266254.ref017","article-title":"Revisiting the source of wilt symptoms: X-ray microcomputed tomography provides direct evidence that Ralstonia biomass clogs xylem vessels","author":"B Ingel","year":"2021","journal-title":"bioRxiv"},{"issue":"3","key":"pone.0266254.ref018","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10658-010-9598-9","article-title":"Strain-specific alfalfa water stress induced by Xylella fastidiosa","volume":"127","author":"MP Daugherty","year":"2010","journal-title":"European Journal of Plant Pathology"},{"issue":"381","key":"pone.0266254.ref019","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/jxb\/erg046","article-title":"Interactive effects of water stress and xylem-limited bacterial infection on the water relations of a host vine","volume":"54","author":"AJ McElrone","year":"2003","journal-title":"Journal of Experimental Botany"},{"issue":"2","key":"pone.0266254.ref020","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.1365-3059.1998.00211.x","article-title":"Alterations in transpiration and stem vascular tissues of two maize cultivars under conditions of water stress and late wilt disease","volume":"47","author":"MF Abd El-Rahim","year":"1998","journal-title":"Plant Pathology"},{"key":"pone.0266254.ref021","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3389\/fpls.2016.00902","article-title":"Understanding the impact of drought on foliar and xylem invading bacterial pathogen stress in chickpea","volume":"7","author":"R Sinha","year":"2016","journal-title":"Frontiers in Plant Science"},{"issue":"333","key":"pone.0266254.ref022","article-title":"Concurrent drought stress and vascular pathogen infection induce common and distinct transcriptomic responses in chickpea","volume":"8","author":"R Sinha","year":"2017","journal-title":"Frontiers in Plant Science"},{"issue":"25","key":"pone.0266254.ref023","article-title":"Trehalose accumulation in rice plants confers high tolerance levels to different abiotic stresses","volume":"99","author":"AK Garg","year":"2002","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"pone.0266254.ref024","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s004250050069","article-title":"Expression of the yeast trehalose-6-phosphate synthase gene in transgenic tobacco plants: Pleiotropic phenotypes include drought tolerance","volume":"201","author":"C Romero","year":"1997","journal-title":"Planta"},{"issue":"3","key":"pone.0266254.ref025","first-page":"782","article-title":"Enhancement of the performance of cowpea plants grown under drought conditions via trehalose application","volume":"7","author":"MA Khater","year":"2018","journal-title":"Middle East Journal of Agriculture Research"},{"issue":"1","key":"pone.0266254.ref026","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.plantsci.2005.02.026","article-title":"Tomato abiotic stress enhanced tolerance by trehalose biosynthesis","volume":"169","author":"C Cortina","year":"2005","journal-title":"Plant Science"},{"issue":"2","key":"pone.0266254.ref027","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11240-012-0225-7","article-title":"Overexpression of a trehalose-6-phosphate synthase\/phosphatase fusion gene enhances tolerance and photosynthesis during drought and salt stress without growth aberrations in tomato","volume":"112","author":"JI Lyu","year":"2012","journal-title":"Plant Cell, Tissue and Organ Culture"},{"key":"pone.0266254.ref028","article-title":"Trehalose synthesis contributes to osmotic stress tolerance and virulence of the bacterial wilt pathogen Ralstonia solanacearum","author":"AM MacIntyre","year":"2019","journal-title":"Molecular Plant-Microbe Interactions"},{"issue":"4","key":"pone.0266254.ref029","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00114-12","article-title":"The in planta transcriptome of Ralstonia solanacearum: conserved physiological and virulence strategies during bacterial wilt of tomato","volume":"3","author":"JM Jacobs","year":"2012","journal-title":"MBio"},{"key":"pone.0266254.ref030","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.arplant.59.032607.092945","article-title":"Trehalose metabolism and signaling","volume":"59","author":"MJ Paul","year":"2008","journal-title":"Annu Rev Plant Biol"},{"issue":"10","key":"pone.0266254.ref031","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1744-7909.2008.00736.x","article-title":"Trehalose biosynthesis in response to abiotic stresses","volume":"50","author":"M Iordachescu","year":"2008","journal-title":"Journal of Integrative Plant Biology"},{"issue":"6","key":"pone.0266254.ref032","article-title":"Gene families and evolution of trehalose metabolism in plants","volume":"34","author":"JE Lunn","year":"2007","journal-title":"Functional Plant Biology"},{"issue":"4","key":"pone.0266254.ref033","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/tpj.12509","article-title":"Trehalose metabolism in plants","volume":"79","author":"JE Lunn","year":"2014","journal-title":"The Plant Journal"},{"issue":"3","key":"pone.0266254.ref034","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.pbi.2007.04.001","article-title":"Trehalose 6-phosphate","volume":"10","author":"M Paul","year":"2007","journal-title":"Current Opinion in Plant Biology"},{"issue":"2","key":"pone.0266254.ref035","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/mp\/ssp114","article-title":"A single active trehalose-6-P synthase (TPS) and a family of putative regulatory TPS-like proteins in Arabidopsis","volume":"3","author":"L Vandesteene","year":"2010","journal-title":"Molecular Plant"},{"issue":"2","key":"pone.0266254.ref036","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1104\/pp.112.201400","article-title":"Expansive evolution of the trehalose-6-phosphate phosphatase gene family in Arabidopsis","volume":"160","author":"L Vandesteene","year":"2012","journal-title":"Plant Physiology"},{"issue":"1","key":"pone.0266254.ref037","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/BJ20060083","article-title":"Sugar-induced increases in trehalose 6-phosphate are correlated with redox activation of ADP-glucose pyrophosphorylase and higher rates of starch synthesis in Arabidopsis thaliana","volume":"397","author":"JE Lunn","year":"2006","journal-title":"Biochem J"},{"issue":"31","key":"pone.0266254.ref038","doi-asserted-by":"crossref","first-page":"11118","DOI":"10.1073\/pnas.0503410102","article-title":"Trehalose 6-phosphate regulates starch synthesis via posttranslational redox activation of ADP-glucose pyrophosphorylase","volume":"102","author":"A Kolbe","year":"2005","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"9","key":"pone.0266254.ref039","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1093\/jxb\/err311","article-title":"Metabolism control over growth: a case for trehalose-6-phosphate in plants","volume":"63","author":"H Schluepmann","year":"2012","journal-title":"Journal of Experimental Botany"},{"issue":"11","key":"pone.0266254.ref040","doi-asserted-by":"crossref","first-page":"6849","DOI":"10.1073\/pnas.1132018100","article-title":"Trehalose 6-phosphate is indispensable for carbohydrate utilization and growth in Arabidopsis thaliana","volume":"100","author":"H Schluepmann","year":"2003","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"pone.0266254.ref041","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1104\/pp.17.01634","article-title":"The role of trehalose 6-phosphate in crop yield and resilience","volume":"177","author":"MJ Paul","year":"2018","journal-title":"Plant Physiology"},{"issue":"2","key":"pone.0266254.ref042","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00425-019-03195-2","article-title":"ABA signaling rather than ABA metabolism is involved in trehalose-induced drought tolerance in tomato plants","volume":"250","author":"W Yu","year":"2019","journal-title":"Planta"},{"issue":"5","key":"pone.0266254.ref043","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.tplants.2019.02.001","article-title":"Linking Autophagy to Abiotic and Biotic Stress Responses","volume":"24","author":"S Signorelli","year":"2019","journal-title":"Trends in Plant Science"},{"issue":"1","key":"pone.0266254.ref044","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/jipb.12899","article-title":"Abscisic acid dynamics, signaling, and functions in plants","volume":"62","author":"K Chen","year":"2020","journal-title":"Journal of Integrative Plant Biology"},{"issue":"1","key":"pone.0266254.ref045","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1399-3054.2005.00537.x","article-title":"Exogenous trehalose alters Arabidopsis transcripts involved in cell wall modification, abiotic stress, nitrogen metabolism, and plant defense","volume":"125","author":"H Bae","year":"2005","journal-title":"Physiologia Plantarum"},{"issue":"5","key":"pone.0266254.ref046","doi-asserted-by":"crossref","first-page":"e0217204","DOI":"10.1371\/journal.pone.0217204","article-title":"Physiological and transcriptomic analyses reveal the molecular networks of responses induced by exogenous trehalose in plant","volume":"14","author":"Y Shi","year":"2019","journal-title":"PLOS ONE"},{"issue":"9","key":"pone.0266254.ref047","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1093\/jxb\/erv095","article-title":"The dual nature of trehalose in citrus canker disease: a virulence factor for Xanthomonas citri subsp. citri and a trigger for plant defence responses","volume":"66","author":"A Piazza","year":"2015","journal-title":"Journal of Experimental Botany"},{"issue":"5","key":"pone.0266254.ref048","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3186\/jjphytopath.62.478","article-title":"Antibacterial activity of Validamycin A against Pseudomonas solanacearum and its efficacy against tomato bacterial wilt","volume":"62","author":"R Ishikawa","year":"1996","journal-title":"Annals of the Phytopathological Society of Japan"},{"issue":"10","key":"pone.0266254.ref049","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1094\/PHYTO-95-1209","article-title":"Foliar spray of Validamycin A or Validoxylamine A controls tomato Fusarium wilt","volume":"95","author":"R Ishikawa","year":"2005","journal-title":"Phytopathology"},{"issue":"12","key":"pone.0266254.ref050","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1094\/MPMI-08-20-0211-R","article-title":"Validamycin A induces broad-spectrum resistance involving salicylic acid and jasmonic acid\/ethylene signaling pathways","volume":"33","author":"C Bian","year":"2020","journal-title":"Molecular Plant-Microbe Interactions"},{"issue":"1176","key":"pone.0266254.ref051","article-title":"Virus-Induced Gene Silencing-based functional analyses revealed the involvement of several putative trehalose-6-phosphate synthase\/phosphatase genes in disease resistance against Botrytis cinerea and Pseudomonas syringae pv. tomato DC3000 in tomato","volume":"7","author":"H Zhang","year":"2016","journal-title":"Frontiers in Plant Science"},{"issue":"11","key":"pone.0266254.ref052","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S1360-1385(01)02125-2","article-title":"An unexpected plethora of trehalose biosynthesis genes in Arabidopsis thaliana","volume":"6","author":"B Leyman","year":"2001","journal-title":"Trends in Plant Science"},{"issue":"6312","key":"pone.0266254.ref053","doi-asserted-by":"crossref","first-page":"aag1550","DOI":"10.1126\/science.aag1550","article-title":"A transcription factor hierarchy defines an environmental stress response network","volume":"354","author":"L Song","year":"2016","journal-title":"Science"},{"issue":"1","key":"pone.0266254.ref054","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1186\/s12870-019-1982-9","article-title":"Physiological analysis and transcriptome sequencing reveal the effects of combined cold and drought on tomato leaf","volume":"19","author":"R Zhou","year":"2019","journal-title":"BMC Plant Biology"},{"issue":"3","key":"pone.0266254.ref055","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00425-014-2215-y","article-title":"Identification and phylogenetic analysis of late embryogenesis abundant proteins family in tomato (Solanum lycopersicum)","volume":"241","author":"J Cao","year":"2015","journal-title":"Planta"},{"issue":"1","key":"pone.0266254.ref056","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40659-018-0152-0","article-title":"Regulation of aquaporins in plants under stress","volume":"51","author":"R Kapilan","year":"2018","journal-title":"Biological Research"},{"issue":"4","key":"pone.0266254.ref057","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1094\/MPMI-08-17-0209-R","article-title":"Whole root transcriptomic analysis suggests a role for auxin pathways in resistance to Ralstonia solanacearum in tomato","volume":"31","author":"E French","year":"2018","journal-title":"Molecular Plant-Microbe Interactions"},{"issue":"7","key":"pone.0266254.ref058","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tplants.2010.04.006","article-title":"ABA perception and signalling","volume":"15","author":"AS Raghavendra","year":"2010","journal-title":"Trends in Plant Science"},{"issue":"11","key":"pone.0266254.ref059","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.tim.2018.06.002","article-title":"How Ralstonia solanacearum exploits and thrives in the flowing plant xylem environment","volume":"26","author":"TM Lowe-Power","year":"2018","journal-title":"Trends Microbiol"},{"key":"pone.0266254.ref060","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1073\/pnas.92.10.4106","article-title":"Signals involved in wound-induced proteinase inhibitor II gene expression in tomato and potato plants","volume":"92","author":"H Pe\u00f1a-Cort\u00e9s","year":"1995","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"4","key":"pone.0266254.ref061","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1046\/j.1365-313X.2003.01895.x","article-title":"Virulence systems of Pseudomonas syringae pv. tomato promote bacterial speck disease in tomato by targeting the jasmonate signaling pathway","volume":"36","author":"Y Zhao","year":"2003","journal-title":"The Plant Journal"},{"key":"pone.0266254.ref062","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1094\/MPMI.1997.10.5.624","article-title":"Two PR-1 genes from tomato are differentially regulated and reveal a novel mode of expression for a pathogenesis-related gene during the hypersensitive response and development","volume":"5","author":"P Tornero","year":"1997","journal-title":"Molecular Plant-Microbe Interactions"},{"issue":"3","key":"pone.0266254.ref063","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1104\/pp.105.059246","article-title":"Systemic acquired tolerance to virulent bacterial pathogens in tomato","volume":"138","author":"A Block","year":"2005","journal-title":"Plant Physiology"},{"issue":"3","key":"pone.0266254.ref064","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1104\/pp.89.3.945","article-title":"Identification of several Pathogenesis-Related proteins in tomato leaves inoculated with Cladosporium fulvum (syn. Fulvia fulva) as 1,3-\u03b2-glucanases and chitinases","volume":"89","author":"MHAJ Joosten","year":"1989","journal-title":"Plant Physiology"},{"key":"pone.0266254.ref065","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1094\/MPMI.2003.16.2.141","article-title":"Partial resistance of tomato to Phytophthora infestans is not dependent upon ethylene, jasmonic acid, or salicylic acid signaling pathways","volume":"2","author":"CD Smart","year":"2003","journal-title":"Molecular Plant-Microbe Interactions"},{"issue":"6","key":"pone.0266254.ref066","doi-asserted-by":"crossref","first-page":"e00875","DOI":"10.1128\/mBio.00875-13","article-title":"Ralstonia solanacearum requires PopS, an ancient AvrE-family effector, for virulence and to overcome salicylic acid-mediated defenses during tomato pathogenesis","volume":"4","author":"JM Jacobs","year":"2013","journal-title":"MBio"},{"key":"pone.0266254.ref067","first-page":"2009","article-title":"Ethylene and abscisic acid signaling pathways differentially influence tomato resistance to combined powdery mildew and salt stress","volume":"7","author":"C Kissoudis","year":"2016","journal-title":"Frontiers in Plant Science"},{"issue":"5","key":"pone.0266254.ref068","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S1369-5266(03)00092-X","article-title":"Regulatory network of gene expression in the drought and cold stress responses","volume":"6","author":"K Shinozaki","year":"2003","journal-title":"Current Opinion in Plant Biology"},{"issue":"1","key":"pone.0266254.ref069","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF00279525","article-title":"The plant hormone abscisic acid mediates the drought-induced expression but not the seed-specific expression of rd22, a gene responsive to dehydration stress in Arabidopsis thaliana","volume":"238","author":"K Yamaguchi-Shinozaki","year":"1993","journal-title":"Molecular and General Genetics MGG"},{"issue":"6","key":"pone.0266254.ref070","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.2135\/cropsci2004.1920","article-title":"Systemic acquired resistance and induced systemic resistance in conventional agriculture","volume":"44","author":"GE Vallad","year":"2004","journal-title":"Crop Science"},{"issue":"6","key":"pone.0266254.ref071","doi-asserted-by":"crossref","first-page":"493","DOI":"10.4161\/psb.4.6.8392","article-title":"Biosynthesis of salicylic acid in plants","volume":"4","author":"Z Chen","year":"2009","journal-title":"Plant signaling & behavior"},{"issue":"1","key":"pone.0266254.ref072","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.molp.2014.12.001","article-title":"A familiar ring to it: biosynthesis of plant benzoic acids","volume":"8","author":"R Widhalm Joshua","year":"2015","journal-title":"Molecular Plant"},{"issue":"3","key":"pone.0266254.ref073","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1094\/MPMI-09-14-0292-FI","article-title":"Hydroxycinnamic acid degradation, a broadly conserved trait, protects Ralstonia solanacearum from chemical plant defenses and contributes to root colonization and virulence","volume":"28","author":"TM Lowe","year":"2015","journal-title":"Molecular Plant-Microbe Interactions"},{"issue":"3","key":"pone.0266254.ref074","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1104\/pp.63.3.536","article-title":"Identification of traumatin, a wound hormone, as 12-oxo-trans-10-dodecenoic acid","volume":"63","author":"DC Zimmerman","year":"1979","journal-title":"Plant Physiology"},{"issue":"4","key":"pone.0266254.ref075","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s12088-007-0054-2","article-title":"Induced systemic resistance (ISR) in plants: mechanism of action","volume":"47","author":"DK Choudhary","year":"2007","journal-title":"Indian J Microbiol"},{"issue":"4","key":"pone.0266254.ref076","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1104\/pp.105.066274","article-title":"Evaluation of the antimicrobial activities of plant oxylipins supports their involvement in defense against pathogens","volume":"139","author":"I Prost","year":"2005","journal-title":"Plant Physiology"},{"issue":"4","key":"pone.0266254.ref077","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/mp\/ssr105","article-title":"Role of 9-lipoxygenase and \u03b1-dioxygenase oxylipin pathways as modulators of local and systemic defense","volume":"5","author":"J Vicente","year":"2012","journal-title":"Molecular Plant"},{"issue":"3","key":"pone.0266254.ref078","first-page":"2324","article-title":"9-Lipoxygenase-derived oxylipins activate brassinosteroid signaling to promote cell wall-based defense and limit pathogen infection","volume":"169","author":"R Marcos","year":"2015","journal-title":"Plant Physiology"},{"key":"pone.0266254.ref079","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fpls.2014.00086","article-title":"Response of plants to water stress","volume":"5","author":"Y Osakabe","year":"2014","journal-title":"Frontiers in Plant Science"},{"issue":"3","key":"pone.0266254.ref080","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1469-8137.2008.02689.x","article-title":"Improving plant stress tolerance and yield production: is the tonoplast aquaporin SlTIP2;2 a key to isohydric to anisohydric conversion?","volume":"181","author":"N Sade","year":"2009","journal-title":"New Phytologist"},{"issue":"3","key":"pone.0266254.ref081","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s11103-005-0352-1","article-title":"Whole gene family expression and drought stress regulation of aquaporins","volume":"59","author":"E Alexandersson","year":"2005","journal-title":"Plant Mol Biol"},{"issue":"11","key":"pone.0266254.ref082","doi-asserted-by":"crossref","first-page":"e79052","DOI":"10.1371\/journal.pone.0079052","article-title":"Genome-wide identification and expression analysis of aquaporins in tomato","volume":"8","author":"S Reuscher","year":"2013","journal-title":"PLOS ONE"},{"issue":"2","key":"pone.0266254.ref083","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/ppl.13324","article-title":"Plant aquaporins alleviate drought tolerance in plants by modulating cellular biochemistry, root-architecture, and photosynthesis","volume":"172","author":"J Patel","year":"2021","journal-title":"Physiologia Plantarum"},{"issue":"4","key":"pone.0266254.ref084","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1104\/pp.103.037614","article-title":"Arabidopsis CYP707As encode (+)-abscisic acid 8\u2019-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid","volume":"134","author":"S Saito","year":"2004","journal-title":"Plant Physiology"},{"issue":"7","key":"pone.0266254.ref085","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1038\/sj.emboj.7600121","article-title":"The Arabidopsis cytochrome P450 CYP707A encodes ABA 8\u2032-hydroxylases: key enzymes in ABA catabolism","volume":"23","author":"T Kushiro","year":"2004","journal-title":"The EMBO Journal"},{"issue":"2","key":"pone.0266254.ref086","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-313X.2006.02683.x","article-title":"CYP707A3, a major ABA 8\u2032-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana","volume":"46","author":"T Umezawa","year":"2006","journal-title":"The Plant Journal"},{"issue":"18","key":"pone.0266254.ref087","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1093\/jxb\/eru288","article-title":"SlNCED1 and SlCYP707A2: key genes involved in ABA metabolism during tomato fruit ripening","volume":"65","author":"K Ji","year":"2014","journal-title":"Journal of Experimental Botany"},{"issue":"5","key":"pone.0266254.ref088","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/BF00016120","article-title":"A tomato cDNA inducible by salt stress and abscisic acid: nucleotide sequence and expression pattern","volume":"15","author":"JA Godoy","year":"1990","journal-title":"Plant Molecular Biology"},{"issue":"7","key":"pone.0266254.ref089","article-title":"Transcriptional responses of Arabidopsis thaliana during wilt disease caused by the soil-borne phytopathogenic bacterium, Ralstonia solanacearum","volume":"3","author":"J Hu","year":"2008","journal-title":"PLOS ONE"},{"issue":"8","key":"pone.0266254.ref090","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1104\/pp.41.8.1387","article-title":"Abnormal stomatal behavior in wilty mutants of tomato","volume":"41","author":"M. Tal","year":"1966","journal-title":"Plant Physiology"},{"issue":"1317","key":"pone.0266254.ref091","article-title":"High stomatal conductance in the tomato flacca mutant allows for faster photosynthetic induction","volume":"11","author":"E Kaiser","year":"2020","journal-title":"Frontiers in Plant Science"},{"issue":"4","key":"pone.0266254.ref092","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1365-3040.2003.01164.x","article-title":"Complementation of notabilis, an abscisic acid-deficient mutant of tomato: importance of sequence context and utility of partial complementation","volume":"27","author":"AJ Thompson","year":"2004","journal-title":"Plant, Cell & Environment"},{"issue":"3","key":"pone.0266254.ref093","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1105\/tpc.106.048058","article-title":"Impairment of cellulose synthases required for Arabidopsis secondary cell wall formation enhances disease resistance","volume":"19","author":"C Hern\u00e1ndez-Blanco","year":"2007","journal-title":"The Plant Cell"},{"issue":"7","key":"pone.0266254.ref094","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1094\/MPMI-10-18-0268-R","article-title":"Deep sequencing reveals early reprogramming of Arabidopsis root transcriptomes upon Ralstonia solanacearum infection","volume":"32","author":"C Zhao","year":"2019","journal-title":"Molecular Plant-Microbe Interactions\u00ae"},{"issue":"1","key":"pone.0266254.ref095","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1146\/annurev-phyto-073009-114436","article-title":"Water relations in the interaction of foliar bacterial pathogens with plants","volume":"49","author":"GA Beattie","year":"2011","journal-title":"Annual Review of Phytopathology"},{"key":"pone.0266254.ref096","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.py.33.090195.001045","article-title":"The secret life of foliar bacterial pathogens on leaves","volume":"33","author":"GA Beattie","year":"1995","journal-title":"Annual Review of Phytopathology"},{"issue":"3","key":"pone.0266254.ref097","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1104\/pp.104.052084","article-title":"The Arabidopsis trehalose-6-P synthase AtTPS1 gene is a regulator of glucose, abscisic acid, and stress signaling","volume":"136","author":"N Avonce","year":"2004","journal-title":"Plant Physiology"},{"issue":"1","key":"pone.0266254.ref098","first-page":"1","article-title":"AtTPS1-mediated trehalose 6-phosphate synthesis is essential for embryogenic and vegetative growth and responsiveness to ABA in germinating seeds and stomatal guard cells","volume":"64","author":"LD Gomez","year":"2010","journal-title":"The Plant Journal"},{"issue":"1","key":"pone.0266254.ref099","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/s12870-019-1986-5","article-title":"Overexpression of the trehalose-6-phosphate phosphatase family gene AtTPPF improves the drought tolerance of Arabidopsis thaliana","volume":"19","author":"Q Lin","year":"2019","journal-title":"BMC Plant Biology"},{"key":"pone.0266254.ref100","article-title":"The Arabidopsis thaliana trehalose-6-phosphate phosphatase gene AtTPPI enhances drought tolerance by regulating stomatal apertures","author":"Q Lin","year":"2020","journal-title":"Journal of Experimental Botany"},{"key":"pone.0266254.ref101","doi-asserted-by":"crossref","DOI":"10.1111\/jipb.12925","article-title":"Trehalose-6-phosphate phosphatase e modulates ABA-controlled root growth and stomatal movement in Arabidopsis","author":"W Wang","year":"2020","journal-title":"Journal of Integrative Plant Biology"},{"issue":"8","key":"pone.0266254.ref102","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.phytochem.2007.02.011","article-title":"Iodus 40, salicylic acid, heptanoyl salicylic acid and trehalose exhibit different efficacies and defence targets during a wheat\/powdery mildew interaction","volume":"68","author":"D Renard-Merlier","year":"2007","journal-title":"Phytochemistry"},{"issue":"3","key":"pone.0266254.ref103","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1046\/j.1469-8137.2001.00035.x","article-title":"Trehalose induces resistance to powdery mildew in wheat","volume":"149","author":"P Reignault","year":"2000","journal-title":"New Phytologist"},{"issue":"3","key":"pone.0266254.ref104","doi-asserted-by":"crossref","DOI":"10.1038\/nplants.2017.23","article-title":"Drought resistance: Spraying for yield","volume":"3","author":"S. Smeekens","year":"2017","journal-title":"Nature Plants"},{"issue":"1","key":"pone.0266254.ref105","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12870-017-1207-z","article-title":"Exogenous trehalose improves growth under limiting nitrogen through upregulation of nitrogen metabolism","volume":"17","author":"Y Lin","year":"2017","journal-title":"BMC Plant Biol"},{"issue":"6","key":"pone.0266254.ref106","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4161\/psb.20066","article-title":"Tomato responds to green peach aphid infestation with the activation of trehalose metabolism and starch accumulation","volume":"7","author":"V Singh","year":"2012","journal-title":"Plant Signal Behav"},{"issue":"6","key":"pone.0266254.ref107","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/mpp.12035","article-title":"Salicylic acid: an old hormone up to new tricks","volume":"14","author":"JL Boatwright","year":"2013","journal-title":"Molecular Plant Pathology"},{"issue":"6","key":"pone.0266254.ref108","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1744-7909.2011.01043.x","article-title":"Salicylic acid and its function in plant immunity","volume":"53","author":"C An","year":"2011","journal-title":"Journal of Integrative Plant Biology"},{"issue":"4","key":"pone.0266254.ref109","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1073\/pnas.032485099","article-title":"Resistance to Ralstonia solanacearum in Arabidopsis thaliana is conferred by the recessive RRS1-R gene, a member of a novel family of resistance genes","volume":"99","author":"L Deslandes","year":"2002","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"pone.0266254.ref110","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1399-3054.2009.01226.x","article-title":"Virus-induced gene silencing reveals the involvement of ethylene-, salicylic acid- and mitogen-activated protein kinase-related defense pathways in the resistance of tomato to bacterial wilt","volume":"136","author":"YY Chen","year":"2009","journal-title":"Physiologia Plantarum"},{"issue":"10","key":"pone.0266254.ref111","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1094\/PHYTO.2002.92.10.1142","article-title":"Delayed symptom development in ein2-1, an Arabidopsis ethylene-insensitive mutant, in response to bacterial wilt caused by Ralstonia solanacearum","volume":"92","author":"J Hirsch","year":"2002","journal-title":"Phytopathology"},{"issue":"1","key":"pone.0266254.ref112","doi-asserted-by":"crossref","first-page":"e15853","DOI":"10.1371\/journal.pone.0015853","article-title":"Ralstonia solanacearum extracellular polysaccharide is a specific elicitor of defense responses in wilt-resistant tomato plants","volume":"6","author":"A Milling","year":"2011","journal-title":"PLOS ONE"},{"issue":"4","key":"pone.0266254.ref113","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0048-4059(74)90032-0","article-title":"Catechol-induced resistance of tomato plants to Fusarium wilt","volume":"4","author":"N Retig","year":"1974","journal-title":"Physiological Plant Pathology"},{"issue":"11","key":"pone.0266254.ref114","doi-asserted-by":"crossref","first-page":"e0166938","DOI":"10.1371\/journal.pone.0166938","article-title":"Salicylic acid is involved in the basal resistance of tomato plants to Citrus Excortis Viroid and Tomato Spotted Wilt Virus","volume":"11","author":"MP L\u00f3pez-Gresa","year":"2016","journal-title":"PLOS ONE"},{"issue":"3","key":"pone.0266254.ref115","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1105\/tpc.009159","article-title":"NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol","volume":"15","author":"SH Spoel","year":"2003","journal-title":"The Plant Cell"},{"issue":"5","key":"pone.0266254.ref116","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1365-3059.2008.01858.x","article-title":"Involvement of jasmonic acid signalling in bacterial wilt disease resistance induced by biocontrol agent Pythium oligandrum in tomato","volume":"57","author":"S Hase","year":"2008","journal-title":"Plant Pathology"},{"issue":"1","key":"pone.0266254.ref117","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12915-017-0443-x","article-title":"Plant hormone transporters: what we know and what we would like to know","volume":"15","author":"J Park","year":"2017","journal-title":"BMC Biol"},{"issue":"1","key":"pone.0266254.ref118","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1360-1385(96)10050-9","article-title":"Hormones from roots as signals for the shoots of stressed plants","volume":"2","author":"M. Jackson","year":"1997","journal-title":"Trends in Plant Science"},{"issue":"3","key":"pone.0266254.ref119","article-title":"Degradation of the plant defense signal salicylic acid protects Ralstonia solanacearum from toxicity and enhances virulence on tobacco","volume":"7","author":"TM Lowe-Power","year":"2016","journal-title":"MBio"},{"issue":"2","key":"pone.0266254.ref120","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/tpj.12027","article-title":"Arabidopsis wat1 (walls are thin1)-mediated resistance to the bacterial vascular pathogen, Ralstonia solanacearum, is accompanied by cross-regulation of salicylic acid and tryptophan metabolism","volume":"73","author":"N Denanc\u00e9","year":"2013","journal-title":"The Plant Journal"},{"issue":"10","key":"pone.0266254.ref121","doi-asserted-by":"crossref","first-page":"e46763","DOI":"10.1371\/journal.pone.0046763","article-title":"Transcriptome analysis of quantitative resistance-specific response upon Ralstonia solanacearum infection in tomato","volume":"7","author":"T Ishihara","year":"2012","journal-title":"PLOS ONE"},{"key":"pone.0266254.ref122","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.plantsci.2013.03.004","article-title":"Signaling cross-talk in plant disease resistance","volume":"207","author":"H Derksen","year":"2013","journal-title":"Plant Science"},{"issue":"1","key":"pone.0266254.ref123","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev.phyto.43.040204.135923","article-title":"Contrasting mechanisms of defense against biotrophic and necrotophic pathogens","volume":"43","author":"J. Glazebrook","year":"2005","journal-title":"Annual Review of Phytopathology"},{"issue":"1","key":"pone.0266254.ref124","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1105\/tpc.19.00487","article-title":"Oxylipins other than jasmonic acid are xylem resident signals regulating systemic resistance induced by Trichoderma virens in maize","volume":"32","author":"K-D Wang","year":"2020","journal-title":"The Plant Cell"},{"issue":"3","key":"pone.0266254.ref125","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1104\/pp.010843","article-title":"Evidence supporting a role of jasmonic acid in Arabidopsis leaf senescence","volume":"128","author":"Y He","year":"2002","journal-title":"Plant Physiology"},{"key":"pone.0266254.ref126","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.micres.2017.08.009","article-title":"Osmoprotective functions conferred to soybean plants via inoculation with Sphingomonas sp. LK11 and exogenous trehalose","volume":"205","author":"S Asaf","year":"2017","journal-title":"Microbiological Research"},{"issue":"9","key":"pone.0266254.ref127","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1128\/AEM.00984-06","article-title":"Two host-induced Ralstonia solanacearum genes, acrA and dinF, encode multidrug efflux pumps and contribute to bacterial wilt virulence","volume":"73","author":"DG Brown","year":"2007","journal-title":"Applied and Environmental Microbiology"},{"issue":"3","key":"pone.0266254.ref128","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/pmpp.2000.0287","article-title":"Phenolic-storing cells: keys to programmed cell death and periderm formation in wilt disease resistance and in general defence responses in plants?","volume":"57","author":"CH Beckman","year":"2000","journal-title":"Physiological and Molecular Plant Pathology"},{"issue":"5","key":"pone.0266254.ref129","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/aob\/mcl034","article-title":"Rapid accumulation of trihydroxy oxylipins and resistance to the bean rust pathogen Uromyces fabae following wounding in Vicia faba","volume":"97","author":"DR Walters","year":"2006","journal-title":"Ann Bot"},{"issue":"2","key":"pone.0266254.ref130","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1046\/j.1365-313X.2003.01718.x","article-title":"Reactive electrophile species activate defense gene expression in Arabidopsis","volume":"34","author":"E Alm\u00e9ras","year":"2003","journal-title":"The Plant Journal"},{"key":"pone.0266254.ref131","doi-asserted-by":"crossref","first-page":"112334","DOI":"10.1016\/j.phytochem.2020.112334","article-title":"Relative contribution of LOX10, green leaf volatiles and JA to wound-induced local and systemic oxylipin and hormone signature in Zea mays (maize)","volume":"174","author":"Y He","year":"2020","journal-title":"Phytochemistry"},{"issue":"6","key":"pone.0266254.ref132","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0981-9428(02)01402-X","article-title":"Lipoxygenase-mediated production of fatty acid hydroperoxides is a specific signature of the hypersensitive reaction in plants","volume":"40","author":"J-L Montillet","year":"2002","journal-title":"Plant Physiology and Biochemistry"},{"issue":"1","key":"pone.0266254.ref133","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev-phyto-082718-100146","article-title":"Damage-Associated Molecular Patterns (DAMPs) in plant innate immunity: applying the danger model and evolutionary perspectives","volume":"59","author":"K Tanaka","year":"2021","journal-title":"Annual Review of Phytopathology"},{"issue":"1","key":"pone.0266254.ref134","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1365-313X.2011.04671.x","article-title":"Interplay between calcium signalling and early signalling elements during defence responses to microbe- or damage-associated molecular patterns","volume":"68","author":"S Ranf","year":"2011","journal-title":"The Plant Journal"},{"key":"pone.0266254.ref135","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3389\/fpls.2019.00646","article-title":"Damage-Associated Molecular Pattern-triggered immunity in plants","volume":"10","author":"S Hou","year":"2019","journal-title":"Frontiers in Plant Science"},{"issue":"11","key":"pone.0266254.ref136","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.it.2018.09.006","article-title":"Extracellular DAMPs in plants and mammals: Immunity, tissue damage and repair","volume":"39","author":"G De Lorenzo","year":"2018","journal-title":"Trends in Immunology"},{"key":"pone.0266254.ref137","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3389\/fpls.2014.00470","article-title":"Wounding in the plant tissue: the defense of a dangerous passage","volume":"5","author":"DV Savatin","year":"2014","journal-title":"Frontiers in Plant Science"},{"issue":"11","key":"pone.0266254.ref138","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1093\/jxb\/ers129","article-title":"Sugars and plant innate immunity","volume":"63","author":"MR Bolouri Moghaddam","year":"2012","journal-title":"Journal of Experimental Botany"},{"issue":"9","key":"pone.0266254.ref139","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1094\/PD-89-0989","article-title":"Application of Acibenzolar-S-Methyl enhances host resistance in tomato against Ralstonia solanacearum","volume":"89","author":"PM Pradhanang","year":"2005","journal-title":"Plant Disease"},{"issue":"1","key":"pone.0266254.ref140","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1023\/A:1008730721037","article-title":"\u03b2-Aminobutyric acid-induced resistance in plants","volume":"107","author":"G Jakab","year":"2001","journal-title":"European Journal of Plant Pathology"},{"issue":"1","key":"pone.0266254.ref141","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10658-012-0149-4","article-title":"Activation of tomato plant defence responses against bacterial wilt caused by Ralstonia solanacearum using DL-3-aminobutyric acid (BABA)","volume":"136","author":"MAE Hassan","year":"2013","journal-title":"European Journal of Plant Pathology"},{"key":"pone.0266254.ref142","doi-asserted-by":"crossref","first-page":"561056","DOI":"10.1155\/2013\/561056","article-title":"Elicitor-induced defense responses in Solanum lycopersicum against Ralstonia solanacearum","volume":"2013","author":"S Mandal","year":"2013","journal-title":"The Scientific World Journal"},{"issue":"9","key":"pone.0266254.ref143","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1093\/pcp\/pcw114","article-title":"L-Histidine induces resistance in plants to the bacterial pathogen Ralstonia solanacearum partially through the activation of ethylene signaling","volume":"57","author":"S Seo","year":"2016","journal-title":"Plant Cell Physiol"},{"key":"pone.0266254.ref144","article-title":"Ralstonia solanacearum depends on catabolism of myo-inositol, sucrose, and trehalose for virulence in an infection stage-dependent manner","author":"CD Hamilton","year":"2021","journal-title":"Molecular Plant-Microbe Interactions"},{"issue":"6","key":"pone.0266254.ref145","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02065-14","article-title":"A Ralstonia solanacearum type III effector directs the production of the plant signal metabolite trehalose-6-phosphate","volume":"5","author":"M Poueymiro","year":"2014","journal-title":"MBio"},{"issue":"5","key":"pone.0266254.ref146","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00895-17","article-title":"A single regulator mediates strategic switching between attachment\/spread and growth\/virulence in the plant pathogen Ralstonia solanacearum","volume":"8","author":"D Khokhani","year":"2017","journal-title":"MBio"},{"key":"pone.0266254.ref147","article-title":"FastQC A Quality Control Tool for High Throughput Sequence Data","author":"S. Andrews","journal-title":"Babraham Bioinformatics"},{"issue":"15","key":"pone.0266254.ref148","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"AM Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"pone.0266254.ref149","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"A Dobin","year":"2012","journal-title":"Bioinformatics"},{"issue":"16","key":"pone.0266254.ref150","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"H Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"2","key":"pone.0266254.ref151","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"S Anders","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"pone.0266254.ref152","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"MD Robinson","year":"2009","journal-title":"Bioinformatics"},{"issue":"12","key":"pone.0266254.ref153","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014","journal-title":"Genome Biology"},{"issue":"1","key":"pone.0266254.ref154","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society Series B (Methodological)"},{"issue":"1","key":"pone.0266254.ref155","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2105-15-91","article-title":"Differential meta-analysis of RNA-seq data from multiple studies","volume":"15","author":"A Rau","year":"2014","journal-title":"BMC Bioinformatics"},{"issue":"8","key":"pone.0266254.ref156","first-page":"2628","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"SX Ge","year":"2019","journal-title":"Bioinformatics"},{"issue":"W1","key":"pone.0266254.ref157","doi-asserted-by":"crossref","first-page":"W122","DOI":"10.1093\/nar\/gkx382","article-title":"AgriGO v2.0: a GO analysis toolkit for the agricultural community, 2017 update","volume":"45","author":"T Tian","year":"2017","journal-title":"Nucleic Acids Research"},{"issue":"D1","key":"pone.0266254.ref158","doi-asserted-by":"crossref","first-page":"D419","DOI":"10.1093\/nar\/gky1038","article-title":"PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools","volume":"47","author":"H Mi","year":"2018","journal-title":"Nucleic Acids Research"},{"issue":"D1","key":"pone.0266254.ref159","doi-asserted-by":"crossref","first-page":"D1178","DOI":"10.1093\/nar\/gkr944","article-title":"Phytozome: a comparative platform for green plant genomics","volume":"40","author":"DM Goodstein","year":"2011","journal-title":"Nucleic Acids Research"},{"key":"pone.0266254.ref160","unstructured":"Kolde R. pheatmap: Pretty Heatmaps 2019 [June 7, 2020]. Available from: https:\/\/cran.r-project.org\/web\/packages\/pheatmap\/index.html."},{"key":"pone.0266254.ref161","unstructured":"R. R: The R Project for Statistical Computing [June 7, 2020]. Available from: https:\/\/www.r-project.org\/."},{"key":"pone.0266254.ref162","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-24277-4","author":"H. Wickham","year":"2016","journal-title":"ggplot2: Elegant graphics for data analysis"},{"issue":"7400","key":"pone.0266254.ref163","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nature11119","article-title":"The tomato genome sequence provides insights into fleshy fruit evolution","volume":"485","author":"S Sato","year":"2012","journal-title":"Nature"},{"issue":"5930","key":"pone.0266254.ref164","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.1172408","article-title":"Regulators of PP2C Phosphatase Activity Function as Abscisic Acid Sensors","volume":"324","author":"Y Ma","year":"2009","journal-title":"Science"},{"issue":"1","key":"pone.0266254.ref165","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1746-4811-7-37","article-title":"Rapid and sensitive hormonal profiling of complex plant samples by liquid chromatography coupled to electrospray ionization tandem mass spectrometry","volume":"7","author":"M M\u00fcller","year":"2011","journal-title":"Plant Methods"},{"issue":"1","key":"pone.0266254.ref166","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1128\/aem.48.1.94-101.1984","article-title":"Lipopolysaccharide defective mutants of the wilt pathogen Pseudomonas solanacearum","volume":"48","author":"CA Hendrick","year":"1984","journal-title":"Applied and Environmental Microbiology"},{"issue":"18","key":"pone.0266254.ref167","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3028","article-title":"Plant assays for quantifying Ralstonia solanacearum virulence","volume":"8","author":"D Khokhani","year":"2018","journal-title":"Bio-Protocol"},{"key":"pone.0266254.ref168","first-page":"521","article-title":"The Never Ripe mutation blocks ethylene perception in tomato","volume":"6","author":"MB Lanahan","year":"1994","journal-title":"The Plant Cell"},{"issue":"3","key":"pone.0266254.ref169","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1365-313x.2000.00778.x","article-title":"Salicylic acid is not required for Cf-2- and Cf-9-dependent resistance of tomato to Cladosporium fulvum","volume":"23","author":"PA Brading","year":"2000","journal-title":"The Plant Journal"},{"issue":"3","key":"pone.0266254.ref170","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1071\/BI9620413","article-title":"A re-examination of the relative turgidity technique for estimating water deficits in leaves","volume":"15","author":"HD Barrs","year":"1962","journal-title":"Australian Journal of Biological Sciences"},{"issue":"2","key":"pone.0266254.ref171","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11120-010-9606-0","article-title":"Use of a SPAD-502 meter to measure leaf chlorophyll concentration in Arabidopsis thaliana","volume":"107","author":"Q Ling","year":"2011","journal-title":"Photosynth Res"},{"issue":"10","key":"pone.0266254.ref172","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1128\/AEM.00345-14","article-title":"Xanthomonas perforans colonization influences Salmonella enterica in the tomato phyllosphere","volume":"80","author":"N Potnis","year":"2014","journal-title":"Applied and environmental microbiology"},{"issue":"7","key":"pone.0266254.ref173","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1094\/MPMI-22-7-0773","article-title":"Ralstonia solanacearum encounters an oxidative environment during tomato infection","volume":"22","author":"Z Flores-Cruz","year":"2009","journal-title":"Molecular Plant-Microbe Interactions"},{"issue":"6","key":"pone.0266254.ref174","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1046\/j.1365-313X.1997.11061187.x","article-title":"Subcellular localization of H2O2 in plants. H2O2 accumulation in papillae and hypersensitive response during the barley\u2014powdery mildew interaction","volume":"11","author":"H Thordal-Christensen","year":"1997","journal-title":"The Plant Journal"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0266254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T17:28:41Z","timestamp":1651080521000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0266254"}},"subtitle":[],"editor":[{"given":"Ching-Hong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":174,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0266254","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]}}}