{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T20:53:50Z","timestamp":1754600030782,"version":"3.40.5"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>This is a registered study protocol on a randomized controlled trial (RCT) testing an intervention aimed to improve men\u2019s adherence to evidence-based guidelines on BRCA1\/2 germline genetic testing. <jats:italic>BRCA1<\/jats:italic>- and <jats:italic>BRCA2-<\/jats:italic>associated Hereditary Breast and Ovarian Cancer Syndrome (HBOC) increases the relative and absolute risk of developing breast and ovarian cancer and, to a lesser extent, prostate and pancreatic cancer. Men face <jats:italic>BRCA<\/jats:italic>-related cancer risks as women do, although with a different magnitude, and they may also transmit the mutations to their children. Notwithstanding, men are under-tested compared to women and the communication is not tailored on their needs. The present RCT applies principles of the Health Action Process Approach (HAPA) in testing the psychological determinants of the men\u2019s adherence to evidence based guidelines on BRCA1\/2 germline genetic and testing the efficacy of two messages.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A total of 264 participants will be involved, among the men\u2019s relatives of women with verified germline mutations. The study entails a pre- post- evaluation with randomization of the participants in two conditions corresponding to the two messages.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Discussion<\/jats:title>\n<jats:p>The expected results provide answers related to the impact of action self-efficacy, outcome expectancy (personal or familiar), risk perception, health risk aversion, intolerance of uncertainty, perceived barriers, and coping self-efficacy on informed decision-making. Data gathered from this study may inform health care providers, policy makers, and public health managers about the communication strategy for men and about the psychological variables influencing decision-making.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Trail registration<\/jats:title>\n<jats:p><jats:bold>Name of the Registry:<\/jats:bold> Clinical Trials. <jats:bold>Trial registration number:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04683068\" xlink:type=\"simple\">NCT04683068<\/jats:ext-link>. <jats:bold>Date of registration:<\/jats:bold> 16\/12\/2020. <jats:bold>URL of trial registry record:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/\" xlink:type=\"simple\">https:\/\/www.clinicaltrials.gov\/<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0266327","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T17:31:40Z","timestamp":1649439100000},"page":"e0266327","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["A randomized controlled trial comparing self-referred message to family-referred message promoting men\u2019s adherence to evidence-based guidelines on BRCA1\/2 germline genetic testing: A registered study 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